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Found 10 clinical trials
A Phase 3 Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in Subjects With Advanced Urothelial Cancer and Selected FGFR Gene Aberrations (THOR)

The purpose of this study is to evaluate efficacy of erdafitinib versus chemotherapy or pembrolizumab in participants with advanced urothelial cancer harboring selected fibroblast growth factor

pembrolizumab
renal function
growth factor
docetaxel
adjuvant chemotherapy
  • 297 views
  • 20 Sep, 2022
  • 307 locations
A Phase 2 Study of Erdafitinib in Subjects With Advanced Solid Tumors and FGFR Gene Alterations (RAGNAR)

The purpose of this study is to evaluate the efficacy of erdafitinib in terms of overall response rate (ORR) in adult and pediatric participants with advanced solid tumors with fibroblast growth

cancer
measurable disease
growth factor
solid tumour
  • 39 views
  • 22 Sep, 2022
  • 149 locations
A Phase 1b-2 Study to Evaluate Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of Various Regimens of Erdafitinib in Subjects With Metastatic or Locally Advanced Urothelial Cancer

The purpose of this study is to: (a) characterize the safety and tolerability of and to identify the recommended Phase 2 dose (RP2D) and schedule for erdafitinib in combination with cetrelimab

neuropathy
solid tumour
renal function
measurable disease
hearing loss
  • 100 views
  • 14 Sep, 2022
  • 58 locations
A Randomized Phase 2 Study of Erdafitinib Versus Investigator Choice of Intravesical Chemotherapy in Subjects Who Received Bacillus Calmette-Guérin (BCG) and Recurred With High Risk Non-Muscle-Invasive Bladder Cancer (NMIBC) and FGFR Mutations or Fusions

The purpose of this study is to evaluate recurrence-free survival (RFS) in participants treated with erdafitinib vs Investigator's Choice, for participants with high-risk non-muscle-invasive

growth factor
bladder tumor
invasive bladder cancer
gemcitabine
mitomycin
  • 0 views
  • 20 Sep, 2022
  • 143 locations
Erdafitinib for the Treatment of Patients With Castration-Resistant Prostate Cancer

This phase II trial studies the effect of erdafitinib in treating patients with prostate cancer that grows and continues to spread despite the surgical removal of the testes or drugs to block

  • 0 views
  • 04 Oct, 2022
  • 1 location
A Study of Oral Erdafitinib in People With Recurrent Non-Invasive Bladder Cancer

The purpose of this study is to assess the effectiveness of erdafitinib in people with non-muscle invasive bladder cancer (NMIBC) that has come back after standard treatment, such as Bacillus

transurethral resection
neutrophil count
FGFR3
bladder tumor
invasive bladder cancer
  • 0 views
  • 04 Oct, 2022
  • 7 locations
Erdafitinib and Abiraterone Acetate or Enzalutamide in Treating Patients With Double Negative Prostate Cancer

This phase II trial studies how well erdafitinib in combination with abiraterone acetate or enzalutamide works in treating patients with double negative prostate cancer. Erdafitinib may stop the

adenocarcinoma
liver metastasis
adenocarcinoma of prostate
neutrophil count
measurable disease
  • 0 views
  • 16 May, 2022
  • 1 location
Testing Combination Erdafitinib and Enfortumab Vedotin in Metastatic Bladder Cancer After Treatment With Chemotherapy and Immunotherapy

This phase Ib trial evaluates the best dose, potential benefits, and/or side effects of erdafitinib in combination with enfortumab vedotin in treating patients with bladder cancer that has

  • 0 views
  • 10 Jul, 2022
  • 1 location
Phase 1 Study of Erdafitinib Intravesical Delivery System (TAR-210) in Participants With Non- Muscle-Invasive or Muscle-Invasive Bladder Cancer and Selected FGFR Mutations or Fusions

The purpose of the study in Part 1 (dose escalation) is to determine the recommended Phase 2 dose(s) (RP2D[s]) and in Part 2 (dose expansion) is to determine the safety of Erdafitinib

carcinoma
bladder tumor
radical cystectomy
  • 0 views
  • 19 Sep, 2022
  • 7 locations
  • 13 views
  • 21 Sep, 2022
  • 3 locations