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Found 375 clinical trials
Study of Pembrolizumab (MK-3475) Versus Placebo in Participants With Esophageal Carcinoma Who Are Receiving Chemotherapy and Radiation Therapy (MK-3475-975/KEYNOTE-975)

The purpose of this study is to assess the efficacy and safety of treatment with definitive chemoradiotherapy (dCRT) + pembrolizumab (MK-3475) compared to treatment with dCRT + placebo with respect to Overall Survival (OS) and Event-free Survival (EFS) in: participants with esophageal squamous cell carcinoma (ESCC), participants whose tumors express …

leucovorin
chemotherapy regimen
ebrt
carcinoma
adenocarcinoma
  • 62 views
  • 14 Jun, 2022
  • 141 locations
Augmented Response of Volatile Biomarkers in Assessment of Oesophagogastric Cancer (AROMA1)

Cancer of the stomach and oesophagus is among the world's top five cancers. Survival rates are very poor as the disease presents late and early symptoms are non-specific. The study team has developed a non-invasive test for cancers of the stomach and oesophagus based on the detection of volatile organic …

Accepts healthy volunteers
  • 0 views
  • 13 Jun, 2022
  • 1 location
A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers (HERIZON-GEA-01)

patients in this study will have advanced human epidermal growth factor 2 (HER2)-positive stomach and esophageal cancers that are no longer treatable with surgery (unresectable) or chemoradiation, and/or

cancer chemotherapy
erbb2
capecitabine
fluorouracil
human epidermal growth factor
  • 0 views
  • 16 Jun, 2022
  • 128 locations
Performance of White Light, NBI and Iodine Staining Endoscopy in the Diagnosis of Esophageal Lesions

The investigators aim to evaluate the performance of Narrow Band Imaging (NBI) endoscopy in Esophageal Squamous Cell Carcinoma (ESCC) screening, as compared to the currently used White Light Endoscopy (WLE) and Lugol's Iodine Staining Endoscopy (ISE). NBI is a simple, safe and non-invasive technique, which can provide real-time optical staining …

Accepts healthy volunteers
carcinoma
endoscopy
squamous cell carcinoma
  • 0 views
  • 18 Feb, 2022
  • 2 locations
Dose Escalation Study of a PD1-LAG3 Bispecific Antibody in Patients With Advanced and/or Metastatic Solid Tumors

This is a first-in-human, open-label, multicenter, Phase I multiple-ascending dose (MAD) study of RO7247669, an anti PD-1 (programmed death-1) and LAG-3 (Lymphocyte-activation gene 3) bispecific antibody, for participants with advanced and/or metastatic solid tumors. This study aims to establish the maximum tolerated dose (MTD) and/or define the recommended phase 2 …

solid tumors
lung cancer
lung carcinoma
carcinoma
squamous cell carcinoma
  • 14 views
  • 13 Jun, 2022
  • 17 locations
A Study of SGN-STNV in Advanced Solid Tumors

This trial will look at a drug called SGN-STNV to find out whether it is safe for patients with solid tumors. It will study SGN-STNV to find out what its side effects are. A side effect is anything the drug does besides treating cancer. It will also study how well …

cancer chemotherapy
human chorionic gonadotropin
carcinoma
adenocarcinoma
cancer
  • 0 views
  • 30 May, 2022
  • 15 locations
Onco-primary Care Networking to Support TEAM-based Care (ONE TEAM)

The proposed ONE TEAM Study is an 18-month, cluster randomized controlled trial. This study will use a sequential multiple assignment randomized trial (SMART) design with a second randomization for the intervention group using a dynamic treatment regimen approach. The investigators propose to randomize 800 adults with newly-diagnosed selected cancers treated …

a 12
hypercholesterolemia
cardiovascular disease
chronic disease
type 2 diabetes mellitus
  • 0 views
  • 09 Jun, 2022
  • 1 location
Stereotactic Body Radiotherapy in Patients With Rare Oligometastatic Cancers (OligoRARE) (OligoRARE)

This is a randomized open-label multicentre Phase III superiority study of the effect of adding SBRT to the standard of care treatment on overall survival in patients with rare oligometastatic cancers. Patients will be randomized in a 1:1 ratio between current standard of care treatment vs. standard of care treatment …

brain metastases
systemic therapy
metastasis
  • 0 views
  • 26 May, 2022
  • 7 locations
A Study of SGN-B6A in Advanced Solid Tumors

This trial will look at a drug called SGN-B6A to find out whether it is safe for people who have solid tumors. It will study SGN-B6A to find out what its side effects are. A side effect is anything the drug does besides treating cancer. It will also study whether …

carcinoma
adenocarcinoma
HER2
squamous cell carcinoma
cancer
  • 179 views
  • 19 Jun, 2022
  • 12 locations
A Study of SAR444245 Combined With Other Anticancer Therapies for the Treatment of Participants With Gastrointestinal Cancer (Master Protocol) (Pegathor Gastrointestinal 203)

The study is a phase 2 non-randomized, open-label, multi-cohort, multi-center study assessing the clinical benefit of SAR444245 (THOR-707) combined with other anticancer therapies for the treatment of participants aged 18 years and older with advanced and metastatic gastrointestinal cancer. This study is structured as a master protocol for the investigation …

carcinoma
squamous cell carcinoma
esophageal cancer
adenocarcinoma
cancer
  • 0 views
  • 07 Jun, 2022
  • 23 locations