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Found 617 clinical trials
Study on the Relationship Between Pathological Features of Achalasia and Prognosis of Per-oral Endoscopic Myotomy

Achalasia is the most common motility disorder of esophagus, characterized by disorders of the lower esophageal sphincter (LES). Normal peristalsis of the esophagus is eliminated and replaced by synchronous or ineffective contraction. Based on high-resolution manometry (HRM), the participants with achalasia were categorized into 3 subtypes, type I: achalasia with …

  • 09 Jun, 2022
  • 1 location
Cardiopulmonary Toxicity of Thoracic Radiotherapy (CLARIFY)

Radiotherapy improves locoregional control and survival of thoracic tumour patients. However, the associated exposure of normal tissues, often leads to side effects and possibly even reduces survival. Indeed, there is growing evidence that overall survival after radiotherapy for lung and oesophageal cancer is related to the radiation dose to heart …

esophagus cancer
brain metastases
  • 09 Feb, 2022
  • 1 location
Transoral Incisionless Fundoplication Database Repository (TIF) (TIF)

Collect data on individuals who have a transoral incisionless fundoplication (TIF) performed by physicians at Indiana University for the treatment of gastroesophageal reflux disease.

  • 24 Mar, 2022
  • 1 location
Google Location History Following Oesophagectomy and/or Gastrectomy

Surgery is the mainstay of treatment for patients with early-disease esophageal and gastric cancer. Open surgery for oesophageal cancer commonly involves large incisions in the chest, which is associated with a high rate of respiratory complications in the postoperative period. Patients with oesophageal or gastric cancer furthermore commonly present with …

cancer chemotherapy
esophagus cancer
gastrointestinal cancer
Accepts healthy volunteers
  • 19 Apr, 2022
  • 1 location
Effects of Oral Cancer Treatments on Upper Esophageal Opening During Swallowing

The purpose of this study is to investigate pre-operative, post-operative and post-radiation upper esophageal sphincter opening measures in oral cancer patients, compare measures to ageand gender-matched healthy adults, and determine relationships with patient swallowing outcomes and quality of life.

oral cancer
  • 22 Sep, 2021
  • 1 location
Correlation Between Trans Esophageal Pressure and Non-invasive Mechanical Ventilation Failure in Patients With Acute Hypoxic Respiratory Failure (TEMPO)

This study aims at assessing the correlation between trans esophageal pressure and related respiratory mechanics (including, among others, nasal pressure-Pnose) and non-invasive mechanical ventilation failure in patients with acute hypoxic respiratory failure of different etiology (including COVID-19).

hypoxic respiratory failure
assisted ventilation
mechanical ventilation
respiratory failure
  • 21 Apr, 2022
  • 1 location
Upper GI Serial Tumour Biopsies

This is a prospective translational research study in which tumour samples, blood samples and other biospecimens will be requested from patients with locally advanced or metastatic malignant oesophageal and gastric carcinoma. There are two parts to the study: Part A - evaluation of serial tumour biopsies Part B - evaluation …

gastric carcinoma
blood cell count
endoscopic biopsy
  • 14 May, 2022
  • 1 location
Use and Acceptability Study of Swallis DSA™ Device for Distanced Swallowing Assessment for Older Adults In Nursing Home CHEZ LES PERSONNES AGEES EN EHPAD (SWALL EHPAD)

SWALL EHPAD is a multicenter, prospective study on the use and Acceptability Study of Swallis DSA™ Medical Device for Distanced Swallowing Assessment for Older Adults In Nursing Home

  • 15 Jun, 2022
  • 1 location
Feeding and Swallowing Problems in Infants With Laryngomalacia

Observational cross-sectional study Infants with laryngomalacia Feeding and swallowing assessment

  • 14 Jun, 2022
  • 1 location
LINX Reflux Management System or Fundoplication Clinical Study in Patients With Hiatal Hernia >3 cm

The cohort registry is both retrospective and prospective, multicenter surveillance of subjects who underwent a prior hiatal hernia repair and Magnetic Sphincter Augmentation or fundoplication construction more than 2 years prior to initial study visit.

  • 29 Aug, 2021
  • 4 locations