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Found 411 clinical trials
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A Phase 1 Open-Label, Dose-Escalation, Safety and Tolerability Study of INCAGN02385 in Participants With Select Advanced Malignancies

The purpose of this study is to determine the safety, tolerability, and preliminary efficacy of INCAGN02385 in participants with advanced malignancies.  This investigational intervention treatment uses a single biological drug and is conducted in two parts. Part 1: INCAGN02385 at the protocol-defined starting dose administered every 2 weeks (Q2W), with dose …

urothelial carcinoma
carcinoma
ovarian cancer
metastatic cervical cancer
  • 156 views
  • 23 Nov, 2020
  • 4 locations
featured
A Phase 1, Open-Label, Dose-Escalation, Safety and Tolerability Study of INCAGN02390 in Participants With Select Advanced Malignancies

The purpose of this study is to determine the safety, tolerability, and preliminary efficacy of INCAGN02390 in participants with advanced malignancies. This investigational intervention treatment uses a single biological drug and is conducted in two parts. Part 1: INCAGN02390 at the protocol-defined starting dose administered every 2 weeks (Q2W), with …

cancer
advanced cancer
  • 128 views
  • 14 Dec, 2020
  • 4 locations
Combination Chemotherapy in Treating Patients With Esophageal Cancer

yet known which regimen of combination chemotherapy is more effective in treating esophageal cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of two regimens of

surgery for esophageal cancer
tumor cells
conventional surgery
combination chemotherapy
epirubicin
  • 31 views
  • 07 Nov, 2020
  • 1 location
Three Field Radical Esophagectomy Versus Two Field Esophagectomy - a Prospective Trial

Surgery is the standard treatment for esophageal (food pipe) cancer. Esophageal cancer is known to spread to the lymph nodes (glands) adjacent to the esophagus. The extent of lymph nodes

adenocarcinoma
esophagectomy
cancer
lymphadenectomy
esophageal cancer
  • 15 views
  • 07 Nov, 2020
  • 1 location
Study of SHR-1210 in Combination With Chemotherapy in Advanced Esophageal Cancer

1L therapy for advanced esophageal cancer patients in China. SHR-1210 is a humanized anti-PD1 IgG4 monoclonal antibody.

  • 0 views
  • 22 Jan, 2021
  • 1 location
Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) Plus Chemotherapy in Participants With Metastatic Esophageal Carcinoma (MK-7902-014/E7080-G000-320/LEAP-014)

participants with metastatic esophageal carcinoma The primary hypotheses are that pembrolizumab plus lenvatinib plus chemotherapy is superior to pembrolizumab plus chemotherapy with respect to overall

  • 0 views
  • 22 Sep, 2021
  • 5 locations
A Study to Evaluate the Safety Pharmacokinetics Pharmacodynamics and Clinical Activity of JNJ-63723283 an Anti-PD-1 Monoclonal Antibody in Participants With Advanced Cancers

participants with selected advanced cancers including non-small-cell lung cancer (NSCLC), melanoma, renal, bladder, small-cell lung cancer (SCLC), gastric/esophageal cancer, and high-level microsatellite

lung cancer
monoclonal antibodies
primary cancer
  • 49 views
  • 15 Sep, 2021
  • 35 locations
Radiotherapy & Olaparib in COmbination for Carcinoma of the Oesophagus

The purpose of this study is to determine the Maximum Tolerated Dose (MTD) of olaparib in combination with radical radiotherapy in patients with oesophageal cancer who are unsuitable for

chemoradiotherapy
esophagus cancer
platelet count
neutrophil count
oesophageal stent
  • 2 views
  • 08 Nov, 2020
FOLFIRI as Second Line Chemotherapy for Metastatic Esophageal Carcinoma

This phase study was designed to evaluate the efficacy and safety of FOLFIRI as second-line treatment for metastatic esophageal carcinoma.

  • 7 views
  • 23 Jan, 2021
  • 1 location
Combination of Chemoradiation Therapy and Epitope Peptide Vaccine Therapy in Treating Patients With Esophageal Cancer

chemotherapy (CDDP, 5-FU) plus radiation therapy in treating patients with unresectable, advanced or recurrent esophageal cancer.

peptide vaccine
chemoradiotherapy
platelet count
recurrent esophageal cancer
VEGFR2
  • 11 views
  • 07 Nov, 2020
  • 1 location