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Found 1727 clinical trials
Prebiotics and Diet to Reduce "Leaky" Gut in First Degree Relatives of Crohn's Disease Patients

Crohn's disease (CD) is a recurring inflammation of the intestines. The etiology is unknown; however evidence suggests that it could be a combination of gut microbes, environmental factors and genetics. CD has a strong genetic component, with up to 12% of patients having familial history. The Western diet is also …

  • 0 views
  • 04 May, 2022
  • 1 location
Double/Single Balloon Enteroscopy Stiffening Wire RCT

This is a randomized clinical trial examining the use of a stiffening wire to increase depth of maximal insertion during double and single balloon enteroscopy.

  • 1 views
  • 23 Feb, 2022
  • 1 location
Specialty Medical Homes to Improve Outcomes for Patients With IBD and Behavioral Health Conditions

A comparative effectiveness study using an individual-level randomized design along with a pragmatic, mixed-methods approach to compare two strategies (e.g. in-person supported care, technology-supported care) all of which include evidence-based components for delivering IBD and BH care. Quantitative (e.g. self-report, electronic health record, process) and qualitative (e.g., interviews) data will …

enteropathy
ulcerative colitis
ulceration
colitis
crohn's disease
  • 0 views
  • 12 Feb, 2022
  • 1 location
Visceral Sensitivity in IBD (Irritable Bowel Disease) and IBS (Irritable Bowel Syndrome)

Aim More insight in pathogenesis of IBS and IBD. Samples are collected in context of an European research project.

bowel dysfunction
crohn's disease
colitis
ulcerative colitis
  • 39 views
  • 21 Jan, 2021
The Nordic IBD Treatment Strategy Trial (NORDTREAT)

Purpose To demonstrate that personalised therapy can be delivered to patients with IBD, by treating patients with an increased risk of poor disease course, defined by a serum protein signature at diagnosis, with a top-down treatment, and that this treatment strategy improves clinical outcomes. Objectives Primary objective: To assess if …

ulcerative colitis
immunomodulators
endoscopy
colitis
abdominal pain
  • 0 views
  • 30 Apr, 2022
  • 9 locations
ENhanced Recovery in CHildren Undergoing Surgery (ENRICH-US)

The institution of perioperative Enhanced Recovery Protocols (ERPs) has been found to decrease hospital length of stay, in-hospital costs, and complications among adult surgical populations but data in pediatric populations are lacking. The Assessing Effectiveness and Implementation of a Perioperative Enhanced Recovery Protocol for Children Undergoing Gastrointestinal Surgery, which has …

Accepts healthy volunteers
abdominal surgery
enteropathy
inflammatory bowel disease
ulcerative colitis
  • 0 views
  • 12 May, 2022
  • 1 location
Effect of Ileocolonic Delivered Vitamins and an Anti-Inflammatory Diet on Crohn's Disease and Healthy Volunteers

This study will evaluate if the Groningen Anti-Inflammatory Diet and the ileocolonic delivery of vitamin B2, B3 and C can positively influence the course of Crohn's disease and can positively alter the gut microbiome of Crohn's disease patients as well as healthy volunteers.

Accepts healthy volunteers
vitamin
mucosal inflammation
faecal calprotectin
crohn's disease
  • 0 views
  • 04 Nov, 2021
  • 1 location
Efficacy, Immunogenicity and Safety of S. Flexneriza-S. Sonnei Bivalent Conjugate Vaccine in Volunteers Aged From 6 Months to 5 Years

The purpose of this study is to evaluate the efficacy, immunogenicity and safety of S. Flexneriza-S. Sonnei Bivalent Conjugate Vaccine in infants and children aged from 6 months to 5 years.

Accepts healthy volunteers
vaccination
glycan
  • 0 views
  • 24 Mar, 2022
  • 2 locations
A Study to Evaluate Adverse Events and Change in Disease Activity in Participants Between 18 to 75 Years of Age Treated With Intravenous (IV) Infusion and Subcutaneous (SC) Injections of ABBV-154 for Moderately to Severely Active Crohn's Disease (AIM-CD)

Crohn's disease (CD) is a long-lasting condition causing inflammation that can affect any part of the gut. CD may cause tiredness, loose stools with or without bleeding, abdominal pain, weight loss, and fever. This study evaluates how safe and effective ABBV-154 is in participants treated for moderately to severely active …

certolizumab pegol
mucosal inflammation
ileal disease
natalizumab
infliximab
  • 4 views
  • 09 Jun, 2022
  • 68 locations
A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Crohn's Disease (CD)

Vedolizumab is a medicine that helps to reduce inflammation and pain in the digestive system. In this study, children and teenagers with moderate to severe Crohn's disease will be treated with vedolizumab. The main aim of the study is to check if participants achieve remission after treatment with the vedolizumab. …

  • 0 views
  • 13 Jun, 2022
  • 40 locations