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Found 13 clinical trials
Effect of N-803 on B Cell Follicles in Antiretroviral Treated HIV Disease

N-803 has demonstrated ability to reactivate HIV from latency and can activate T cells and NK cells to clear those cells, thus reducing the reservoir. However, a concern is that CD8 T cells may be excluded from the B cell follicles, where a significant part of the reservoir resides. Webb, …

  • 01 May, 2021
  • 2 locations
Pre-operative Magnetic Resonance Imaging (MRI) in Young Breast Cancer Patients

Young women with breast cancer have an increased breast tissue density and conventional imaging tests such as mammography and breast ultrasound are less sensitive and specific for detecting breast cancer than in older breast cancer patients. Breast MRI is an emerging tool that has been proven to improve the ability …

endocrine therapy
hormone therapy
magnetic resonance imaging of breast
invasive breast cancer
  • 07 Nov, 2020
  • 2 locations
Rituximab and Pegfilgrastim in Treating Patients With Non-Hodgkin's Lymphoma

RATIONALE: Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Pegfilgrastim may stimulate the immune system in different ways and stop cancer …

monoclonal antibodies
  • 07 Nov, 2020
  • 1 location
Fluorescence Surgery for Sentinel Node Identification in Melanoma

Sentinel node biopsy is a surgical procedure used to find melanoma lymph node metastasis (i.e. groin/axilla) in very early stages. This study aims to add a new technology over the standard procedure - a fluorescent contrast (indocyanine green) using special light (near infra-red) - looking for more precise diagnosis of …

sentinel node
infrared imaging
  • 21 Jan, 2021
  • 1 location
The Incidence of Adjacent Synchronous Ipsilateral Infiltrating Carcinoma and/or DCIS in Patients Diagnosed With Intraductal Papilloma Without Atypia or Flat Epithelial Atypia by Core Needle Biopsy

This research study is studying a surgical intervention to rule out the presence of cancer in participants that have been diagnosed with flat epithelial atypia (FEA) or intraductal papilloma without atypia (IPWA) by core needle biopsy.

  • 26 Jul, 2021
  • 20 locations
Pre-Treatment of Highly Suspicious Pigmented Skin Lesions With Interleukin-2

This study is meant to assess the use of intralesional IL-2 to modulate the immunological response to suspected melanoma, or melanoma in situ, in an effort to increase lymphocyte infiltration and decrease disease metastasis. Patients that are clinically diagnosed with suspected Melanoma or Melanoma in situ will be assigned to …

  • 28 Jan, 2021
  • 1 location
Delayed Sentinel Lymph Node Biopsy in Ductal Cancer in Situ

The trial aims to investigate the use of superparamagnetic iron oxide (SPIO) nanoparticles as a tracer for delayed sentinel lymph node dissection (d-SLND) in patients where upfront axillary surgery (SLND) is oncologically deemed unnecessary and should be avoided. This includes but is not limited to patients with a preoperative diagnosis …

  • 28 Jan, 2021
  • 8 locations
Investigate the Diagnostic Value and Possibilities of OCT in Non-Melanoma Skin Cancer.

We will do systematic and functional assessment of non-melanoma skin cancer including precancerous lesions by OCT imaging and other diagnostic methods. The systematic assessment will be comparison of clinical diagnosis, histopathology, OCT images, spectrophotometry and high frequency ultrasound of non-melanoma skin cancer Functional exploration of non-melanoma skin cancer is done …

melanoma skin
skin carcinoma
  • 07 Nov, 2020
  • 1 location
Specimen Collections From Patients With HIV Infection KSHV Infection Viral-Related Pre-malignant Lesions and Cancer

obtained by fine needle aspirate, by removal of pleural or peritoneal fluid, by skin punch biopsy, or by excisional biopsy, providing the tumor is accessible with minimal risk to the patients. Specific

HIV Vaccine
skin lesions
kaposi's sarcoma
  • 24 Sep, 2021
  • 1 location
The PREDICT Registry for DCIS Patients With DCISionRT Testing

This is a prospective cohort study for patients diagnosed with ductal carcinoma in situ (DCIS) of the breast. The primary objective of the study is to create a de-identified database of patients, test results, treatment decisions and outcomes that can be queried to determine the utility of the DCISionRT test …

lobular carcinoma in situ
carcinoma in situ
lobular carcinoma
breast disease
  • 15 Apr, 2021
  • 64 locations