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Found 12 clinical trials
Somatostatin Receptor Imaging in Acute Myocarditis and Cardiac Sarcoidosis

patients with 1) clinically suspected acute myocarditis (n=30-40) and 2) clinically suspected cardiac sarcoidosis (n=30-40) using clinical diagnostic criteria as well as endomyocardial biopsy as reference

  • 12 May, 2022
  • 1 location
Micophenolate Mofetil Versus Azathioprine in Myocarditis

The study is aimed at studying the direct efficacy of mycophenolate mofetil (mycophenolate mofetil, CellCept, Genentech, N015393/02, 12.08.2009) (in combination with corticosteroids (methylprednisolone, Metypred, Orion, 003467, 26.02.2016)) in the treatment of lymphocytic myocarditis: the effect on symptoms, structural and functional parameters of the heart, on the outcomes of lymphocytic myocarditis: …

left ventricular dysfunction
heart failure
angiotensin ii receptor antagonists
beta blockers
heart disease
  • 24 Mar, 2022
  • 1 location
Trifecta-Heart cfDNA-MMDX Study: Comparing the DD-cfDNA Test to MMDx Microarray Test and Central HLA Antibody Test

Demonstrate the relationship between DD-cfDNA levels and HLA antibodies in blood transplant recipient and the Molecular Microscope® (MMDx) Diagnostic System results in indication and protocol biopsies from heart transplants.

  • 25 Oct, 2022
  • 5 locations
Physiologic Assessment of Microvascular Function in Patients With Cardiac Amyloidosis

The aim of the study is to evaluate coronary flow reserve (CFR), index of microcirculatory resistance (IMR), and proportion of overt microvascular disease, defined as depressed CFR as well as elevated IMR in patients with cardiac amyloidosis. The second objective of this study is to compare results of non-invasive test …

  • 07 Oct, 2022
  • 1 location
Role of Endomyocardial Biopsy and Aetiology-based Treatment in Patients With Inflammatory Heart Disease in Arrhythmic and Non-arrhythmic Clinical Presentations: an Integrated Approach for the Optimal Diagnostic and Therapeutic Management

arrhythmic manifestations. Optimal diagnostic workflow is still to be defined. In fact, although endomyocardial biopsy (EMB) is still the diagnostic gold standard, especially for aetiology

inflammatory disorder
ventricular arrhythmia
dilated cardiomyopathy
  • 24 Jan, 2021
  • 1 location
Screening for Cardiac Amyloidosis With Nuclear Imaging for Minority Populations (SCAN-MP)

In this study, the investigators will recruit a cohort of elderly Black and Hispanic patients with heart failure to define the number of patients who have cardiac amyloidosis by utilizing highly sensitive heart imaging and blood tests. The investigators will also explore differences in genetics and sex as they relate …

  • 09 Jun, 2022
  • 4 locations
Mayo AVC Registry and Biobank

Arrhythmogenic ventricular cardiomyopathy (AVC) is a genetic condition which affects the heart and can lead to heart failure and rhythm problems, of which, sudden cardiac arrest or death is the most tragic and dangerous. Diagnosis and screening of blood-relatives is very difficult as the disease process can be subtle, but …

sudden cardiac death
dilated cardiomyopathy
Accepts healthy volunteers
exercise tests
  • 11 May, 2022
  • 2 locations
Myocardial Injury and Dysfunction Associated With COVID-19 Vaccination (MIDAVAX)

damage will be assessed with cardiac MRI and endomyocardial biopsy (EmBx) histopathology. Myocardial gene expression will be measured in RNA extracted from EmBxs mRNA abundance compared to nonfailing and

  • 10 May, 2022
  • 1 location
MRI to Predict Rejection and Failure in Transplant and Cardiomyopathy Patients

integrated approach, we will simultaneously (1) validate imaging measures of cardiac edema and fibrosis by correlating T1 and T2 map images with endomyocardial biopsy (EMB) results in Aim 1; (2) overlay T1

right heart catheterization
heart transplantation
  • 04 Oct, 2022
  • 1 location
Cardiac Amyloidosis in HFpEF

positive 99mTc-DPD scan. Four patients with positive 99mTc-DPD scan received endomyocardial biopsy and confirmed cardiac amyloid deposition. ATTRwt could be an important cause of HFpEF and it was

  • 28 May, 2022
  • 1 location