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Found 17 clinical trials
Landmark vs. Ultrasound-Assisted Bone Marrow Biopsy Procedure Study (LUMP)

Bone marrow biopsies are routinely performed by the Medicine Bedside Procedure Team service at Froedtert Hospital. Typical indications for inpatient bone marrow biopsies include evaluations for cytopenia, leukemia, lymphoma, myelodysplastic syndrome, or plasma cell dyscrasia. The bone marrow is sampled from the posterior iliac crest, ideally by drilling into the …

  • 02 Jun, 2022
  • 1 location
3D Printed Scaffold Device for Ridge Preservation After Tooth Extraction

Following tooth extraction, the socket heals naturally with bone in 1 to 2 months. This healing process occurs with substantial reduction of the original height and width of the alveolar ridge. In a significantly resorbed ridge, bone augmentation procedures are necessary before dental implant placement. Autogenous bone is the gold …

Accepts healthy volunteers
  • 01 May, 2022
  • 1 location
Ridge Preservation Comparing the Clinical and Histologic Healing of Two Different Putty Bone Grafts

The primary aims of this study are to compare, after 4 months, the clinical and histologic results of a combination demineralized/mineralized putty allograft vs. synthetic calcium phosphosilicate (CPS) putty alloplast graft utilization in socket preservation procedures. A regenerative tissue matrix membrane will be used to cover each graft lying below …

Accepts healthy volunteers
  • 21 Oct, 2022
  • 1 location
Clinical vAlidation of a MobilE appLication ("ProRodinki") in the Assessment of the maLignant skIn neoplAsms (CAMELLIA)

A Multicenter, Prospective, Low-interventional Clinical Study Evaluating on mobile application validation ("ProRodinki") in assessing the risk of skin malignant neoplasms

skin lesion
skin tumor
  • 14 Jun, 2022
  • 2 locations
Sotorasib in KRAS G12C Mutated, Resectable, Stage Ib-IIIA NSCLC

This is a single arm study, conducted at two centers, of neoadjuvant sotorasib in treatment naïve patients with stage Ib-IIIa NSCLC. The study will accrue 25 patients in all. Patients must have been deemed surgically resectable and physiologically fit for surgery by a thoracic surgeon prior to enrollment.

measurable disease
neutrophil count
  • 04 Oct, 2022
  • 1 location
Abemaciclib in Treating Patients With Surgically Resectable, Chemotherapy Resistant, Triple Negative Breast Cancer

This phase II trial studies how well abemaciclib works in treating patients with triple negative breast cancer that can be removed by surgery (resectable) and does not respond to treatment with chemotherapy. Abemaciclib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.

estrogen receptor
lobular carcinoma
  • 15 Jul, 2022
  • 3 locations
Breaking Innate PD-1 Inhibitor (PD1i) Resistance Using Epigenetic Modifiers; Antitumor Efficacy and Correlative Analyses of Entinostat Plus Pembrolizumab in Non-Inflamed Metastatic Melanoma (MM)

Cancers develop in two different ways. First, cancer cells can become invisible to the immune system by stop having proteins on their surface that are required for the immune system to recognize them. In this scenario, tumors do not attract any immune cells (e.g. white blood cells) whatsoever or they …

tumor cells
melanoma skin
malignant melanoma of skin
  • 14 Oct, 2022
  • 1 location
Ridge Preservation Using Xenogenic Bone Graft and Pre-hydrated Collagen Membrane

This pilot multicentric randomized controlled clinical trial is aimed at evaluating the composition of the new-formed tissue into the dental socket after 6 months from tooth extraction and the application of a combination of xenograft bone granules and collagen membrane. Extraction sites will be either grafted with Dentsply Symbios Xenograft …

  • 15 Aug, 2021
  • 5 locations
Inflammatory Marker and Pre-existing Venous Fibrosis to Predict AVF Mal-maturation

End-stage renal disease patients needs a functional vascular access to receive hemodialysis and prolong their lives. Arteriovenous fistula (AVF) is priority consideration for hemodialysis, which is a connecting a superficial vein to a nearby artery and allowing this vein to enlarge and increase in internal diameter under arterial circulation. Unfortunately, …

  • 16 Jun, 2022
  • 1 location
Micophenolate Mofetil Versus Azathioprine in Myocarditis

The study is aimed at studying the direct efficacy of mycophenolate mofetil (mycophenolate mofetil, CellCept, Genentech, N015393/02, 12.08.2009) (in combination with corticosteroids (methylprednisolone, Metypred, Orion, 003467, 26.02.2016)) in the treatment of lymphocytic myocarditis: the effect on symptoms, structural and functional parameters of the heart, on the outcomes of lymphocytic myocarditis: …

chronic heart failure
enzyme inhibitors
heart disease
beta blockers
  • 24 Mar, 2022
  • 1 location