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Found 76 clinical trials
A Pragmatic Study to Investigate the Efficacy and Safety of Mepolizumab in Severe Uncontrolled Asthma in Brazil

The anti-interleukin-5 monoclonal antibody mepolizumab is approved as an add-on therapy in Europe, Canada, USA, and other countries, to standard of care for the treatment of patients with severe eosinophilic asthma. Mepolizumab has been shown to reduce exacerbation rates and dependency on oral corticosteroid use in clinical trials in patients …

  • 0 views
  • 23 Jan, 2021
  • 2 locations
A Food Additive Removal Diet for Pediatric Eosinophilic Esophagitis

Prospective, pragmatic standard of care clinical trial comparing dietary therapies of standard dairy elimination diet alone (DED) to dairy elimination plus food additive elimination (FREE)

eosinophilia
elimination diet
  • 5 views
  • 25 Jan, 2021
  • 4 locations
Sponge and Eosinophil Peroxidase (EPO) Staining

Are we able to use the EPO staining technique using the sponge ?

elimination diet
  • 0 views
  • 15 May, 2021
  • 1 location
EoE Food Desensitization

This is a single-center, prospective, pilot clinical trial in which children ages 3-17 years with eosinophilic esophagitis (EoE) who have a known food that triggers EoE flares receive oral desensitization with that specific food antigen, followed by reintroduction of that food into the diet. The purpose of this study is …

  • 5 views
  • 05 Jul, 2021
  • 1 location
Ketotifen for Children With Functional Dyspepsia in Association With Duodenal Eosinophilia

gastroenteritis. Additionally, previous studies show mucosal eosinophilia is highly correlated with functional dyspepsia. Our usual current treatment pathway for functional dyspepsia in association with duodenal

abdominal pain
mast cell stabilizers
montelukast
mast cells
endoscopy
  • 14 views
  • 25 Jan, 2021
  • 1 location
Efficacy of Reslizumab Dose Escalation in Patients With Severe Asthma

Dose escalation of reslizumab can ameliorate sputum eosinophilia in severe asthmatics who have persistent sputum eosinophilia despite treatment with reslizumab at the standard dose.

  • 0 views
  • 17 Feb, 2021
  • 1 location
Benralizumab in Patients With Inadequate Response to Anti-IL5 Monoclonal Antibody Therapies

In severe prednisone-dependent eosinophilic asthma, Benralizumab would suppress airway eosinophilia that is not suppressed by either Mepolizumab or Reslizumab and this would be associated with

  • 22 views
  • 18 Sep, 2021
  • 1 location
Pilot Study of Reduced-Intensity Hematopoietic Stem Cell Transplant of DOCK8 Deficiency

Background -DOCK8 deficiency is a genetic disorder that affects the immune system and can lead to severe recurrent infections and possible death from infections or certain types of cancers, including blood cancers. A stem cell transplant is a life-saving treatment for this condition. In this study we are evaluating the …

  • 1 views
  • 24 Sep, 2021
  • 1 location
Dupilumab for Prevention of Recurrence of CRSwNP After ESS

The investigators believe that administering Dupilumab during the pre- and peri-operative period of surgery for chronic rhinosinusitis with nasal polyps (CRSwNP) will safely downregulate Type 2 inflammation of the healing sinus environment and will allow for better coordinated and more effective mucosal healing. Specifically, the investigators believe that endoscopic signs …

  • 0 views
  • 13 Jun, 2021
  • 1 location
Mepolizumab in Episodic Angioedema With Eosinophilia

Background Gleich syndrome is also called episodic angioedema with eosinophilia (EAE). People with EAE have episodes of swelling. They may also have itching, hives

myalgias
asthma
swelling
corticosteroids
angioedema
  • 0 views
  • 31 May, 2021
  • 1 location