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Found 41 clinical trials
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Eltrombopag Added to Standard Immunosuppression in Treatment-Naive Severe Aplastic Anemia

Background: Severe aplastic anemia is a rare and serious blood disorder. It happens when the immune system starts to attack the bone marrow cells. This causes the bone marrow to stop making red blood cells, platelets, and white blood cells. Standard treatment for this disease is horse-ATG and cyclosporine, which …

aplastic anemia
myelodysplastic syndrome (mds)
anemia studies
myelodysplastic syndromes
  • 22 Dec, 2020
  • 1 location
Erythropoietin in Premature Infants to Prevent Encephalopathy

The main goal of this trial is to investigate whether early administration of human erythropoietin (EPO) in preterm infants improves neurodevelopmental outcome at 18 months corrected age. This

  • 22 Jan, 2022
  • 1 location
Erythropoietin Therapy to Induce Regulatory T Cells in Liver Transplant Recipients

The hypothesis of this proof-of-concept study is that EPO increases the frequency, stability and/or function of Tregs in liver transplant recipients. We also hypothesize that EPO will have a greater effect in everolimus vs. tacrolimus treated LTR, thus providing the rationale for a subsequent clinical trial to utilize EPO in …

  • 02 May, 2022
  • 1 location
Pharmacological Countermeasures for High Altitude

The aim of this randomized, double-blind study is to determine whether erythropoietin (Procrit) and acetazolamide: 1) mitigates altitude-induced decrements in performance at moderate altitude

Accepts healthy volunteers
  • 23 Apr, 2022
  • 1 location
A Study of YPEG-rhEPO in Patients Suffered From Anemia Due to Chronic Kidney Disease

The purpose of this study is to evaluate the effectiveness and safety of YPEG rhEPO, a recombinant human erythropoietin pegylated by Y shape polyethylene glycol, in patients with anemia due to

  • 26 May, 2021
  • 17 locations
Physical Exercise and Responses Measured by HIF-1 in COPD

changes in the nuclear concentrations of HIF-1, affecting the transcriptional mechanisms of specific genes for Erythropoietin (EPO), the Factor of Vascular Endothelial Growth (VEFG) and therefore limit

  • 03 Sep, 2021
  • 1 location
Eltrombopag+hATG+CsA vs. hATG+CsA in Children With Severe AA

The analysis of our own clinical data suggests that majority of the hematologic responses observed after the course of h-ATG/CsA is partial, and about 10% tend to have cyclosporine dependence. The aim of the current study is to improve the rate and the quality of hematologic response as well as …

  • 26 Feb, 2022
  • 1 location
Postoperative Replacement of Intraoperative Iron Losses (POREIIL)

By performing a randomized, blinded placebo controlled exploratory trial we speculate that replacement of perioperative, bleeding-induced iron losses with ferric carboxymaltose immediately after the surgical procedure can replenish iron with increased hemoglobin levels and reduce the amount of pRBCs transfused in the postoperative period (30 days post surgery).

  • 19 Apr, 2022
  • 1 location
Importance of Blood Volume and Its Interaction With Cardiovascular Adaptations

The present project aims to investigate the interaction between training-induced blood volume expansion (plasma- and red blood cell volume responses), central as well as peripheral cardio-vascular adaptations. We will investigate cardiovascular responses through one year of training in recreationally active men and women as well as endurance athletes undertaking shorter …

Accepts healthy volunteers
  • 25 May, 2022
  • 2 locations
Role of Blood Management in Perioperative Outcomes

There is currently limited information regarding the role of blood management in the benign gynecologic population and specifically, in patients who are scheduled to undergo surgery for fibroids and/or abnormal uterine bleeding. A thorough search through PubMed and did not reveal any studies on this issue. In 2019 at …

  • 25 Mar, 2022
  • 1 location