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Found 12 clinical trials
Fecal Microbiota Transplant (FMT) Plus Fidaxomicin for Severe or Fulminant Clostridium Difficile Infection

Fecal microbiota transplantation (FMT) has been very effective for patients who suffer from mild C diff infection (CDI) which recurs but it is unclear how effective FMT alone is in treating severe and fulminant CDI. Current evidence suggests that FMT in combination with vancomycin is required, and that multiple treatments …

  • 06 Oct, 2021
  • 1 location
Understanding Mechanisms of Normal and Disordered Defecation

Researchers are trying to better understand why constipation occurs and improve the tests for diagnosing these conditions.

chronic constipation
  • 20 Sep, 2021
  • 1 location
Endoscopically-delivered Purastat to Treat Bleeding Caused by Radiation Proctopathy

30,000 people in the UK are treated with pelvic radiotherapy each year. Rectal bleeding is a common symptom side effect caused by radiation proctopathy (RP). RP is due to the effect of radiation on the rectum (back passage) which causes poor blood supply (ischaemia) which leads to stiffness/scarring (fibrosis) and …

  • 29 Sep, 2021
  • 1 location
Distribution of FMT After Delivery by Lower GI Endoscopy vs Enema With and Without Positioning of the Patient

While delivery of an FMT-treatment to the cecum is visualized in a lower GI-endoscopy, it is uncertain whether delivery by enema distributes the FMT to the proximal segments of the colon. Positioning of the patient during the enema procedure may improve distribution to the proximal colon. Differences in distribution may …

  • 22 Nov, 2021
  • 1 location
Osteopathic Manipulative Treatments and Neurogenic Bowel Dysfunction in Patients With Spinal Cord Injuries.

in a lower quality of life caused by loss of independence, sense of embarrassment, mental disorder, social isolation. Conservative treatments for NBD after SCI include oral laxatives, enemas

spinal cord
spinal injury
bowel dysfunction
  • 04 Sep, 2021
  • 1 location
Laser Acupuncture Improves Constipation for Critical Care Nurses During the COVlD-19 Pandemic

medical staff is high, especially in acute and severe units. The reason is high work pressure. , Life tension and other characteristics. In western medicine, enemas or stool softening drugs are often used

  • 04 Sep, 2021
  • 1 location
Faecal Microbiota Transplantation in Irritable Bowel Syndrome

Irritable bowel syndrome (IBS) is the most common functional bowel disorder, being present in approximately 10% of adult Europoid population. The etiology of IBS is elusive. Literature indicates that modification of patientscolonic microbiota might ameliorate the condition. Here we test an intervention by faecal microbiota transplantation of artificially inflated microbiome …

  • 20 Oct, 2021
  • 1 location
PediCRaFT: Pediatric Crohn's Disease Fecal Transplant Trial

The objective of this study is to assess the feasibility of a novel colonic and oral fecal microbiota transplantation protocol for the treatment of active pediatric Crohn's disease (CD). Specifically, we will test the hypothesis that a protocol of combination fecal microbiota colonoscopic infusion and oral microbiota capsules (OMC), using …

inflammatory bowel disease
crohn's disease
investigational drug
clostridium difficile
  • 29 Mar, 2021
  • 1 location
Outcomes and Data Collection for Fecal Microbiota Transplantation for the Treatment of Recurrent Clostridium Difficile

The purpose of this study is to see if stool transplant performed by colonoscopy is effective at treating recurrent Clostridium difficile (C. diff) infection of the colon. During the procedure a stool sample is taken from a healthy donor (usually family member or close friend) and transplanted directly into the …

oral vancomycin
antibiotic therapy
clostridium difficile
oral metronidazole
  • 10 Oct, 2021
  • 1 location
Effects of Osteopathic Manipulative Treatment in People With Neurogenic Bowel Dysfunction

People affected central nervous system (CNS) diseases often suffer from neurogenic bowel dysfunction (NBD) that causes a reduction in the quality of life and participation in social life. Although some conservative approaches exist to treat NBD, none has shown to be effective in managing this complex condition. Osteopathic manipulative treatment …

  • 23 Jan, 2021
  • 1 location