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Found 4 clinical trials
The TAPS Trial - Fetoscopic Laser Surgery for Twin Anemia Polycythemia Sequence

This multicenter open-label randomized controlled trial is set up to evaluate the effect of fetoscopic laser surgery on the gestational age at birth for monochorionic twin pregnancies diagnosed with twin anemia-polycythemia sequence. Half op the patients will be treated with fetoscopic laser surgery, while the other half will be managed …

  • 0 views
  • 25 Jan, 2021
  • 4 locations
Sickle Cell Disease and CardiovAscular Risk - Red Cell Exchange Trial (SCD-CARRE) (SCD-CARRE)

The SCD-CARRE trial is a Phase 3, prospective, randomized, multicenter, controlled, parallel two-arm study aimed to determine if automated exchange blood transfusion and standard of care

exchange transfusion
anti-thymocyte globulin
blood transfusion
hydroxyurea
thalassemia
  • 24 views
  • 26 May, 2022
  • 17 locations
Hematopoietic Stem Cell Transplant for Sickle Cell Disease

This is a phase I/II study of patients with sickle cell disease. It aims to find out if people with sickle cell disease can be cured by changing their immune system before they have blood stem cell transplants. Doctors will give patients a new drug (fludarabine) to see if this …

hemoglobin c disease
anti-thymocyte globulin
sickle cell trait
bone marrow transplant
hemoglobin s
  • 84 views
  • 14 Jun, 2022
  • 1 location
Cerebrovascular Reserve and White Matter Disease in Patients With Chronic Anemia (CVR)

This is primarily an observational trial in patients with chronic anemia syndromes (sickle cell disease and thalassemia) and control subjects. The key purpose is to understand how brain blood flow reserve (the ability of the brain to increase its flow in response to stress) is altered in patients with chronic …

anemia
blood transfusion
thalassemia
hydroxyurea
transfusion dependent thalassemia
  • 18 views
  • 15 Feb, 2022
  • 1 location