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Found 1719 clinical trials
A Phase 2a Safety and Efficacy Open-Label Study of PRA023 in Subjects With Moderately to Severely Active Crohn's Disease (APOLLO-CD)

The purpose of this study is to assess the safety and efficacy of PRA023 in participants with moderately to severely active Crohn's Disease. After the completion of the 12-week induction period, all participants have the option to continue in the open-label extension for another 38 weeks.

tumour necrosis
crohn's disease
endoscopy
tumor necrosis factor
  • 0 views
  • 05 Jun, 2022
  • 31 locations
A Study to Test Whether BI 706321 Combined With Ustekinumab Helps People With Crohn's Disease

This study is open to adults, aged 18-75 years, with moderate to severe Crohn's disease. The purpose of this study is to find out whether BI 706321 combined with ustekinumab helps people with Crohn's disease. BI 706321 is a medicine being developed to treat Crohn's disease. Ustekinumab is a medicine …

faecal calprotectin
ustekinumab
crohn's disease
tumor necrosis factor
methotrexate
  • 1 views
  • 29 Jun, 2022
  • 30 locations
A Study to Evaluate the Long-term Safety and Efficacy of Deucravacitinib in Participants With Crohn's Disease or Ulcerative Colitis

The purpose of this study is to evaluate the long-term safety and efficacy of Deucravacitinib in participants who have previously been enrolled in a Deucravacitinib Phase 2 study for moderate to severe Crohn's disease or moderate to severe Ulcerative Colitis.

crohn's disease
colitis
ulcerative colitis
ulceration
  • 0 views
  • 15 May, 2022
  • 15 locations
Study to Assess Efficacy and Safety of Cx601 Adult Allogeneic Expanded Adipose-derived Stem Cells (eASC) for the Treatment of Complex Perianal Fistula(s) in Participants With Crohn's Disease (CD)

The purpose of this study is to evaluate the combined remission of complex perianal fistulas, defined as the clinical assessment at Week 24 of closure of all treated external openings that were draining at baseline despite gentle finger compression, and absence of collections greater than (>) 2 centimeter (cm) (in …

remission
immunosuppressive agents
monoclonal antibodies
certolizumab pegol
crohn's disease
  • 230 views
  • 02 Dec, 2021
  • 178 locations
Study of the Kono-S Anastomosis Versus the Side-to-side Functional End Anastomosis

This study proposes a randomized prospective study comparing the Kono-S anastomosis to the standard side-to-side anastomosis.This will be a multi-center randomized prospective trial. Patients with Crohn's ileitis or Crohn's ileocolitis requiring resection will be randomized to undergo either the Kono-S anastomosis or the side-to-side functional end anastomosis.

ileocolitis
tumor necrosis factor alpha
tumour necrosis
tumor necrosis factor
ileitis
  • 14 views
  • 14 Apr, 2022
  • 12 locations
Ileal Crohn's Disease and Post-operative Outcome: Prospective Cohort Study of the REMIND Group (POP-REMIND)

Crohn's disease (CD), a chronic inflammatory process in intestinal segments leads to tissue damage. More than two thirds of CD patients need intestinal resection. Symptomatic clinical recurrence occurs in 60% by 10 years. The principal factors affecting postoperative recurrence are active smoking, penetrating disease, perianal lesions history, prior intestinal resection, …

luminal
crohn's disease
tumor necrosis factor
bowel resection
microbiota
  • 9 views
  • 27 Feb, 2022
  • 12 locations
An Extension Study of Oral Ozanimod for Moderately to Severely Active Crohn's Disease

This is an extension study to evaluate safety and efficacy of ozanimod in participants with moderately to severely active Crohn's Disease.

remission
crohn's disease
  • 1128 views
  • 28 Feb, 2022
  • 509 locations
A Study of E6011 in Participants With Active Crohn's Disease

The primary purpose of this study is to examine the efficacy and safety of E6011 at 12 weeks after administration by means of double-blind placebo-controlled trial.

corticosteroids
small intestine
ciprofloxacin
crohn's disease
methotrexate
  • 35 views
  • 25 Mar, 2022
  • 45 locations
A Study of Darvadstrocel for Treating Complex Perianal Fistulas in Children and Teenagers With Crohn's Disease

A perianal fistula is an abnormal passageway that develops between the rectum and the skin near the anus. The fistula is considered complex if it branches into several openings or an abscess is also present. The main aim of this study is to learn if complex perianal fistulas in children …

luminal
monoclonal antibodies
crohn's disease
methotrexate
ulceration
  • 0 views
  • 27 Oct, 2021
  • 23 locations
A Study of TAK-018 in Preventing the Recurrence of Crohn's Disease After Surgery

The main aim is to see if TAK-018 reduces the recurrence of intestinal inflammation after abdominal resection surgery in adults with Crohn's disease. Participants will take either TAK-018 or placebo tablets by mouth, 2 times each day for up to 26 weeks after surgery. The placebo looks like TAK-018 but …

crohn's disease
tumor necrosis factor
tumor necrosis factor alpha
immunomodulators
antibiotic therapy
  • 67 views
  • 03 May, 2022
  • 41 locations