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Found 40 clinical trials
Clinical Study to Compare the Efficacy and Safety of Macitentan and Tadalafil Monotherapies With the Corresponding Fixed-dose Combination Therapy in Subjects With Pulmonary Arterial Hypertension (PAH)

Combination therapy in pulmonary arterial hypertension (PAH) has been the subject of active investigation for more than a decade, with the benefit of targeting different pathways known to be involved in the pathogenesis of the disease. Adherence to prescribed therapy has an impact on clinical outcomes. Reducing the pill/tablet count …

  • 118 views
  • 17 Sep, 2021
  • 222 locations
Platelet Gel in Systemic Sclerosis

, infection and osteomyelitis. - Although the availability of drugs as i.v. prostacyclin analogs, oral vasodilating agents, oral phosphodiesterase-5 inhibitors, oral endothelin receptor

fibrosis
growth factor
progressive systemic sclerosis
rheumatism
endothelin
  • 24 views
  • 07 Nov, 2020
  • 1 location
Pilot Study of the Safety and Efficacy of Sulfasalazine in Pulmonary Arterial Hypertension

Under placebo control, the investigators intend to evaluate the effectiveness and safety of anti-inflammatory therapy and/or targeted drug therapy for early treatment of patients with pulmonary arterial hypertension.

digoxin
diuretics
hypertension
ambrisentan
  • 0 views
  • 24 Jan, 2021
  • 1 location
Intermitent Hypoxia and Its Pathophysiology Consequences in the Sleep Apnea-Hypopnea Syndrome.

Clinical trial on the effect of continuous positive pressure (CPAP). Objectives: 1) To assess the total or partial recovery of oxidative and inflammatory damage after recovering IH. 2) To check whether the results obtained in vitro on the recovery of the damage according to the form of manifestation of IH …

  • 0 views
  • 31 May, 2021
  • 2 locations
A Study to Evaluate Efficacy and Safety of Macitentan 75 mg in Inoperable or Persistent/Recurrent Chronic Thromboembolic Pulmonary Hypertension

The purpose of the study is to evaluate the effect of macitentan 75 mg versus placebo on exercise capacity at Week 28 in participants with chronic thromboembolic pulmonary hypertension (CTEPH).

macitentan
  • 17 views
  • 09 Sep, 2021
  • 184 locations
Vascular Dysfunction in Black Individuals: Roles of Nitric Oxide and Endothelin-1

>Specific Aim 2: To test whether a decrease in endothelin-1 signaling can increase vasodilator responses in young Black individuals.

  • 0 views
  • 07 Aug, 2021
  • 1 location
The Effect of Endothelin and L-Arginine on Racial Differences in Vasoconstriction

The goal of the study is to examine the possible mechanisms of impaired cutaneous microvascular function through local heating along with administration of vasoconstrictors.

  • 0 views
  • 26 Jan, 2021
  • 1 location
Type 1 Diabetes Endothelin and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1

The proposed study is designed to test the hypothesis that treatment of resveratrol for 12 weeks will improve both endothelin-B receptor (aim 1) and skeletal muscle mitochondrial function (aim 2

  • 0 views
  • 02 Feb, 2021
  • 1 location
A Study of Micro Dose Ambrisentan in Hospitalized Patients With Respiratory Insufficiency Due to COVID-19

oxygen. Endothelin is a potent hormone produced by human blood vessels. When increased, endothelin can result in the narrowing of blood vessels in the lung and decrease the volume of blood

  • 1 views
  • 16 Aug, 2021
  • 11 locations
Precision Medicine With Zibotentan in Microvascular Angina

Microvascular angina (MVA) is caused by abnormalities of the small vessels in the heart. Endothelin is a small chemical that circulates and accumulates in the blood vessel walls, causing them to

  • 0 views
  • 26 Jan, 2021
  • 1 location