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Found 80 clinical trials
Featured trial
Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Skeletal Muscle Function in Heart Failure Subjects

exercises. Cardiopulmonary exercise testing. Participants may ride a stationary bike or walk on a treadmill. A facemask will analyze their breath. Heart and blood pressure measurements will be taken

chronic heart failure
cardiopulmonary exercise testing
heart failure
radionuclide ventriculography
systolic heart failure
  • 09 Apr, 2019
  • 1 location
  • 09 Apr, 2023
  • 12 locations
Molecular Transducers of Physical Activity Consortium (MoTrPAC)

The goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to assess molecular changes that occur in response to physical activity (PA). To achieve this aim, a mechanistic randomized controlled trial (RCT) is conducted, in which adult study participants are randomized to endurance exercise (EE) training, resistance exercise …

Accepts healthy volunteers
  • 17 Feb, 2022
  • 9 locations
Remote Exercise Testing in Patients With Pulmonary Hypertension

The investigators plan to investigate the feasibility and validity of tests of exercise capacity, when these are performed in hospital and at home, by patients who are diagnosed with pulmonary hypertension. Patients with pulmonary hypertension develop high blood pressure within the lungs, leading to a limitation in the amount of …

exercise stress test
walk tests
  • 23 Apr, 2022
  • 1 location
Rehabilitation for Patients With Persistent Symptoms Post COVID-19

wil be used: Cardiopulmonary exercise testing, lung function, functional performance tests, questionnaires regarding dyspnea, fatigue, anxiety, depression, work-status, health status, sleep behavior

  • 18 Apr, 2021
  • 1 location
Mechanisms of Exercise Intolerance in Heart Failure With Preserved Ejection Fraction

The global objective of this study is to determine the mechanisms of exercise intolerance and dyspnea on exertion (DOE) in patients with HFpEF and based on this pathophysiology, test whether specific exercise training programs (whole body vs single leg) will result in improved exercise tolerance.

heart failure with preserved ejection fraction
ejection fraction
diastolic dysfunction
  • 27 May, 2022
  • 1 location
Mechanistic Clinical Trial of Advanced Imaging for CRT

This is a mechanistic clinical trial with randomization to guidance for the CRT procedure using cardiac magnetic resonance (CMR) and computed tomography angiography (CTA) versus a standard procedure.

  • 26 Feb, 2022
  • 1 location
NAD+ Precursor Supplementation With Exercise Training to Increase Aerobic Capacity in Friedreich's Ataxia (ExRx in FA)

Randomized, placebo-controlled trial with a 2x2 factorial design testing the effects of an NAD+ precursor (NR) and exercise on VO2max and Si in Friedreich's Ataxia (FA). The primary objective of this research is to measure the effect of combination administration (NR + exercise) on aerobic capacity (VO2max) in FA. A …

  • 14 Oct, 2022
  • 1 location
Splanchnic Nerve Block for Therapy of Chronic Heart Failure (Splanchnic III)

Splanchnic vasoconstriction may contribute to decompensation of chronic heart failure (HF) via volume redistribution from the splanchnic vascular bed to the central compartment. This is a sympathetically mediated reflex and can be interrupted through a splanchnic nerve block (SNB). We hypothesize that interruption of the efferent/afferent innervation of the splanchnic …

  • 30 Nov, 2021
  • 1 location
A Monocentric Randomised Controlled Trial to Investigate Changes in the Circulating Sphingolipidome Composition of Young and Healthy Individuals in Response to a Single Session of High-intensity Interval Training: the SphingoHIIT Study (SphingoHIIT)

The purpose of this study is to examine the response of a comprehensive panel of circulating sphingolipids to a single high-intensity interval training (HIIT) session in healthy individuals in their twenties.

Accepts healthy volunteers
  • 15 Oct, 2022
  • 1 location