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Found 324 clinical trials
Safety and Efficacy Study of Sotatercept in Adults With Transfusion Dependent Diamond Blackfan Anemia

The purpose of this study is to determine the safety and dosing of drug Sotatercept, as a subcutaneous injection, to stimulate production of red blood cell production. To be given every 28 days for up to four doses.

  • 31 views
  • 14 Mar, 2021
  • 1 location
Human Cerebral Blood Flow Regulation

This study tests basic differences in how men and women control brain (cerebral) blood flow (CBF), at rest and under stress. The stress is low oxygen or high carbon dioxide. The investigators hypothesize that sex differences per se, plus sex hormone differences, drive different signals in blood vessels that change …

  • 0 views
  • 22 May, 2021
  • 1 location
Novel Combination Therapy for Osteoporosis in Men

Osteoporotic fractures are a key health problem in older men. Although there are drugs approved to treat osteoporosis in men [bisphosphonates, denosumab, and teriparatide (TPTD) or PTH(1-34)], there is a lack of knowledge on how to use them effectively. TPTD is a potent bone anabolic drug, meaning that it builds …

  • 2 views
  • 27 Jan, 2021
  • 1 location
Efficacy and Tolerability of Toremifene or Tamoxifen Therapy in Premenopausal Estrogen and Progesterone Receptor Positive Breast Cancer Patients

tamoxifen, but with a superior risk-benefit profile. In this trial, we sought to compare the efficacy and tolerability of toremifene and tamoxifen therapy in premenopausal patients with operable,estrogen

  • 1 views
  • 08 Nov, 2020
The MASTER Study (MAmmary Cancer STatin ER Positive Study)

Given the compelling evidence supporting a protective effect of statins on breast cancer recurrence, calls for prospective clinical trials have been expressed. In this trial - the MASTER trial - we hypothesize that the addition of statin treatment to the current breast cancer treatment will improve the prognosis of women …

  • 0 views
  • 28 Jan, 2021
  • 1 location
Phase 1 / 2 Study of Amcenestrant (SAR439859) Single Agent and in Combination With Other Anti-cancer Therapies in Postmenopausal Women With Estrogen Receptor Positive Advanced Breast Cancer

Primary Objectives: Dose Escalation: To assess the incidence rate of dose-limiting toxicity (DLT) and to determine the maximum tolerated dose (MTD) as well as the recommended dose (RD) of amcenestrant administered as monotherapy and in combination with palbociclib To assess the incidence rate of DLT and determine the RD of …

ESR1
endocrine therapy
metastasis
primary tumor
erbb2
  • 904 views
  • 01 Aug, 2021
  • 42 locations
A Study of ZN-c5 in Subjects With Breast Cancer

subjects with advanced estrogen receptor positive, human epidermal growth factor receptor 2 negative (ER+/HER2-) breast cancer. ZN-c5 will be evaluated both as monotherapy and in combination with

endocrine therapy
metastasis
erbb2
estrogen
hormone therapy
  • 47 views
  • 25 Jul, 2021
  • 52 locations
A Study of LY3484356 in Women With Breast Cancer Before Having Surgery

The purpose for this study is to see if the study drug, LY3484356, is safe and to determine what effects it has on breast cancer in participants with Estrogen Receptor Positive (ER+), HER2

estrogen
breast carcinoma
erbb2
HER2
carcinoma
  • 0 views
  • 24 Jul, 2021
  • 24 locations
Study of Pembrolizumab (MK-3475) Versus Placebo in Combination With Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage Estrogen Receptor-Positive Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer (MK-3475-756/KEYNOTE-756)

) endocrine therapy in the treatment of adults who have high-risk early-stage estrogen receptor-positive, human epidermal growth factor receptor 2-negative (ER+/HER2-) breast cancer. The primary study

cyclophosphamide
estrogen
progesterone
doxorubicin
growth factor
  • 188 views
  • 05 Aug, 2021
  • 287 locations
Prognostic Evaluation of Changing Endocrine Therapy in Women With Breast Cancer

It suggests in the Guideline that the postmenopausal women with breast cancer who have taken selective estrogen receptor modulators (SERMs) therapy for 2-3 years could benefit from changing

metastasis
estrogen
tamoxifen
x-rays
estrogen receptor
  • 0 views
  • 21 Jan, 2021