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Found 617 clinical trials
Prospective Endoscopic Follow-up of Patients With Submucosal Esophageal Adenocarcinoma (The PREFER Trial)

Aim of this prospective multicenter study is to evaluate the safety of an endoscopic follow-up strategy in patients treated with endoscopic resection (ER) for submucosal or high-risk mucosal esophageal adenocarcinoma (T1bN0M0 or HR T1aN0M0 EAC).

endoscopic resection
esophageal adenocarcinoma
adenocarcinoma
  • 61 views
  • 29 Jan, 2021
  • 19 locations
Study Compare Adjuvant Chemotherapy Chemoradiotherapy and Surgery Alone for pN1-2(pT1b-3N1-2M0) Esophageal Carcinoma

A multi-center prospective randomized controlled study was conducted to compare the effects of adjuvant chemotherapy, chemoradiotherapy and surgery alone for the patients with esophageal cancer.

chemoradiotherapy
esophagus cancer
esophageal cancer
antineoplastic
carcinoma
  • 0 views
  • 20 Nov, 2021
  • 1 location
Minimally Invasive Molecular Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma

This study will evaluate if the sponge capsule device can accurately detect the presence of Barrett's Esophagus and prevalent dysplasia/adenocarcinoma detection, in a screening population, with and without chronic gastroesophageal reflux disease.

gastroesophageal reflux
endoscopy
adenocarcinoma
dysplasia
intestinal metaplasia
  • 6 views
  • 10 Oct, 2021
  • 6 locations
Performance of White Light, NBI and Iodine Staining Endoscopy in the Diagnosis of Esophageal Lesions

The investigators aim to evaluate the performance of Narrow Band Imaging (NBI) endoscopy in Esophageal Squamous Cell Carcinoma (ESCC) screening, as compared to the currently used White Light Endoscopy (WLE) and Lugol's Iodine Staining Endoscopy (ISE). NBI is a simple, safe and non-invasive technique, which can provide real-time optical staining …

Accepts healthy volunteers
endoscopy
squamous cell carcinoma
carcinoma
  • 0 views
  • 18 Feb, 2022
  • 2 locations
Accuracy of Magnetically Maneuvered Capsule Endoscopy for Detection of GEV in Patients With Cirrhosis

This is a non-interventional diagnostic accuracy study. Using EGD as the golden standard, to assess the accuracy of the ds-MCE in identifying and grading gastroesophageal varices in patients undergoing screening or surveillance for gastroesophageal varices. And the efficacy of the ds-MCE in detecting various pathological changes of cirrhosis in small …

varicose veins
endoscopy
cirrhosis
gastroesophageal varices
  • 0 views
  • 17 Feb, 2022
  • 2 locations
Comparing 61.2 Gy Radiotherapy Dose Versus 50.4 Gy Radiotherapy Dose for Locally Advanced Esophageal Carcinoma

The purpose of this study is to determined the best definitive radiotherapy dosage for patients with locally advanced esophageal squamous cell carcinoma.

positron emission tomography/computed tomography
pet-ct scan
neutrophil count
carcinoma
esophageal carcinoma
  • 0 views
  • 26 Mar, 2022
  • 3 locations
Chemoradiotherapy in Esophageal or Esophagogastric Junction Cancer

Definitive chemoradiotherapy is the standard of care in unresectable esophageal or esophagogastric cancer. A multidisciplinary approach, including chemotherapy and radiotherapy, is important for these patients. Morerover, molecular targeting agents does not show clear efficacy in EC up to now. Nowadays, the pace of development of cancer immunotherapies is accelerating. Clinical …

  • 0 views
  • 06 Apr, 2021
  • 1 location
Capnographic Monitoring in Gastrointestinal Endoscopy for Elderly Patients (CapnoGI)

Hypoxia is the most common adverse event in gastrointestinal endoscopes sedated with propofol and sufentanil, especially in elderly people. The aim of this randomized study was to determine whether intervention based on additional capnographic monitoring reduces the incidence of hypoxia in gastrointestinal endoscopes procedures for elderly patients.

Accepts healthy volunteers
endoscopy
propofol
  • 0 views
  • 05 Apr, 2022
  • 3 locations
Dose Finding Study of TNO155 in Adult Patients With Advanced Solid Tumors

The purpose of this first in human (FIH) trial is to characterize the safety and tolerability of the SHP2 inhibitor TNO155 alone and in combination with EGF816 (nazartinib) and identify a recommended dose for future studies in adult patients with advanced solid tumors in selected indications.

  • 297 views
  • 13 Apr, 2022
  • 12 locations
Chemoradiotherapy Followed by Planned Surgery or by Surveillance and Surgery Only When Needed for Oesophageal Cancer (NEEDS)

NEEDS is a pragmatic open-label, randomised, controlled, phase III, multicenter trial with non-inferiority design with regard to the primary endpoint overall survival and superiority for the experimental intervention definitive chemoradiotherapy with regard to the main secondary endpoint global health related quality of life (HRQOL) one year after randomisation. The aim …

folfox regimen
oxaliplatin
chemoradiotherapy
esophagectomy
esophagus cancer
  • 0 views
  • 23 Apr, 2022
  • 8 locations