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Found 1716 clinical trials
A Study Evaluating the Efficacy and Safety of Oral Etrasimod in the Treatment of Adult Participants With Moderately to Severely Active Crohn's Disease (CULTIVATE)

This is a Phase 2/3 study that comprises 5 substudies designed to evaluate the efficacy, safety, and tolerability of oral etrasimod as therapy in adult participants with moderately to severely active Crohn's disease (CD) who are refractory or intolerant to at least 1 of the current therapies for CD (ie, …

certolizumab pegol
vedolizumab
ustekinumab
prednisone
immunosuppressive agents
  • 207 views
  • 26 Jul, 2022
  • 314 locations
A Long-term Extension Study of Mirikizumab (LY3074828) in Participants With Crohn's Disease (VIVID-2)

The reason for this study is to determine the long-term efficacy and safety of the study drug mirikizumab in participants with Crohn's disease.

crohn's disease
  • 47 views
  • 25 Jul, 2022
  • 269 locations
Induction Study #1 of Oral Ozanimod as Induction Therapy for Moderately to Severely Active Crohn's Disease

This is a study to explore the effect of oral ozanimod as an induction treatment for participants with moderately to severely active Crohn's Disease.

crohn's disease
abdominal pain
corticosteroids
immunomodulators
endoscopy
  • 918 views
  • 26 Jul, 2022
  • 358 locations
Study Comparing Intravenous (IV)/Subcutaneous (SC) Risankizumab to IV/SC Ustekinumab to Assess Change in Crohn's Disease Activity Index (CDAI) in Adult Participants With Moderate to Severe Crohn's Disease (CD)

Crohn's disease (CD) is a long-lasting condition causing inflammation that can affect any part of the gut. This study will evaluate how well risankizumab works compared to ustekinumab. This study will assess change in Crohn's Disease Activity Index (CDAI). Risankizumab is an investigational drug being developed for the treatment of …

tumour necrosis
risankizumab
abdominal pain
ustekinumab
crohn's disease
  • 422 views
  • 28 Jul, 2022
  • 276 locations
An Extension Study of Oral Ozanimod for Moderately to Severely Active Crohn's Disease

This is an extension study to evaluate safety and efficacy of ozanimod in participants with moderately to severely active Crohn's Disease.

crohn's disease
remission
  • 1128 views
  • 28 Jul, 2022
  • 480 locations
An Active and Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Crohn's Disease (INTREPID)

This study seeks to evaluate the safety and efficacy of brazikumab versus placebo (Stage I) and versus an active comparator (Stage 2) in participants with moderately to severely active CD and will include assessments of clinical response as demonstrated by improvement of symptoms and colonic mucosal appearance as observed on …

prednisone
conventional treatment
immunomodulators
endoscopy
mercaptopurine
  • 550 views
  • 20 Jul, 2022
  • 67 locations
A Long-term Extension Study of Ustekinumab in Pediatric Participants (UNITED)

The purpose of this study is to collect long-term safety data of subcutaneous (SC) ustekinumab

ustekinumab
remission
  • 0 views
  • 07 Jul, 2022
  • 7 locations
Stopping Aminosalicylate Therapy in Inactive Crohn's Disease (STATIC)

The purpose of this study is to assess whether withdrawal of aminosalicylate (5-ASA) is non-inferior to continuation of 5-ASA therapy in Crohn's disease (CD) subjects in remission.

mesalamine
aminosalicylate
crohn's disease
remission
  • 146 views
  • 04 Mar, 2022
  • 28 locations
A Study of Darvadstrocel in Adults With Crohn's Disease and Complex Perianal Fistula (EMPIRE)

The main aim is to check the long term side effects of a repeat treatment of darvadstrocel and to see if that treatment improves symptoms of Crohn's disease and complex perianal fistula. Participants will attend 8 clinic visits and will receive 1 treatment of darvadstrocel at the third visit. A …

crohn's disease
remission
  • 0 views
  • 06 Mar, 2022
  • 27 locations
An Investigational Study of Experimental Medication BMS-986165 in Participants With Moderate to Severe Crohn's Disease

The purpose of this study is to assess the safety and effectiveness of BMS-986165 compared to placebo in participants with moderately to severely active Crohn's Disease.

enteropathy
crohn's disease
  • 372 views
  • 11 Jul, 2022
  • 216 locations