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Found 12 clinical trials
IVIg Therapy for Patients With Idiopathic Cardiomyopathy and Endomyocardial Biopsy Proven High PVB19 Viral Load

Rationale: Parvovirus B19 (PVB19) persistence in the heart has been associated with progressive cardiac dysfunction and evolution to dilated cardiomyopathy. Objective: Whether high dose of intravenous immunoglobulin (IVIg) in addition to conventional heart failure therapy achieves virus reduction, thereby resulting in improvement of cardiac function. Study design: A interventional study …

cardiomyopathy
ejection fraction
  • 23 views
  • 07 Nov, 2020
  • 1 location
Somatostatin Receptor Imaging in Acute Myocarditis and Cardiac Sarcoidosis

patients with 1) clinically suspected acute myocarditis (n=30-40) and 2) clinically suspected cardiac sarcoidosis (n=30-40) using clinical diagnostic criteria as well as endomyocardial biopsy as reference

  • 0 views
  • 24 Jan, 2021
  • 1 location
Pulse Reduction On Beta-blocker and Ivabradine Therapy

Heart failure with reduced left ventricular ejection fraction (HFrEF) is the most common form of chronic heart failure in subjects 75 years of age. Beta-blocker therapy greatly reduces mortality and improves ventricular function in HFrEF patients, but 30-40% of patients do not show improvement in ventricular function with beta blockade. …

contrast ventriculography
sacubitril/valsartan
serum pregnancy test
mineralocorticoid
chronic heart failure
  • 1 views
  • 24 Jan, 2021
  • 2 locations
A New Biomarker for the Non-invasive Diagnosis of Rejection After Heart Transplantation

rejection against the gold-standard, the endomyocardial biopsy (EMB). 80 patients will be included, both children and adults.

  • 0 views
  • 23 Jan, 2021
  • 4 locations
Physiologic Assessment of Microvascular Function in Patients With Cardiac Amyloidosis

The aim of the study is to evaluate coronary flow reserve (CFR), index of microcirculatory resistance (IMR), and proportion of overt microvascular disease, defined as depressed CFR as well as elevated IMR in patients with cardiac amyloidosis. The second objective of this study is to compare results of non-invasive test …

amyloidosis
depressed
  • 44 views
  • 26 Jan, 2021
  • 1 location
Role of Endomyocardial Biopsy and Aetiology-based Treatment in Patients With Inflammatory Heart Disease in Arrhythmic and Non-arrhythmic Clinical Presentations: an Integrated Approach for the Optimal Diagnostic and Therapeutic Management

arrhythmic manifestations. Optimal diagnostic workflow is still to be defined. In fact, although endomyocardial biopsy (EMB) is still the diagnostic gold standard, especially for aetiology

MRI
arrhythmia
myocarditis
endomyocardial biopsy
inflammatory disorder
  • 10 views
  • 24 Jan, 2021
  • 1 location
Screening for Cardiac Amyloidosis Using Nuclear Imaging for Minority Populations

In this study, the investigators will recruit a cohort of elderly Black and Hispanic patients with heart failure to define the number of patients who have cardiac amyloidosis by utilizing highly sensitive heart imaging and blood tests. The investigators will also explore differences in genetics and sex as they relate …

  • 29 views
  • 23 Jan, 2021
  • 1 location
Mayo AVC Registry and Biobank

Arrhythmogenic ventricular cardiomyopathy (AVC) is a genetic condition which affects the heart and can lead to heart failure and rhythm problems, of which, sudden cardiac arrest or death is the most tragic and dangerous. Diagnosis and screening of blood-relatives is very difficult as the disease process can be subtle, but …

exercise tests
arrhythmia
myocarditis
fibrillation
sarcoidosis
  • 218 views
  • 06 May, 2021
  • 2 locations
MRI to Predict Rejection and Failure in Transplant and Cardiomyopathy Patients

integrated approach, we will simultaneously (1) validate imaging measures of cardiac edema and fibrosis by correlating T1 and T2 map images with endomyocardial biopsy (EMB) results in Aim 1; (2) overlay T1

radiation exposure
cardiovascular catheterization
fibrosis
heart transplantation
cardiomyopathy
  • 0 views
  • 13 Mar, 2021
  • 1 location
Cardiac Amyloidosis in HFpEF

positive 99mTc-DPD scan. Four patients with positive 99mTc-DPD scan received endomyocardial biopsy and confirmed cardiac amyloid deposition. ATTRwt could be an important cause of HFpEF and it was

  • 0 views
  • 26 Jan, 2021
  • 1 location