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Found 325 clinical trials
Study Evaluating Abemaciclib + Aromatase Inhibitors in HR+ HER2- Advanced Breast Cancer Patients (HERMIONE-7)

The HERMIONE-7 trial is a phase II, single-arm, open-label, multicenter study in HR+, HER2- advanced breast cancer patients who have received HD-FUL as first-line endocrine treatment for their metastatic disease. Patients will receive aromatase inhibitors plus Abemaciclib.

measurable disease
cish
progesterone
HER2
abemaciclib
  • 0 views
  • 19 Jul, 2021
  • 49 locations
Menopausal Sleep Fragmentation and Body Fat Gain

This study aims to investigate the impact of menopause-related sleep fragmentation on metabolic biomarkers of body fat gain. The investigators hypothesize that experimental sleep fragmentation will result in an adverse leptin response as a metabolic biomarker for body fat gain.

gonadotropin
hot flashes
estradiol
mammogram
  • 41 views
  • 27 Jan, 2021
  • 1 location
Effect of Progesterone on Testosterone Concentrations and Breast Development in Transwomen

Purpose. The purpose of this research is study the effect of progesterone therapy on testosterone levels in transwomen who are currently on gender affirming treatment with estradiol. Duration. It is expected that participation will last for 6 months (24 weeks). Study Procedures. Participants will be asked to sign an informed …

  • 0 views
  • 03 Feb, 2021
  • 1 location
Intramuscular Injection of Human Chorionic Gonadotropin in Frozen Embryo Transfer Cycles

This study is a randomized controlled clinical trial to compare the pregnancy outcomes of infertile women with frozen embryo transfer. The study population in frozen embryo transfer cycles receive three doses of human chorionic gonadotropin (HCG) to recognize the effectiveness of HCG on pregnancy outcomes in Reproductive Biomedicine Research Center, …

  • 0 views
  • 03 May, 2021
  • 1 location
Duct Endoscopy in Assessing Cellular Atypia in the Breast Duct Fluid of Women With a Genetic Risk for Breast Cancer

RATIONALE: Diagnostic procedures, such as breast duct endoscopy, may improve the ability to detect breast cancer earlier and plan more effective treatment. PURPOSE: This phase II trial is studying how well breast duct endoscopy works in assessing cellular atypia (abnormal cells) in the breast ducts of women with a genetic …

immunohistochemistry
  • 0 views
  • 07 Nov, 2020
  • 1 location
Nipple Aspiration Ductal Lavage and Duct Endoscopy For Diagnostic Assessment in Women Undergoing Surgery for Breast Cancer

RATIONALE: Diagnostic procedures, such as nipple aspiration, ductal lavage, and breast duct endoscopy, may help doctors detect and assess breast cancer cells early and plan more effective treatment. PURPOSE: This phase II trial is studying how well nipple aspiration, ductal lavage, and duct endoscopy work in assessing cancer cells in …

immunohistochemistry
  • 0 views
  • 07 Nov, 2020
  • 1 location
Estradiol and Progesterone in Hospitalized COVID-19 Patients

The purpose of this study is to determine to what extent a short systemic steroid therapy with estradiol and progesterone, administered early to hospitalized and confirmed COVID-19 positive patients of both sexes in addition to standard of care (SOC) can reduce the severity of symptoms and outcomes compared to SOC …

  • 0 views
  • 29 Jul, 2021
  • 1 location
STARS Breast Trial (Study of Anastrozole and Radiotherapy Sequencing Pilot)

This is a randomized study comparing the use of Anastrozole before and continuing during radiotherapy for breast cancer compared to the use of anastrozole after irradiation.

mastectomy
progesterone receptor
estrogen
progesterone
lumpectomy
  • 51 views
  • 07 Nov, 2020
  • 3 locations
Continuous Versus Cyclic Use of Oral Contraceptive Pills in Adolescents

The primary purpose of this study is to compare the compliance rates of adolescents who take oral contraceptives (OCPs) continuously to those who take OCPs cyclically.

estradiol
  • 215 views
  • 07 Nov, 2020
  • 1 location
Evaluation of Clinical Impact of Interruption VS Maintenance of AI in Patients With Locally Advanced/ Metastatic Low Grade Endometrial Stromal Sarcoma (LGESS)

The primary objective is to compare the progression-free survival (PFS) between aromatase inhibitors interruption and aromatase inhibitors maintenance strategies in patients with a locally advanced or metastatic Low Grade Endometrial Stromal Sarcoma (LGESS).

  • 0 views
  • 24 Jan, 2021
  • 12 locations