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Found 19 clinical trials
Effect of Probiotic (VSL#3) on Gut Microbiome and Bacterial Translocation in Healthy Asian Volunteers

, their other mechanisms of action have not been systematically characterized. The ability of probiotics to modulate dysbiosis may lead to reduced levels of endotoxaemia and oxidative stress. In this

Accepts healthy volunteers
  • 27 Oct, 2021
  • 1 location
Omega-3 PUFA for Treatment of Patients With Idiopathic Oligoasthenoteratospermia

endotoxemia and a series of metabolic syndrome. N-3 polyunsaturated fatty acids may play an important role in regulating metabolism and physiological functions in the body. A clinical research found that both

  • 26 Sep, 2021
  • 1 location
Effect of Probiotics on Cardiometabolic Health

Atherosclerosis is a major risk factor for cardiovascular diseases. Recently, dysbiosis of gut microbiota has been reported to play an important role in the pathogenesis of atherosclerosis. Animal studies have demonstrated that administration of probiotics help delay the progression of atherosclerosis through several mechanisms. This trial aims to examine its …

Accepts healthy volunteers
  • 21 Jan, 2022
  • 2 locations
Effect of Parenteral Nutrition With n-3 PUFAs on Patients With Intestinal Failure

Randomized, double-blind, controlled clinical trial to evaluate the effect of parenteral nutrition (PN) supplemented with lipid emulsions containing 0.1-0.2 g omega 3 polyunsaturated fatty acids (n-3 PUFA)/kg body weight/day for 7 days on malondialdehyde (MDA) levels, a marker of lipoperoxidation of reactive species, compared with a control group (without n-3 …

  • 03 Sep, 2021
  • 2 locations
Effect of BCAA Supplementation on Muscle Mass Muscle Quality and Molecular Markers of Muscle Regeneration in CLD Patients

Loss of muscle mass (sarcopenia) is a major complication in a patient with cirrhosis, impacting the disease outcome, quality of life and survival. Cirrhotics lose muscle mass (MM) while waiting for liver transplant (LT) and even after LT, impacting the outcome of LT. Moreover, LT is elusive for majority of …

amino acid
liver transplant
  • 19 Feb, 2021
  • 1 location
Connection Between Periodontitis and Exudative Age-related Macular Degeneration

Aqueous flare is increased in different kind of inflammations of eye. This is caused by disruption of blood-aqueous-barrier. The investigators assume that low grade systemic inflammation, such as periodontitis, increase aqueous flare and possibly activates exudative age-related macular degeneration.

  • 26 Jan, 2021
  • 1 location
Effects of Non-calorie Sweeteners Mono- and Disaccharides on Intestinal Barrier Function

The aim of the present study is to determine the effect of non-nutritive sweeteners on intestinal barrier function and inflammatory markers in healthy subjects in comparison to mono- and disaccharides.

  • 19 Mar, 2021
  • 1 location
Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized Open-Label Study

Prospective, multicenter, randomized, open-label study of standard of care plus the PMX cartridge versus standard of care alone in patients with endotoxemic septic shock

septic shock
positive pressure ventilation
fluid resuscitation
  • 21 Sep, 2021
  • 14 locations
Effect of Saturated Fat (Desi Ghee) on Gut-Liver Axis in Alcoholic Hepatitis

; oxidative stress, dysbiosis, intestinal hyperpermeability, and endotoxemia. Dietary fats not only improve nutritional status in ALD but specific properties of saturated fats (SF) have the potential to

liver disease
tight junction proteins
  • 18 Nov, 2021
  • 2 locations
Periodontal Therapy and Oral-gut-hepatic Axis Cirrhosis: a Randomized Controlled Trial

, periodontal diseases, endodontic lesions, dry socket, halitosis, and odontogenic infections. Bajaj et al have demonstrated systematic periodontal therapy in cirrhotic outpatients improved endotoxemia

liver disease
Accepts healthy volunteers
hepatic failure
liver transplant
  • 06 Oct, 2021
  • 1 location