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Found 524 clinical trials
Total Intravenous Anesthesia and Recurrence Free Survival

The investigators propose to compare recurrence-free survival in patients having potentially curative (Stages 1-3) surgery for esophageal cancer who will be randomly assigned to propofol-based total intravenous anesthesia or sevoflurane-based balanced general anesthesia.

surgery for esophageal cancer
esophageal cancer
esophagus cancer
opioid
cancer
  • 0 views
  • 07 Oct, 2022
  • 1 location
Prospective Endoscopic Follow-up of Patients With Submucosal Esophageal Adenocarcinoma (The PREFER Trial)

Aim of this prospective multicenter study is to evaluate the safety of an endoscopic follow-up strategy in patients treated with endoscopic resection (ER) for submucosal or high-risk mucosal esophageal adenocarcinoma (T1bN0M0 or HR T1aN0M0 EAC).

esophageal adenocarcinoma
adenocarcinoma
endoscopic resection
  • 61 views
  • 29 Jan, 2021
  • 19 locations
An Open-label, Multi-center, Phase I, Dose Finding Study of Oral TNO155 in Adult Patients With Advanced Solid Tumors

The purpose of this first in human (FIH) trial is to characterize the safety and tolerability of the SHP2 inhibitor TNO155 alone and in combination with EGF816 (nazartinib) and identify a recommended dose for future studies in adult patients with advanced solid tumors in selected indications.

  • 297 views
  • 28 Oct, 2022
  • 11 locations
Comparing 61.2 Gy Radiotherapy Dose Versus 50.4 Gy Radiotherapy Dose for Locally Advanced Esophageal Carcinoma

The purpose of this study is to determined the best definitive radiotherapy dosage for patients with locally advanced esophageal squamous cell carcinoma.

neutrophil count
platelet count
esophageal carcinoma
metastasis
squamous cell carcinoma
  • 0 views
  • 04 Oct, 2022
  • 3 locations
Nasal Mask Kit in Gastrointestinal Endoscopy (NASO)

Hypoxia is the most common adverse event in gastrointestinal endoscopes sedated with propofol. The nasal mask oxygen kit has good sealing to ensure an adequate oxygen supply and is convenient and economical.The aim of this randomized study was to determine whether the nasal mask oxygen kit reduces the incidence of …

colonoscopy
propofol
Accepts healthy volunteers
KIT
endoscopy
  • 0 views
  • 07 Oct, 2022
  • 1 location
Comparison of Chemoradiotherapy and Chemoradiotherapy Combined With Consolidation Chemotherapy for ESCC

This study is a phase III, multicenter, prospective randomized controlled clinical study comparing the efficacy of non-surgical esophageal squamous cell carcinoma with radical chemoradiotherapy and radical chemoradiotherapy combined with consolidation chemotherapy. The survival time and side effects of patients were observed and compared.

  • 0 views
  • 11 Apr, 2023
  • 1 location
Capnographic Monitoring in Gastrointestinal Endoscopy for Elderly Patients (CapnoGI)

Hypoxia is the most common adverse event in gastrointestinal endoscopes sedated with propofol and sufentanil, especially in elderly people. The aim of this randomized study was to determine whether intervention based on additional capnographic monitoring reduces the incidence of hypoxia in gastrointestinal endoscopes procedures for elderly patients.

endoscopy
propofol
Accepts healthy volunteers
  • 0 views
  • 05 Apr, 2022
  • 3 locations
Minimally Invasive Molecular Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma

This study will evaluate if the sponge capsule device can accurately detect the presence of Barrett's Esophagus and prevalent dysplasia/adenocarcinoma detection, in a screening population, with and without chronic gastroesophageal reflux disease.

gastroesophageal reflux
Accepts healthy volunteers
dysplasia
metaplasia
esophageal adenocarcinoma
  • 6 views
  • 22 Oct, 2022
  • 6 locations
Seattle Biopsy Protocol Versus Wide-Area Transepithelial Sampling in Patients With Barrett's Esophagus Undergoing Surveillance (SWAT-BE)

The purpose of this research study is to learn about the best approach to sample patients with known or suspected Barrett's esophagus (BE) by comparing the standard Seattle biopsy protocol to sampling using wide area transepithelial sampling (WATS3D). Barrett's esophagus is a common condition that is used to spot patients …

esophageal adenocarcinoma
abnormal cells
dysplasia
endoscopy
esophagogastroduodenoscopy
  • 0 views
  • 12 Apr, 2023
  • 4 locations
A Study to Investigate the Safety and Tolerability of Intravenous QEQ278 in Patients With Advanced Solid Tumors

To characterize safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary anti-tumor activity of QEQ278 in adult patients with advanced/metastatic non-small cell lung cancer, esophageal squamous cell carcinoma, renal cell carcinoma, and human papilloma virus associated head and neck squamous cell carcinoma.

  • 0 views
  • 11 Apr, 2023
  • 6 locations