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Found 11 clinical trials
An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With Urothelial Cancer

The purpose of this study is to evaluate the objective response rate (complete response [CR]+ partial response [PR]) of the selected dose regimen in participants with metastatic or surgically unresectable urothelial cancers that harbor specific FGFR genomic alterations.

dose regimen
measurable disease
renal function
erdafitinib
adjuvant chemotherapy
  • 40 views
  • 08 Jan, 2021
  • 147 locations
A Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in Participants With Advanced Urothelial Cancer and Selected Fibroblast Growth Factor Receptor (FGFR) Gene Aberrations

The purpose of this study is to evaluate efficacy of erdafitinib versus chemotherapy or pembrolizumab in participants with advanced urothelial cancer harboring selected fibroblast growth factor

vinflunine
growth factor
transitional cell carcinoma
carcinoma
adjuvant chemotherapy
  • 271 views
  • 12 Oct, 2020
  • 523 locations
A Study to Evaluate the Effect of Hepatic Impairment on the Pharmacokinetics of Erdafitinib

The primary purpose of the study is to characterize the single dose pharmacokinetic of erdafitinib in participants with impaired hepatic function relative to participants with normal hepatic

human chorionic gonadotropin
beta human chorionic gonadotropin
erdafitinib
bilateral oophorectomy
drug tests
  • 0 views
  • 18 Nov, 2020
  • 5 locations
  • 0 views
  • 12 Dec, 2020
  • 1 location
A Study of Erdafitinib in Participants With Metastatic or Locally Advanced Urothelial Cancer

The purpose of this study is to: (a) characterize the safety and tolerability of and to identify the recommended Phase 2 dose (RP2D) and schedule for erdafitinib in combination with cetrelimab

measurable disease
neuropathy
systemic therapy
cancer
carboplatin
  • 95 views
  • 06 Jan, 2021
  • 193 locations
A Study of Erdafitinib in Participants With Advanced Solid Tumors and Fibroblast Growth Factor Receptor (FGFR) Gene Alterations

The purpose of this study is to evaluate the efficacy of erdafitinib in terms of overall response rate (ORR) in participants with advanced solid tumors with fibroblast growth factor receptor

cancer
measurable disease
solid tumour
growth factor
  • 33 views
  • 09 Jan, 2021
  • 258 locations
A Study of Erdafitinib Versus Investigator Choice of Intravesical Chemotherapy in Participants Who Received Bacillus Calmette-Gu rin (BCG) and Recurred With High Risk Non-Muscle-Invasive Bladder Cancer (NMIBC)

The purpose of this study is to evaluate recurrence-free survival (RFS) in participants treated with erdafitinib vs Investigator's Choice, for participants with high-risk non-muscle-invasive

invasive bladder cancer
bladder tumor
bcg vaccine
transitional cell carcinoma
human chorionic gonadotropin
  • 0 views
  • 09 Jan, 2021
  • 174 locations
Erdafitinib and Abiraterone Acetate or Enzalutamide in Treating Patients With Double Negative Prostate Cancer

This phase II trial studies how well erdafitinib in combination with abiraterone acetate or enzalutamide works in treating patients with double negative prostate cancer. Erdafitinib may stop the

gilbert's syndrome
measurable disease
direct bilirubin
liver metastasis
adenocarcinoma of prostate
  • 0 views
  • 05 Oct, 2020
  • 1 location
Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors Non-Hodgkin Lymphoma or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial)

This phase II Pediatric MATCH trial studies how well erdafitinib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders that have spread to other places in

ascites
blood transfusion
platelet transfusion
solid tumors
interleukins
  • 261 views
  • 17 Jan, 2021
  • 80 locations
  • 12 views
  • 06 Jul, 2020
  • 2 locations