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Found 12 clinical trials
MAintenance Therapy With Aromatase Inhibitor in Epithelial Ovarian Cancer (MATAO) (MATAO)

The purpose of this study is to evaluate the efficacy of addition of letrozole to the standard maintenance therapy in subjects following a primary diagnosis of Estrogen-receptor (ER) positive high and low grade epithelial ovarian cancer (including fallopian tube and primary peritoneal cancer) and subsequent primary treatment surgery and chemotherapy. …

cancer of the ovary
platinum-based chemotherapy
tumor debulking
peritoneal cancer
ovarian epithelial carcinoma
  • 13 views
  • 04 Oct, 2022
  • 25 locations
DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors

This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This trial enrolls participants for …

thyroxine
bone metastases
ACTH
immunosuppressive agents
ct scan
  • 6651 views
  • 17 Sep, 2022
  • 753 locations
Transvaginal Ultrasonography as a Screening Method for Ovarian Cancer

This is a large, prospective, single-arm cohort study of transvaginal ultrasonographic screening for ovarian cancer in intermediate to high-risk women from Kentucky. Detection of ovarian malignancy often occurs subsequent to the initial transvaginal sonography (TVS) screen therefore, it is important to offer continued screening to study participants based on our …

cancer of the ovary
breast cancer
  • 0 views
  • 27 Jul, 2021
  • 1 location
Weight Management Plus Megestrol Acetate in Early-stage Endometrioid Carcinoma

To investigate the efficacy of weight management plus megestrol acetate in obese patients with early endometrioid carcinoma(EEC)asking for fertility-sparing treatment

body mass index
carcinoma
endometrioid adenocarcinoma
uterine disease
endometrial carcinoma
  • 0 views
  • 04 Oct, 2022
  • 1 location
A Study to Evaluate the Combination of ATX-101 and Platinum-based Chemotherapy

This is a Phase 1b/2a multicenter study, which consists of two parts: Part 1: the Phase 1b part of the study will investigate the safety of the combination of ATX-101 with carboplatin/pegylated liposomal doxorubicin (ACD). ATX-101 will be administered intravenously in three escalation cohorts: 20, 30, and 45 mg/m² according …

carcinoma
platinum-based chemotherapy
peritoneal cancer
endometrioid adenocarcinoma
ovarian epithelial carcinoma
  • 0 views
  • 04 Oct, 2022
  • 5 locations
A Randomized Phase II Study Comparing Single-Agent Olaparib, Single Agent Cediranib, and the Combinations of Cediranib/Olaparib, Olaparib/Durvalumab (MEDI4736), Cediranib/Durvalumab (MEDI4736), Olaparib/AZD5363 (Capivasertib) in Women With Recurrent, Persistent or Metastatic Endometrial Cancer. A Multi-Arm Trial for Women With Recurrent or Persistent Endometrial Cancer

This phase II trial studies the effects of the combination of olaparib and durvalumab, cediranib and durvalumab, olaparib and capivasertib, and cediranib alone in treating patients with endometrial cancer that has come back (recurrent) or does not respond to treatment (refractory). Olaparib, cediranib, and capivasertib may stop the growth of …

chemotherapy regimen
ct scan
serous adenocarcinoma
uterine disease
platelet count
  • 122 views
  • 20 Sep, 2022
  • 471 locations
Study of STRO-002, an Anti-Folate Receptor Alpha (FolRα) Antibody Drug Conjugate in Ovarian & Endometrial Cancers

Phase 1 trial to study the safety, pharmacokinetics and preliminary efficacy of STRO-002 given intravenously every 3 weeks.

carcinoma
cancer
neuropathy
cancer of the ovary
platinum-based chemotherapy
  • 95 views
  • 02 Feb, 2022
  • 26 locations
Phase I Trial of Defatcinib and VS-6766. (FRAME)

This is a multi-centre, investigator-initiated, dose escalation, Phase I trial of the combination of the FAK inhibitor, Defactinib (VS-6063), and the dual RAF/MEK inhibitor, VS-6766 (RO5126766) in patients with advanced solid tumours. VS-6766 (RO5126766) is the same compound as CH5126766. There are two parts to this study, the dose escalation …

serum bilirubin level
KRAS
cancer
x-rays
lung cancer
  • 14 views
  • 27 Apr, 2022
  • 5 locations
A Study to Evaluate ELU001 in Patients With Solid Tumors That Overexpress Folate Receptor Alpha (FRα)

This study, ELU- FRα-1, is focused on adult subjects who have advanced, recurrent or refractory folate receptor alpha (FRα) overexpressing tumors considered to be topoisomerase 1 inhibitor-sensitive based on scientific literature, and, in the opinion of the Investigator, have no other meaningful life-prolonging therapy options available. ELU001 is a new …

cancer
cancer of the ovary
lung cancer
gastric cancer
ovarian cancer
  • 1 views
  • 04 Oct, 2022
  • 8 locations
Phase II Study of Tazemetostat in Solid Tumors Harboring an ARID1A Mutation

The FDA approved targeted agent tazemetostat inhibits EZH2 and induces durable tumor responses in patients with B-cell non-Hodgkin's lymphoma and epithelioid sarcomas. Responses have also been demonstrated in INI1 and SMARCA4 negative solid tumors patients. Since EZH2 plays a critical role in driving the biology of ARID1A mutated malignancies, we …

  • 0 views
  • 21 Mar, 2022
  • 1 location