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Found 13 clinical trials
An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With Urothelial Cancer

The purpose of this study is to evaluate the objective response rate (complete response [CR]+ partial response [PR]) of the selected dose regimen in participants with metastatic or surgically unresectable urothelial cancers that harbor specific FGFR genomic alterations.

measurable disease
erdafitinib
adjuvant chemotherapy
dose regimen
renal function
  • 42 views
  • 12 May, 2022
  • 18 locations
A Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in Participants With Advanced Urothelial Cancer and Selected Fibroblast Growth Factor Receptor (FGFR) Gene Aberrations

The purpose of this study is to evaluate efficacy of erdafitinib versus chemotherapy or pembrolizumab in participants with advanced urothelial cancer harboring selected fibroblast growth factor

growth factor
erdafitinib
docetaxel
advanced urothelial carcinoma
pembrolizumab
  • 289 views
  • 03 May, 2022
  • 336 locations
A Study of Steady-state Carbamazepine on the Single-dose of Erdafitinib Tablets in Healthy Adult Participants

a single oral dose of erdafitinib in healthy adult participants.

Accepts healthy volunteers
  • 230 views
  • 15 Mar, 2022
  • 1 location
A Study of Erdafitinib in Participants With Metastatic or Locally Advanced Urothelial Cancer

The purpose of this study is to: (a) characterize the safety and tolerability of and to identify the recommended Phase 2 dose (RP2D) and schedule for erdafitinib in combination with cetrelimab

hearing loss
measurable disease
neuropathy
growth factor
systemic therapy
  • 100 views
  • 09 May, 2022
  • 101 locations
A Study of Erdafitinib in Participants With Advanced Solid Tumors and Fibroblast Growth Factor Receptor (FGFR) Gene Alterations

The purpose of this study is to evaluate the efficacy of erdafitinib in terms of overall response rate (ORR) in adult and pediatric participants with advanced solid tumors with fibroblast growth

measurable disease
growth factor
cancer
solid tumour
  • 39 views
  • 06 May, 2022
  • 165 locations
A Study of Erdafitinib Versus Investigator Choice of Intravesical Chemotherapy in Participants Who Received Bacillus Calmette-Guérin (BCG) and Recurred With High Risk Non-Muscle-Invasive Bladder Cancer (NMIBC)

The purpose of this study is to evaluate recurrence-free survival (RFS) in participants treated with erdafitinib vs Investigator's Choice, for participants with high-risk non-muscle-invasive

bladder tumor
intravesical chemotherapy
bcg vaccine
growth factor
mitomycin
  • 0 views
  • 15 May, 2022
  • 148 locations
Study of Erdafitinib Intravesical Delivery System for Localized Bladder Cancer

The purpose of the study in Part 1 (dose escalation) is to determine the recommended Phase 2 dose(s) (RP2D[s]) and in Part 2 (dose expansion) is to determine the safety of Erdafitinib

  • 0 views
  • 02 May, 2022
  • 3 locations
Testing Combination Erdafitinib and Enfortumab Vedotin in Metastatic Bladder Cancer After Treatment With Chemotherapy and Immunotherapy

This phase Ib trial evaluates the best dose, potential benefits, and/or side effects of erdafitinib in combination with enfortumab vedotin in treating patients with bladder cancer that has

  • 0 views
  • 09 Dec, 2021
  • 2 locations
Erdafitinib for the Treatment of Patients With Castration-Resistant Prostate Cancer

This phase II trial studies the effect of erdafitinib in treating patients with prostate cancer that grows and continues to spread despite the surgical removal of the testes or drugs to block

  • 0 views
  • 03 Dec, 2021
  • 1 location
A Study of Oral Erdafitinib in People With Recurrent Non-Invasive Bladder Cancer

The purpose of this study is to assess the effectiveness of erdafitinib in people with non-muscle invasive bladder cancer (NMIBC) that has come back after standard treatment, such as Bacillus

bladder tumor
intravesical chemotherapy
neutrophil count
mitomycin
FGFR3
  • 0 views
  • 10 May, 2022
  • 7 locations