Found 14 clinical trials
Immunological Mechanisms Underlying Neuroprotection from Exercise in Alzheimer’s disease
This study is looking for healthy people over the age of 60. There is no treatment or experiment being tested. The study is interested in the relationship between genetics, physical activity, and the risk of developing Alzheimer’s.
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- 25 Feb, 2022
- 1 location
Exercise Testing in Diseases and Health
Cardiopulmonary exercise test (CPET) is a helpful tool for evaluation of aerobic exercise capacity and tolerance for variety of population. CPET provides a full assessment of the physiologic responses of the pulmonary, cardiovascular, muscular, and cellular oxidative systems to exercise. The test progression include a incremental stepwise (on treadmill) or …
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- 13 Apr, 2022
- 1 location
Multi-level Molecular Profiling of Peak Performance in Endurance Sports (MSSA)
Physical activity triggers complex molecular responses, including changes in immune-, stress-, and metabolic pathways. For example, autophagy is essential for energy and cellular homeostasis through protein catabolism, and dysregulation results in compromised proteostasis, reduced exercise performance, and excessive secretion of signaling molecules and inflammatory proteins. However, previous research has been …
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- 16 May, 2022
- 1 location
Development of Novel Physiological CMR Methods in Health and Disease
of them offer varied insight into cardiac physiological adaptation: passive leg raise, intra-venous fluid challenge, pharmacological stressors and physical exercise stress test. Echocardiography
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- 02 Mar, 2022
- 1 location
Cost-effectiveness of Forced Aerobic Exercise for Stroke Rehabilitation
The purpose of this study is to investigate whether aerobic exercise improves the participant's ability to recover function in the arm and leg affected by the participant's stroke. The investigators are also calculating the cost effectiveness of the rehabilitation interventions.
- 7 views
- 09 Feb, 2022
- 1 location
PRIZE ET Sub-Study
Microvascular angina (MVA) is caused by abnormalities of the small blood vessels in the heart. Endothelin-1 (ET-1) is a chemical messenger that circulates and accumulates in the blood vessel walls, causing them to narrow or go into spasm and thicken over a long period, especially as levels of ET-1 increase. …
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- 01 Oct, 2021
- 1 location
Rehabilitation by Eccentric Exercise in Heart Failure Patients (REX-HF)
As part of the regular rehabilitation program for chronic heart failure (CHF) patients, the addition of dynamic eccentric endurance (ECC) exercise sessions to the conventional concentric cycling program (CON) would enable greater gains in functional capacity that the CON alone. Furthermore, in the case of severe heart failure, results of …
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- 07 Feb, 2022
- 1 location
Effectiveness of TechCR Among CHD Patients
During this ongoing pandemic, there is a crucial need for innovative approaches to deliver CR programmes other than frequent face-to-face sessions at the centre-based CR to reduce the number of times people come close in contact with others or gathering in large groups. This is a single setting, 2-arm parallel …
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- 09 May, 2021
- 1 location
The Effects of Oral Inorganic Nitrate Supplementation on Lower Limb Perfusion During Exercise in Patients With PAD
Peripheral arterial disease (PAD) is a highly prevalent and costly condition. Intermittent claudication (IC), defined as ischemic leg pain that occurs with walking, results in functional impairment, reduced daily physical activity, and a lower quality of life. Although the mechanisms contributing to functional impairment are not fully delineated, current evidence …
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- 26 Sep, 2021
- 1 location
Diastolic Exercise Stress Testing in Heart Failure
Patients with an intermediate risk (HFA-PEFF score 2-4 points) for heart failure with preserved ejection fraction (HFpEF) will be further investigated with invasive right heart catheterization. All patients with a resting pulmonary artery wedge pressure (PAWP) <15mmHg will undergo the following stress test modalities in a randomized order: (1) bicycle …
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- 21 Sep, 2021
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