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Found 363 clinical trials
Total Intravenous Anesthesia and Recurrence Free Survival

The investigators propose to compare recurrence-free survival in patients having potentially curative (Stages 1-3) surgery for esophageal cancer who will be randomly assigned to propofol-based

cancer
esophagus cancer
opioid
esophageal cancer
surgery for esophageal cancer
  • 0 views
  • 09 Sep, 2021
  • 1 location
Chemoradiotherapy in Esophageal or Esophagogastric Junction Cancer

Definitive chemoradiotherapy is the standard of care in unresectable esophageal or esophagogastric cancer. A multidisciplinary approach, including chemotherapy and radiotherapy, is important for these patients. Morerover, molecular targeting agents does not show clear efficacy in EC up to now. Nowadays, the pace of development of cancer immunotherapies is accelerating. Clinical …

  • 0 views
  • 06 Apr, 2021
  • 1 location
A Study of Multiple Immunotherapy-Based Treatment Combinations in Patients With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Cancer (G/GEJ) or Esophageal Cancer (Morpheus-Gastric and Esophageal Cancer)

combinations in patients with locally advanced unresectable or metastatic G/GEJ cancer (hereafter referred to as gastric cancer) and esophageal cancer. Two cohorts of patients with gastric cancer have been

  • 160 views
  • 27 Jun, 2022
  • 27 locations
High-flow Nasal Cannula Oxygenation Decrease Hypoxia in Sedated Gastrointestinal Endoscopes in Obesity

Hypoxia is the most common adverse event during gastrointestinal endoscopes sedated with propofol and sufentanil, especially in obese people. In the present study, high-flow nasal cannula oxygenation will be utilized in order to reduce the incidence of hypoxia among obesity.

propofol
  • 0 views
  • 27 Sep, 2021
  • 3 locations
RegoNivo vs Standard of Care Chemotherapy in AGOC (INTEGRATEIIb)

To determine if the regorafenib and nivolumab combination (RegoNivo) improves overall survival compared with current standard chemotherapy options in refractory AGOC.

  • 0 views
  • 21 Mar, 2022
  • 37 locations
Study Compare Adjuvant Chemotherapy Chemoradiotherapy and Surgery Alone for pN1-2(pT1b-3N1-2M0) Esophageal Carcinoma

A multi-center prospective randomized controlled study was conducted to compare the effects of adjuvant chemotherapy, chemoradiotherapy and surgery alone for the patients with esophageal cancer

chemotherapy regimen
chemoradiotherapy
esophageal cancer
antineoplastic
squamous cell carcinoma
  • 0 views
  • 20 Nov, 2021
  • 1 location
Augmented Response of Volatile Biomarkers in Assessment of Oesophagogastric Cancer (AROMA1)

Cancer of the stomach and oesophagus is among the world's top five cancers. Survival rates are very poor as the disease presents late and early symptoms are non-specific. The study team has developed a non-invasive test for cancers of the stomach and oesophagus based on the detection of volatile organic …

Accepts healthy volunteers
  • 0 views
  • 13 Jun, 2022
  • 1 location
PROCLAIM-CX-2029: A Trial to Find Safe and Active Doses of an Investigational Drug CX-2029 for Patients With Solid Tumors or DLBCL

The purpose of this first-in-human study of CX-2029 is to characterize the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and antitumor activity of CX-2029 in adult subjects with metastatic or locally advanced unresectable solid tumors or diffuse large B-cell lymphoma (DLBCL). The antitumor activity of CX-2029 will be evaluated in subjects …

lymphoma
solid tumour
carcinoma
adenocarcinoma
b-cell lymphoma
  • 95 views
  • 07 Apr, 2022
  • 19 locations
Capnographic Monitoring in Gastrointestinal Endoscopy for Elderly Patients (CapnoGI)

Hypoxia is the most common adverse event in gastrointestinal endoscopes sedated with propofol and sufentanil, especially in elderly people. The aim of this randomized study was to determine whether intervention based on additional capnographic monitoring reduces the incidence of hypoxia in gastrointestinal endoscopes procedures for elderly patients.

propofol
endoscopy
Accepts healthy volunteers
  • 0 views
  • 05 Apr, 2022
  • 3 locations
Sintilimab or Placebo With Chemotherapy in Esophageal Squamous Cell Carcinoma (ORIENT-15)

This is a randomized, double-blind multi-center, phase III study comparing the efficacy and safety of sintilimab or placebo in combination with chemotherapy as first-line treatment in subjects with unresectable, locally advanced recurrent or metastatic esophageal squamous cell carcinoma. After the interim analysis conducted by the iDMC, an open-label assignment of …

metastatic esophageal squamous cell carcinoma
chemotherapy regimen
chemoradiotherapy
sintilimab
squamous cell carcinoma
  • 41 views
  • 02 Mar, 2022
  • 42 locations