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Found 19 clinical trials
Effect of Probiotic on Gut Microbiome and Bacterial Translocation in Healthy Asian Volunteers

, their other mechanisms of action have not been systematically characterized. The ability of probiotics to modulate dysbiosis may lead to reduced levels of endotoxaemia and oxidative stress. In this

Accepts healthy volunteers
  • 0 views
  • 14 Apr, 2022
  • 1 location
Omega-3 PUFA for Treatment of Patients With Idiopathic Oligoasthenoteratospermia

endotoxemia and a series of metabolic syndrome. N-3 polyunsaturated fatty acids may play an important role in regulating metabolism and physiological functions in the body. A clinical research found that both

  • 45 views
  • 12 Feb, 2022
  • 1 location
Effect of Prebiotics on Hyperuricemia

Hyperuricemia is a major risk factor for many chronic diseases. Recently, dysbiosis of gut microbiota has been reported to play an important role in the pathogenesis of Hyperuricemia. Animal studies have demonstrated that administration of prebiotics help delay the progression of Hyperuricemia through several mechanisms. This trial aims to examine …

Accepts healthy volunteers
  • 0 views
  • 02 Jun, 2022
  • 2 locations
Effect of Parenteral Nutrition With n-3 PUFAs on Patients With Intestinal Failure

Randomized, double-blind, controlled clinical trial to evaluate the effect of parenteral nutrition (PN) supplemented with lipid emulsions containing 0.1-0.2 g omega 3 polyunsaturated fatty acids (n-3 PUFA)/kg body weight/day for 7 days on malondialdehyde (MDA) levels, a marker of lipoperoxidation of reactive species, compared with a control group (without n-3 …

  • 0 views
  • 27 Feb, 2022
  • 1 location
Prebiotics and Diet to Reduce "Leaky" Gut in First Degree Relatives of Crohn's Disease Patients

Crohn's disease (CD) is a recurring inflammation of the intestines. The etiology is unknown; however evidence suggests that it could be a combination of gut microbes, environmental factors and genetics. CD has a strong genetic component, with up to 12% of patients having familial history. The Western diet is also …

  • 0 views
  • 04 May, 2022
  • 1 location
Effects of Non-calorie Sweeteners Mono- and Disaccharides on Intestinal Barrier Function

The aim of the present study is to determine the effect of non-nutritive sweeteners on intestinal barrier function and inflammatory markers in healthy subjects in comparison to mono- and disaccharides.

  • 0 views
  • 19 Mar, 2021
  • 1 location
Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study (TIGRIS)

Prospective, multicenter, randomized, open-label study of standard of care plus the PMX cartridge versus standard of care alone in patients with endotoxemic septic shock

epinephrine
platelet count
polymyxin b
dopamine
fluid resuscitation
  • 13 views
  • 07 Jul, 2022
  • 15 locations
Assessing Gut Microbiota Mediated Health Outcomes of Whole Wheat and Its Major Bioactive Components

This study will investigate the gut microbiota-mediated effects of whole wheat consumption on human health in adults with pre-diabetes. Participants will complete two phases of intervention in random order in which they will consume either whole wheat bread (4 servings) or white bread a day for two weeks prior to …

microbiota
diabetes
fasting blood glucose
fasting
  • 0 views
  • 11 May, 2022
  • 1 location
  • 0 views
  • 17 Jun, 2022
  • 1 location
Clinical Trial to Investigate the Efficacy and Safety of LN-OS-22 on Oxidative Stress and Systemic Inflammation in Overweight and Obese Population.

peroxidation and DNA damage will be assessed by serum level of MDA before and after 2 months of extract administration. Further, metabolic endotoxemia will be assessed by the change in the plasma level of

Accepts healthy volunteers
  • 0 views
  • 14 Jul, 2022
  • 2 locations