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Found 30 clinical trials
A Randomized, Active-controlled, Double-blind, Parallel, Multi Center, Phase 3 Study to Evaluate the Efficacy and Safety of Co-administrated ATB-1011 and ATB-1012 in Patients With Essential Hypertension and Type II Diabetes Mellitus

The purpose of this study is to evaluate safety and efficacy of ATB-1011 and ATB-1012 co-administration in patients with essential hypertension and type II diabetes mellitus

  • 0 views
  • 23 Oct, 2022
  • 1 location
A Cardiosleep Research Program on Obstructive Sleep Apnea Blood Pressure Control and Maladaptive Myocardial Remodeling

The objective of this proposal is to evaluate whether mandibular advancement device (MAD) is non-inferior to continuous positive airway pressure (CPAP) in the treatment of obstructive sleep apnea (OSA) and blood pressure reduction. OSA and hypertension are highly prevalent disorders with profound impacts on health. Apart from improving quality of-life, …

chronic kidney disease
hypertension
oral appliances
mandibular advancement
continuous positive airway pressure
  • 1 views
  • 21 Feb, 2021
  • 1 location
Angiotensin II in General Anesthesia

in patients with underlying essential hypertension and worse in patients taking Angiotensin Converting Enzyme Inhibitors (ACE) and Angiotensin Receptor Blockers (ARBs). Intravenous (IV

angiotensin ii receptor antagonist
hypertension
systolic blood pressure
angiotensin converting enzyme
essential hypertension
  • 0 views
  • 13 Jun, 2022
  • 1 location
MR Antagonist and LSD1

findings of these investigations may lead to a new approach in treating a subset (~30%) of the essential hypertension population (Black LSD1 risk allele hypertensives).

hypertension
essential hypertension
eplerenone
antihypertensive drugs
raised blood pressure
  • 0 views
  • 04 Oct, 2022
  • 1 location
Blood Pressure Reduction in Patients With Asymptomatic Aortic VALVE Stenosis

The aim of this study is to investigate the effect of strict blood pressure control versus conventional care in patients with asymptomatic moderate to severe aortic valve stenosis. The study is a randomized (1:1), open label, controlled intervention trial. Hypothesis Strict BP control for 12 months reduces the progression of …

aortic valve stenosis
aortic valve replacement
stenosis
antihypertensive drugs
  • 0 views
  • 26 Jan, 2021
  • 6 locations
Application of 68Ga-Pentixafor PET/CT in Primary Aldosteronism and Pre-postoperative of SAAE

Primary aldosteronism is the most common cause of secondary hypertension. The two main types of primary aldosteronism are aldosteronoma(30%) and adrenal hyperplasia(60%). The gold standard that determines the diagnosis and treatment strategy of primary aldosteronism is adrenal vein sampling(AVS), but the success rate is only about 80%. Using CXCR4 as …

  • 0 views
  • 04 Oct, 2022
  • 1 location
Neural Mechanism of Aldosterone-induced Insulin Resistance

Patients with high aldosterone hormone have higher blood glucose than normal people. This study is being done to understand how aldosterone hormone affects the nerve activity that controls blood flow in the muscles and blood glucose. The information may be helpful in selecting blood pressure medications which can improve not …

aldosterone
insulin resistance
hypertension
essential hypertension
insulin
  • 70 views
  • 06 Apr, 2022
  • 1 location
Sympathetic Mapping/ Ablation of Renal Nerves Trial - Hemodialysis

To evaluate the safety and efficacy of targeted renal sympathetic denervation using SyMapCath I in patients on hemodialysis with pharmacotherapy and uncontrolled hypertension for at least 6 months, then after standardized antihypertensive drug therapy (at least two drugs) for at least 28 days, office systolic blood pressure (BP) is still …

  • 0 views
  • 11 May, 2021
  • 1 location
The Comparison Between Spironolactone and Indapamide Monotherapy or in Combination With Amlodipine to Reduce the Risk of Heart Failure

Study name: The comparison between spironolactone and indapamide monotherapy or in combination with amlodipine to reduce thr risk of heart failure (SIRRHF) Medicine: spironolactone (20mg/tablet), indapamide (1.5mg/tablet) and amlodipine (5mg/tablet). Rationale: Our hypothesis of the present trial is that spironolactone is superior to indapamide in cardiovascular prevention in hypertensive patients, …

hypertension
essential hypertension
antihypertensive drugs
amlodipine
  • 17 views
  • 16 Dec, 2021
  • 3 locations
Calcium Channel Blockade in Primary Aldosteronism

Primary aldosteronism is a common cause of hypertension. Recent evidence suggests that many patients with bilateral idiopathic hyperaldosteronism harbor gain-of-function somatic mutations in zona glomerulosa calcium channels that results in aldosterone production. This finding raises the possibility that calcium channel antagonists may be a targeted therapy to reduce aldosterone production …

aldosterone
renin
hypertension
calcium channel
hyperaldosteronism
  • 0 views
  • 16 Dec, 2021
  • 1 location