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Found 43 clinical trials
Induction FLOT With CROSS CRT for Esophageal Cancer

This study evaluates a novel regimen of induction chemotherapy using a combination of docetaxel, oxaliplatin, and leucovorin, with short term infusional 5-FU (FLOT), given prior to chemoradiotherapy with concurrent carboplatin and paclitaxel, as neoadjuvant therapy prior to definitive surgical resection for patients with adenocarcinoma of the esophagus or gastroesophageal junction

cancer
progestogen
esophageal cancer
oophorectomy
carboplatin
  • 0 views
  • 17 Mar, 2022
  • 3 locations
Efficacy and Safety of Adjuvant Docetaxel and Trastuzumab in Stage I HER2-positive Breast Cancer

Among women with stage I HER2-positive breast cancer, adjuvant weekly paclitaxel plus trastuzumab (PH, qw×12) is one of the standard therapies. However, it is quite inconvenient for patients to received weekly treatment for 12 weeks, which also increased the patients' and social economic burdens. In our study, a prospective, randomized, …

  • 0 views
  • 24 Mar, 2022
  • 1 location
Preoperative Chemotherapy vs. Chemoradiation in Esophageal / GEJ Adenocarcinoma

The best treatment for resectable esophageal or gastroesophageal adenocarcinoma is unknown. Although an operation to remove the esophagus is the most common treatment, previous studies have shown that patients live longer when either perioperative (before and after surgery) chemotherapy or preoperative (before surgery) chemotherapy plus radiation is given, compared to …

cancer
esophageal cancer
esophagus cancer
carboplatin
capecitabine
  • 9 views
  • 10 Apr, 2021
  • 3 locations
Perioperative FLOT vs Adjuvant XELOX for CA Stomach

This is a single centre randomised controlled trial, comparing perioperative FLOT versus adjuvant XELOX for locally advanced gastric and esophagogastric junction cancers. Patients with operable clinical T3 or above and N1 or above gastric and esophagastric junction cancer would be recruited. Participants would be randomised to perioperative FLOT versus adjuvant …

  • 0 views
  • 13 Apr, 2022
  • 1 location
Hotspot TCR-T: A Phase I/Ib Study of Adoptively Transferred T-cell Receptor Gene-engineered T Cells (TCR-T)

This is a phase I/Ib study of adoptively transferred T-cell receptor gene-engineered T cells (TCR-T) targeting tumor-specific antigens, with in vivo CD40 activation and PD-1 blockade, for patients with incurable cancers. The study design is a safety lead-in TCR-T with CD40/PD-1 (3+3), followed by Simon's Two-Stage expansion design, 80% power …

  • 0 views
  • 13 Mar, 2022
  • 1 location
Docetaxel-based Chemoradiotherapy Plus Periradiation Chemotherapy Compared With INT 0116 Adjuvant Arm in Gastric Cancer

Although the intergroup 0116 trial was the first to demonstrate that adjuvant chemoradiotherapy offers a significant survival benefit in completely resected gastric cancer,it is more toxic and less effective. It is reasonable to optimize this regimen.

docetaxel
leucovorin
immunostimulants
fluorouracil
adenocarcinoma
  • 3 views
  • 25 Jan, 2021
  • 1 location
Effect of Oxygen Inhalation on Fatigue After Chemotherapy of Breast Cancer in High Altitude Area

At present, there are few studies on the side effects of chemotherapy in breast cancer patients at high altitude area, and there are no studies on the relationship between oxygen inhalation and fatigue after chemotherapy in breast cancer patients at high altitude. The investigators intend to explore whether oxygen inhalation …

cish
adjuvant chemotherapy
Accepts healthy volunteers
advanced breast cancer
growth factor
  • 0 views
  • 06 Nov, 2021
  • 1 location
TACE Sorafenib and PD-1 Monoclonal Antibody in the Treatment of HCC

Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-related death that ranks sixth in terms of incident cases, with an overall 5 years survival of 18%. Despite a significant improvement in treatment strategy, the overall survival of HCC remains low due to high recurrence, progressive liver dysfunction and …

measurable disease
hepatocellular carcinoma
measurable lesion
carcinoma
cancer
  • 0 views
  • 26 Jan, 2021
  • 1 location
Trial of Infusional FOLFIRINOX in First Line Treatment of Advanced Biliary Tract Cancers (FBI-TRAC)

This study is to evaluate the response rate and toxicity profile of infusional 5 fluorouracil, leucovorin, oxaliplatin and irinotecan (FOLFIRINOX) in first-line treatment of advanced biliary tract cancers and also to assess progression free survival and overall survival of FOLFIRINOX in first line treatment of advanced biliary tract cancers

measurable disease
leucovorin
biliary cancer
oxaliplatin
irinotecan
  • 5 views
  • 25 Feb, 2022
  • 1 location
Evaluation of the Relationship of TOP2 Expression and Effect of Non Dose-dense Chemotherapy for Breast Cancer

This is a prospectivemulticenternon-comparative interventional case series. 800 breast cancer patients who have already received chemotherapy prior to this study will be enrolled in the group, including 400 patients received the anthracyclines followed taxanes chemotherapy, and the other 400 patients who have received regiments containing no taxanes. Three tumor tissue …

ki-67
invasive breast cancer
anthracyclines
aromatase inhibitor
taxane
  • 0 views
  • 21 Jan, 2021
  • 1 location