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Found 29 clinical trials
Sildenafil for Liver Fibrosis in Adolescents and Adults After Fontan Operation

Fontan operation is currently the most common procedure performed in patients with single-ventricle physiology. This surgery allows for passive caval blood flow to the pulmonary arteries in the absence of a subpulmonary pump and therefore separating the pulmonary circulation from systemic circulation. However, late hepatic complications such as liver fibrosis, …

venous pressure
liver disease
  • 14 Jun, 2022
  • 1 location
Characterizing Humoral Immune Response to Mosquito Bites

The characteristics of the humoral response directed against mosquito saliva antigens are not known precisely. This is a major limitation for using immunological markers as an outcome in epidemiological trials and as an indicator for operational deployment of interventions. Recent advances in the assembly of the genome of some Anopheles …

  • 22 Aug, 2021
  • 1 location
Application of Magnesium-rich Artificial Cerebrospinal Fluid in Subarachnoid Hemorrhage

Intracerebral hemorrhage (ICH) is one of the common fatal types of cerebral apoplexy with high mortality and disability rates. Hematoma volume and complications of intracerebral hemorrhage are major predictors of early death and poor prognosis. The hematoma and its metabolites are key therapeutic targets. At present, in order to improve …

intracerebral hemorrhage
  • 30 Jun, 2022
  • 1 location
Shingrix Vaccine in Patients With Moderate to Severe Ulcerative Colitis on Tofacitinib

Patients with ulcerative colitis (UC), a chronic inflammatory bowel disease (IBD), have been shown to be at increased risk of developing certain infections, such as shingles from the Herpes Zoster (HZ) virus, as a result of their underlying disease. Patients with UC are also often treated with immunosuppressants, and research …

ulcerative colitis
  • 09 Sep, 2023
  • 1 location
Human Immune Response to Ixodes Scapularis Tick Bites

Background Each year, the number of cases of tick-borne diseases increases. The deer tick (Ixodes scapularis) is the vector of at least 7 pathogens that cause human diseases, including Lyme disease. Researchers want to learn more to help them develop vaccines against ticks in the future. Objective To learn how …

blood draw
tick-borne diseases
Accepts healthy volunteers
tick bite
skin biopsy
  • 30 Aug, 2023
  • 1 location
Anti-CD38 Antibody Treating APS With Thrombocytopenia

To evaluate the safety and efficacy of anti-CD38 antibody in the treatment of antiphospholipid syndrome with secondary thrombocytopenia in patients who have not responded adequately or relapsed after first-line treatment and at least one second-line therapy including rituximab and/or TPO-RA.

  • 22 Aug, 2023
  • 1 location
Comparing a Novel Point-of-care Cytokine Biomarker Lateral Flow Test With Nucleic Acid Amplification Tests for Detection of Sexually Transmitted Infections and Bacterial Vaginosis (GIFT)

To evaluate the performance of a lateral flow POC test, namely the Genital InFlammation Test (GIFT), for identifying women with inflammatory STIs and BV, who are at higher risk of HIV infection and reproductive complications; To evaluate how the GIFT device can be integrated in a feasible, acceptable, and cost-effective …

  • 30 Jul, 2023
  • 1 location
Cardiac Magnetic Resonance Imaging (MRI) Normal Reference Control Group Testing

The purpose of this research is to understand how to apply cardiac magnetic resonance imaging (CMR) to women with small artery heart disease by looking at the CMRs of women without heart disease. The investigators will study 40 women with no heart disease to learn more about the usefulness of …

Accepts healthy volunteers
  • 09 Sep, 2023
  • 1 location
Genetics of Obesity in Chinese Youngs

The purpose of this study is to explore the pathogenesis and genetic susceptibility of obese subjects,providing a convincing argument for further treatment of obesity and metabolic syndrome.

body mass index
metabolic syndrome
  • 02 May, 2021
  • 1 location
Development of a Serum and Cellular Biomarkers Cluster for the Assessment of Degenerative Aortic Valve Stenosis Progression. (AthenaValve)

evaluation of the early stages, in order to develop and validate a multiplexed Enzyme-linked Immunosorbent Assay kit (multiplex ELISA). Advanced bioinformatics analysis will facilitate the selection of the

aortic valve stenosis
ct scan
  • 22 Oct, 2022
  • 2 locations