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Found 49 clinical trials
Eltrombopag Added to Standard Immunosuppression in Treatment-Naive Severe Aplastic Anemia

Background: Severe aplastic anemia is a rare and serious blood disorder. It happens when the immune system starts to attack the bone marrow cells. This causes the bone marrow to stop making red blood cells, platelets, and white blood cells. Standard treatment for this disease is horse-ATG and cyclosporine, which …

aplastic anemia
anemia studies
myelodysplastic syndrome (mds)
myelodysplastic syndromes
  • 22 Dec, 2020
  • 1 location
Erythropoietin in Premature Infants to Prevent Encephalopathy

The main goal of this trial is to investigate whether early administration of human erythropoietin (EPO) in preterm infants improves neurodevelopmental outcome at 18 months corrected age. This

  • 15 Mar, 2021
  • 1 location
Relationship Between Erythropoietin Administration and Stress Responses in Trauma Patients

The purpose of this study is to determine whether Erythropoietin decrease stress responses and inflammation in trauma patient.

  • 07 Nov, 2020
  • 1 location
Effects of Intravenous Injection of Erythropoietin on Hepcidin Pharmacokinetics in Healthy Volunteers

The aim of this study is to measure the variations of serum and urinary hepcidin levels following a single intravenous injection of erythropoietin in healthy volunteers. Hepcidin is a

  • 07 Nov, 2020
  • 1 location
A Study to Investigate the Effect of Roxadustat Versus Recombinant Human Erythropoietin (rHuEPO) on Oral Iron Absorption in Chinese Patients With Anemia of Chronic Kidney Disease (CKD)

This is a Phase IV, randomized, active-controlled, open-label, parallel design, multicenter prospective study to evaluate the effect of roxadustat versus rHuEPO treatment on the gastrointestinal (GI) iron absorption in patients with anemia of Stage 4 and Stage 5 CKD. This study is planned to screen approximately 104 patients and randomize …

  • 09 May, 2021
  • 6 locations
Iron Isomaltoside Compared With Iron Sucrosein Peritoneal Dialysis Patients

To compare patient-reported satisfaction, efficacy and short-term safety profile of Monofer in a single bolus dose with Venofer in split doses in the treatment of absolute or functional iron deficiency anemia in patients on PD. To compare patient symptomatology on fatigue after treatment of Monofer compared with Venofer .

  • 23 Jan, 2021
Eltrombopag+hATG+CsA vs. hATG+CsA in Children With Severe AA

The analysis of our own clinical data suggests that majority of the hematologic responses observed after the course of h-ATG/CsA is partial, and about 10% tend to have cyclosporine dependence. The aim of the current study is to improve the rate and the quality of hematologic response as well as …

  • 21 Mar, 2021
  • 1 location
Safety and Efficacy Study of Sotatercept in Adults With Transfusion Dependent Diamond Blackfan Anemia

The purpose of this study is to determine the safety and dosing of drug Sotatercept, as a subcutaneous injection, to stimulate production of red blood cell production. To be given every 28 days for up to four doses.

  • 14 Mar, 2021
  • 1 location
Role of Blood Management in Perioperative Outcomes

There is currently limited information regarding the role of blood management in the benign gynecologic population and specifically, in patients who are scheduled to undergo surgery for fibroids and/or abnormal uterine bleeding. A thorough search through PubMed and did not reveal any studies on this issue. In 2019 at …

  • 03 Feb, 2021
  • 1 location
ErythroPOietin Alfa to Prevent Mortality and Reduce Severe Disability in Critically Ill TRAUMA Patients

The EPO-TRAUMA study is a prospective, multi-centre, double-blind, phase III, randomised controlled trial evaluating the efficacy of epoetin alfa compared to placebo in reducing mortality and severe disability at six months in critically ill trauma patients. 2500 mechanically ventilated ICU patients admitted with a primary trauma diagnosis presenting to the …

  • 26 Jan, 2021
  • 17 locations