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Found 10 clinical trials
Pharmacokinetics of Cobitolimod Enemas in Participants With Active Ulcerative Colitis

The purpose of the study is to evaluate the PK, safety and tolerability of cobitolimod ememas (500mg/50mL) given to participants with active left-sided UC.

endoscopy
enemas
hematochezia
  • 0 views
  • 29 Jun, 2022
  • 1 location
Understanding Mechanisms of Normal and Disordered Defecation

Researchers are trying to better understand why constipation occurs and improve the tests for diagnosing these conditions.

chronic constipation
Accepts healthy volunteers
evacuations
  • 92 views
  • 27 Feb, 2022
  • 1 location
Endoscopically-delivered Purastat to Treat Bleeding Caused by Radiation Proctopathy

30,000 people in the UK are treated with pelvic radiotherapy each year. Rectal bleeding is a common symptom side effect caused by radiation proctopathy (RP). RP is due to the effect of radiation on the rectum (back passage) which causes poor blood supply (ischaemia) which leads to stiffness/scarring (fibrosis) and …

  • 4 views
  • 29 Sep, 2021
  • 1 location
A Study of Niclosamide Enemas in Subjects With Active Ulcerative Proctitis or Ulcerative Proctosigmoiditis

This will be a phase I/IIa, open-label, three-stage, single center study aimed at investigating the safety, the efficacy (clinical and endoscopic effects) and the pharmacokinetics of Niclosamide enema 150 mg/60 ml and 450 mg/60 ml in subjects with mild-to-moderate UP and UPS, defined as a Modified Mayo Score (MMS) ≥ …

endoscopy
proctitis
enemas
hematochezia
  • 67 views
  • 07 Jun, 2022
  • 1 location
Faecal Microbiota Transplantation in Irritable Bowel Syndrome (MISCEAT)

Irritable bowel syndrome (IBS) is the most common functional bowel disorder, being present in approximately 10% of adult Europoid population. The etiology of IBS is elusive. Literature indicates that modification of patients´colonic microbiota might ameliorate the condition. Here we test an intervention by faecal microbiota transplantation of artificially inflated microbiome …

  • 0 views
  • 19 Jun, 2022
  • 1 location
PediCRaFT: Pediatric Crohn's Disease Fecal Transplant Trial (PediCRaFT)

The objective of this study is to assess the feasibility of a novel colonic and oral fecal microbiota transplantation protocol for the treatment of active pediatric Crohn's disease (CD). Specifically, we will test the hypothesis that a protocol of combination fecal microbiota colonoscopic infusion and oral microbiota capsules (OMC), using …

fecal microbiota transplantation
enteropathy
inflammatory bowel disease
microbiota
pediatric onset crohn's disease
  • 114 views
  • 14 May, 2022
  • 2 locations
Outcomes and Data Collection for Fecal Microbiota Transplantation for the Treatment of Recurrent Clostridium Difficile

The purpose of this study is to see if stool transplant performed by colonoscopy is effective at treating recurrent Clostridium difficile (C. diff) infection of the colon. During the procedure a stool sample is taken from a healthy donor (usually family member or close friend) and transplanted directly into the …

oral metronidazole
fecal microbiota transplantation
vancomycin
microbiota
antibiotics
  • 0 views
  • 04 Mar, 2022
  • 1 location
STOPS Trial: Total vs Subtotal Colectomy for Slow Transit Constipation

Total colectomy with ileorectal anastomosis is a traditional surgical option for slow transit constipation. Subtotal colectomy with caecorectal anastomosis is suggested to be a superior approach. However, the optimal surgical option for slow transit constipation (STC) is controversial.

  • 0 views
  • 16 May, 2022
  • 11 locations
Auto Fecal Microbial Transplant Post Helicobacter Pylori Antibiotic Therapy

Current guidelines mandate Helicobacter pylori (H. Pylori) eradication with 2-3 antibiotics for 14 days ,This may result in multiple side effects and in eradication of important bacterial species to human health, exposing humans to multiple disease conditions. Preservation of fecal microbiome prior to antibiotic therapy and auto-transplantation of the microbes …

  • 0 views
  • 04 May, 2022
  • 1 location
Defecation Function and Quality of Life in the Patients Treated With Surgery for Slow Transit Constipation

Although surgical options for slow transit constipation (STC) have been proven to be a definite treatment, improvements in the associated defecation function and quality of life are rarely studied. This study aims to investigate the effectiveness of total or subtotal colectomy, with respect to short- and long-term defecation function and …

  • 2 views
  • 14 May, 2022
  • 1 location