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Found 362 clinical trials
Nutrition in Gastrointestinal Tumors

Malnutrition and loss of muscle mass frequently occur in patients undergoing chemotherapy and can negatively effect therapy outcome. Especially patients with cancer of the gastrointestinal tract are often affected by malnutrition. Therefore, this study aims to examine changes in nutritional status of patients with cancer of the gastrointestinal tract during …

gastrointestinal cancer
cytostatic drugs
cancer chemotherapy
cytostatic
gastrointestinal tumor
  • 0 views
  • 09 Nov, 2021
  • 1 location
Pembrolizumab in Post Radical Operation ESCC Patients With Lymph Node Positive ( KEYSTONE-004 )

The purpose of this study is to observe and evaluate the efficacy and safety of postoperative adjuvant treatment of pembrolizumab in patients with thoracic esophageal squamous cell carcinoma ESCC who have not received neoadjuvant therapy before undergoing R0 resection, and have positive postoperative lymph nodes.

  • 0 views
  • 09 May, 2021
  • 1 location
Study of ASP0739 Alone and With Pembrolizumab in Advanced Solid Tumors With NY-ESO-1 Expression Participants

The purpose of this study is to evaluate the safety, and tolerability of ASP0739, when administered as a single agent and in combination with pembrolizumab. This study will also evaluate the clinical response and other measures of anticancer activity of ASP0739 when administered as a single agent and in combination …

cancer of the ovary
intraperitoneal chemotherapy
squamous cell carcinoma
pembrolizumab
lung carcinoma
  • 0 views
  • 04 Jun, 2022
  • 5 locations
Phase Ib Study of TNO155 in Combination With Spartalizumab or Ribociclib in Selected Malignancies

This study is a Phase Ib, multi-center, open-label study of TNO155 in combination with spartalizumab or ribociclib with a dose escalation part followed by a dose expansion part in adult subjects with advanced solid tumors. These two treatment arms will enroll subjects in parallel to characterize the safety, tolerability, PK, …

progressive disease
ki-ras
cancer chemotherapy
cancer
EGFR
  • 19 views
  • 11 Apr, 2022
  • 8 locations
A Study of SAR444245 Combined With Other Anticancer Therapies for the Treatment of Participants With Gastrointestinal Cancer (Master Protocol) (Pegathor Gastrointestinal 203)

The study is a phase 2 non-randomized, open-label, multi-cohort, multi-center study assessing the clinical benefit of SAR444245 (THOR-707) combined with other anticancer therapies for the treatment of participants aged 18 years and older with advanced and metastatic gastrointestinal cancer. This study is structured as a master protocol for the investigation …

adenocarcinoma
gastrointestinal cancer
cetuximab
cancer
squamous cell carcinoma
  • 0 views
  • 07 Jun, 2022
  • 23 locations
A Study of SAR444245 Combined With Other Anticancer Therapies for the Treatment of Participants With Gastrointestinal Cancer (Master Protocol) (Pegathor Gastrointestinal 203)

The study is a phase 2 non-randomized, open-label, multi-cohort, multi-center study assessing the clinical benefit of SAR444245 (THOR-707) combined with other anticancer therapies for the treatment of participants aged 18 years and older with advanced and metastatic gastrointestinal cancer. This study is structured as a master protocol for the investigation …

gastrointestinal cancer
adenocarcinoma
cetuximab
cancer
squamous cell carcinoma
  • 4 views
  • 17 Jun, 2022
  • 30 locations
A First-in-Human JAB-8263 in Adult Patients With Advanced Tumors

This is a Phase 1/2a, first-in-human, open-label study of JAB-8263, this study has two parts: solid tumor dose escalation and expansion study and hematology tumor dose escalation and expansion study. These two parts will determine the maximum tolerated dose (MTD), recommended Phase 2 dose (RP2D) and assess the DLT of …

solid tumor
measurable disease
refractory acute myeloid leukemia (aml)
  • 0 views
  • 03 Aug, 2021
  • 1 location
A Study of KF-0210 in Advanced Solid Tumors Patients

The purpose of this Phase I, Multi-Center, Open-Label Study is to evaluate the safety, tolerability, Pharmacokinetics, Pharmacodynamics and anti-tumor activity of KF-0210 in participants with advanced solid tumors. The study will be conducted in two parts: phase Ia, and phase Ib.

measurable disease
atezolizumab
  • 5 views
  • 11 Sep, 2021
  • 1 location
Study of XB002 in Subjects With Solid Tumors (JEWEL-101)

This is a Phase 1, non-randomized, open-label, multicenter, dose-escalation and expansion study evaluating the safety, tolerability, PK, pharmacodynamics, and clinical antitumor activity of XB002 administered IV q3w alone and in combination with nivolumab to subjects with advanced solid tumors.

growth factors
breast cancer
ovarian epithelial carcinoma
ovarian cancer
peritoneal cancer
  • 0 views
  • 23 May, 2022
  • 5 locations
Longitudinal Oral Microbiome Sampling for BE

This is a longitudinal cohort study to assess the impact of repeated sampling of an oral microbiome signature for Barrett's esophagus (BE). Potential participants will be identified through chart review of patients who have had an endoscopy in the past three years.

endoscopy
Accepts healthy volunteers
metaplasia
intestinal metaplasia
  • 0 views
  • 01 Dec, 2021
  • 2 locations