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Found 370 clinical trials
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099280 in Participants With Advanced Solid Tumors

The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics, pharmacodynamics, and early clinical activity of INCB099280 in participants with select solid tumors

solid tumors
solid tumour
  • 20 views
  • 19 Jun, 2022
  • 16 locations
Study BT8009-100 in Subjects With Nectin-4 Expressing Advanced Solid Tumors Malignancies

This clinical trial is evaluating a drug called BT8009 alone and in combination with nivolumab in participants with advanced solid tumors associated with Nectin-4 expression or in participants with advanced solid tumor malignancies having renal insufficiency. The main goals of this study are to: Find the recommended dose of BT8009 …

EGFR
triple negative breast cancer
targeted therapy
carcinoma
line of therapy
  • 109 views
  • 22 Mar, 2022
  • 16 locations
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic …

other malignancy
cancer chemotherapy
human immunodeficiency virus
vismodegib
pi3k-beta inhibitor gsk2636771
  • 6575 views
  • 27 Jun, 2022
  • 913 locations
First-in-human Study of DS-1062a for Advanced Solid Tumors (TROPION-PanTumor01)

This study is one single group of participants with non-small cell lung cancer (NSCLC) who have not been cured by other treatments. It is the first time the drug has been used in humans, and will be in two parts. The primary purpose of the parts are: Dose Escalation: To …

epidermal growth factor
solid tumor
cancer chemotherapy
targeted therapy
triple negative breast cancer
  • 280 views
  • 21 Mar, 2022
  • 14 locations
Aspirin Use for Gastric Cancer Prevention in the Early Gastric Cancer Patients

This study aimed to investigate the effect of low-dose (100 mg) asprin on the prevention of gastric cancer in the early gastric cancer patients with negative H. pylori status who underwent endoscopic submucosal dissection.

early gastric cancer
endoscopic submucosal dissection
  • 0 views
  • 23 May, 2021
  • 13 locations
Proton Therapy for Esophageal Cancer

advanced esophageal cancer and is also a potent radiosensitizer. Second, the substitution of carboplatin for cisplatin has resulted in reduced toxicity of various combination regimens similar to that used

endoscopic ultrasound
celiac disease
paclitaxel
endoscopy
carboplatin
  • 77 views
  • 11 Mar, 2022
  • 1 location
Prehabilitation in Esophageal Cancer Care

of multimodal prehabilitation in esophageal cancer care.

metastatic esophageal cancer
esophagus cancer
immunomodulator
  • 0 views
  • 04 Oct, 2021
  • 1 location
Chemoradiotherapy for Advanced Esophageal Cancer (PaRCUS)

quality of life in patients with unresectable esophageal cancer.

paclitaxel
kidney function test
carboplatin
dysphagia
carcinoma
  • 0 views
  • 22 Apr, 2022
  • 1 location
Thromboprophylaxis in Oesophageal Cancer Patients

The purpose of the study is to examine the efficacy and safety of prolonged thromboprophylactic treatment with Fragmin in oesophageal cancer patients undergoing intended curative surgery.

cancer
esophagus cancer
  • 0 views
  • 10 Oct, 2021
  • 1 location
Chemoradiotherapy in Unresectable Esophageal Cancer

This phase I/II clinical study is designed to evaluate the 1 year local tumor control rate of chemoradiotherapy using albumin-bound paclitaxel and cisplatin in unresectable esophageal squamous cell carcinomas based on Nutritional Risk Screening NRS2002.

celiac disease
paclitaxel
carcinoma
cancer
esophagus cancer
  • 0 views
  • 27 Feb, 2022
  • 1 location