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Found 80 clinical trials
Evaluation of Pancreatic Cystic Lesions Via EUS-guided Fine Needle Aspiration With and Without Micro Forceps Biopsies

society guidelines, PCLs with specific features should prompt additional workup with endoscopic ultrasound (EUS) for cyst characterization as well as cyst sampling. This can help determine if the cyst is

  • 0 views
  • 16 Dec, 2021
  • 1 location
PurIST Classification-Guided Adaptive Neoadjuvant Chemotherapy by RNA Expression Profiling of EUS Aspiration Samples (PANCREAS)

This is an open-label, phase II study in patients with resectable and borderline resectable pancreatic cancer.

fluorouracil
paclitaxel
cancer chemotherapy
irinotecan
leucovorin
  • 0 views
  • 11 Aug, 2022
  • 1 location
A Phase 2 Study of siG12D LODER in Combination With Chemotherapy in Patients With Locally Advanced Pancreatic Cancer (PROTACT)

In this Phase II study a dose of 2.8 mg (eight 0.35 mg siG12D-LODERs) will be administered in 12-week cycles to patients with unresectable or borderline resectable locally advanced pancreatic cancer combined with chemotherapy treatment. Primary Outcome: ORR at 6 months.

paclitaxel
cancer chemotherapy
neutrophil count
cancer
adenocarcinoma
  • 100 views
  • 01 Mar, 2022
  • 6 locations
Ultrasound-Guided Verteporfin Photodynamic Therapy for the Treatment of Unresectable Solid Pancreatic Tumors or Advanced Pancreatic Cancer, VERTPAC-02 Study

This phase II trial studies how well ultrasound-guided verteporfin photodynamic therapy works for the treatment of patients with solid pancreatic tumors that cannot be removed by surgery (unresectable) or pancreatic cancer that has spread to other places in the body (advanced). Photodynamic therapy is a type of laser device that …

endoscopic ultrasound
pancreatic neoplasm
drainage
metastatic pancreatic cancer
measurable disease
  • 24 views
  • 26 Mar, 2022
  • 1 location
Evaluating the Effect of Itraconazole on Pathologic Complete Response Rates in Esophageal Cancer

Esophageal cancer, which has a low 5-year overall survival rate for all stages (<20%) , is increasing in incidence. Previous studies have shown that the Hedgehog (Hh) and AKT signaling pathways are activated in a significant proportion of esophageal cancers. Itraconazole, a widely used anti-fungal medication, has been shown to …

esophageal cancer
chemoradiotherapy
adjuvant therapy
cancer
AKT
  • 2 views
  • 12 Feb, 2022
  • 1 location
Utility of 18FDOPA PET/MRI for Focal Hyperinsulinism

The purpose of the study is to provide access to 18F-DOPA PET to patients at Washington University and assess the utility of 18F-DOPA PET/MRI as a preoperative tool to detect and localize focal lesions in the pancreas that are causing hyperinsulinism.

  • 0 views
  • 31 Oct, 2021
  • 1 location
DNA-mutation Analysis in Cyst Fluid of Suspected Intraductal Papillary Mucinous Neoplasia of the Pancreas

Diagnostic tools are needed to identify mucinous cysts for further evaluation or follow-up respectively to identify cysts with HGD or invasive cancer at an early stage for surgical resection. Molecular genetic analysis of pancreatic cyst fluid is a new but rapidly evolving method to identify KRAS/GNAS oncogenic driver mutations in …

cyst
KRAS
pancreatic neoplasm
carcinoma
cancer
  • 0 views
  • 02 Mar, 2022
  • 1 location
Liver Transplant Combined With Neoadjuvant Chemo-radiotherapy in the Treatment of Unresectable Hilar Cholangiocarcinoma. A Prospective Multicenter Study.

A prospective multicentre pilot study which includes patients ≤ 70 years-old diagnosed of unresectable hilar cholangiocarcinoma (hCCA) ≤3cm in radial diameter, without evidence of lymph node or distant metastases. Liver transplantation preceded by neoadjuvant radio-chemotherapy will be performed in this selected group. The primary endpoint will be overall survival at …

  • 0 views
  • 05 Jul, 2022
  • 1 location
Fluorodopa F 18 in Congenital Hyperinsulinism and Insulinoma

Low blood sugars are known to cause brain damage in newborn babies. One of the most common causes of low blood sugars persisting beyond the new born period is a condition called congenital hyperinsulinism (HI). This is a disease whereby the pancreas secretes too much insulin and causes low blood …

  • 4 views
  • 23 Jan, 2021
  • 1 location
PanDox: Targeted Doxorubicin in Pancreatic Tumours (PanDox)

This study will combine focused ultrasound to generate heat, and a heat-sensitive chemotherapy drug (ThermoDox®), delivered into the blood of participants with non-resectable pancreatic cancer. We will compare this to standard delivery of chemotherapy - the drug Doxorubicin given into the blood without the addition of ultrasound. We aim to …

  • 0 views
  • 14 Mar, 2022
  • 1 location