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Found 21 clinical trials
Radiotherapy Omission in Low Risk Ductal in Situ Carcinoma Breast

suggested that low proliferation, hormone receptors expression, and lack of ERBB2 amplification were associated with a low risk of IBR in patients not receiving radiotherapy. A combined signature was tested

human epidermal growth factor
lobular carcinoma in situ
growth factor
ductal carcinoma
cish
  • 15 views
  • 25 Jan, 2021
  • 13 locations
Tucatinib Plus Trastuzumab in Patients With HER2+ Colorectal Cancer

This trial studies how well the drug tucatinib works when given with trastuzumab and when given by itself. The participants in this trial have HER2-positive (HER2+) metastatic colorectal cancer (mCRC). 'Metastatic' means that the cancer has spread to other parts of the body. In the first part of this study, …

capecitabine
trastuzumab
vascular endothelial growth factor
measurable disease
monoclonal antibodies
  • 308 views
  • 06 Jun, 2021
  • 80 locations
Targeting EGFR/ERBB2 With Neratinib in Hormone Receptor (HR)-Positive/HER2-negative HER2-enriched Advanced/Metastatic Breast Cancer

HR+/HER2-negative BC represent 70% of all newly diagnosed breast tumours and are responsible for most recurrences and deaths due to this disease, and despite available standard therapies, 15-20% of hormone tumours recur at distant sites. As BC is a clinically and biologically heterogeneous disease, intrincsic subtype may play an important …

stage iv breast cancer
core needle biopsy
measurable disease
hormone therapy
estradiol
  • 0 views
  • 26 Jan, 2021
  • 15 locations
Omission of Surgery in Clinically Low-risk HER2positive Breast Cancer With High HER2 Addiction and a Complete Response Following Standard Anti-HER2-based Neoadjuvant Therapy

This is a prospective, single arm, open-label, unicenter, exploratory study in women with primary operable HER2-positive, HER2-enriched/ERBB2-high breast cancer according to PAM50 intrinsic

  • 0 views
  • 08 Apr, 2021
  • 1 location
A Study of H3B-6545 in Combination With Palbociclib in Women With Advanced or Metastatic Estrogen Receptor-Positive Human Epidermal Growth Factor Receptor-2 (HER2)-Negative Breast Cancer

The primary objective of this study is to evaluate the safety and tolerability of H3B-6545 and palbociclib when administered in combination in order to determine the maximum tolerated dose (MTD) and/or the recommended Phase 2 dose (RP2D) of this combination in women with advanced or metastatic estrogen receptor-positive (ER+) HER2- …

stage iv breast cancer
erbb2
breast cancer
growth factor
palbociclib
  • 12 views
  • 28 Mar, 2021
  • 10 locations
Anti-HER2 Therapy in Patients of HER2 Positive Metastatic Carcinoma of Digestive System

To seek the efficacy signals of trastuzumab in combination with chemotherapy in pretreated patients of HER2 positive, relapse or metastatic carcinoma of digestive system as response rate (RR) determined by the Investigator using RECIST 1.1, and provide evidence for phase III clinical trial.

digestive system tumor
trastuzumab
KRAS
squamous cell carcinoma
measurable disease
  • 7 views
  • 22 Jan, 2021
  • 1 location
A Study of BDTX-189 an Orally Available Allosteric ErbB Inhibitor in Patients With Advanced Solid Tumors.

2 (HER2/ErbB2) genes or epidermal growth factor receptor (EGFR/ErbB1). The main goals of this study are to: Find the recommended dose of BDTX-189 that can be given safely to

epidermal growth factor receptor
solid tumor
growth factor
measurable disease
HER2
  • 3 views
  • 04 Jun, 2021
  • 22 locations
Assessing the Immunogenicity of pING-hHER3FL

receptor (HER) family including: HER1 (also known as EGFR), HER2, HER3 and HER4 (also known as ErbB2, ErbB3, and ErbB4 respectively) is an important receptor family for the development of many malignancies

solid tumor
metastasis
metastatic solid tumor
hormone therapy
HER2
  • 0 views
  • 24 Jan, 2021
  • 1 location
Personalized Targeted IMMUNOtherapy-based Regimens in Recurrent GASTric Adenocarcinoma (IMMUNOGAST)

> Tumor positive for Epstein-Barr virus (EBV) (8%), which display recurrent PIK3CA mutations, extreme DNA hypermethylation, and amplification of JAK2, ErbB2, PD-L1 and PD-L2;

  • 0 views
  • 06 Apr, 2021
  • 8 locations
Neratinib and Paclitaxel With or Without Pertuzumab and Trastuzumab Before Combination Chemotherapy in Treating Patients With Metastatic or Locally Advanced Breast Cancer

This phase I/II trial studies the side effect and best dose of neratinib and to see how well it works with paclitaxel and with or without pertuzumab and trastuzumab before combination chemotherapy in treating patients with breast cancer that has spread to other places in the body (metastatic). Neratinib may …

trastuzumab
tumor cells
doxorubicin
locally advanced breast cancer
neutrophil count
  • 12 views
  • 28 Mar, 2021
  • 2 locations