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Found 272 clinical trials
A Phase 1/2a/3 Evaluation of the Safety and Efficacy of Adding AL3818 (Anlotinib, INN: Catequentinib), a Dual Receptor Tyrosine Kinase Inhibitor, to Standard Platinum-Based Chemotherapy in Subjects With Recurrent or Metastatic Endometrial, Ovarian, Fallopian, Primary Peritoneal or Cervical Carcinoma (AL3818)

This trial is a Phase 1b/2a/3 trial designed to evaluate the safety and efficacy of adding oral AL3818 (Anlotinib, INN: Catequentinib), a Dual Receptor Tyrosine Kinase Inhibitor, to standard platinum-based chemotherapy concurrently in Subjects with Recurrent or Metastatic Endometrial, Ovarian, Fallopian, Primary Peritoneal or Cervical Carcinoma.

cervical carcinoma
platinum-based chemotherapy
cancer
topotecan
renal function
  • 9 views
  • 11 Oct, 2022
  • 23 locations
Longitudinal Follow-up in Women With Endometrial Hyperplasia Without Atypia

for the 4th to 6th year a new grant support will be looked for. The long-term occurrence of endometrial cancer (up to15 years) data will be acquired from national cancer registry, which permission is

  • 0 views
  • 11 Apr, 2022
  • 1 location
Improving Care After Inherited Cancer Testing (IMPACT) Study (IMPACT)

The IMPACT Study seeks to refine and evaluate the effectiveness of interventions on improving guideline-adherent cancer risk management (CRM) and family communication (FC) of genetic test results. These interventions will be delivered to individuals with a documented pathogenic/likely pathogenic (P/LP) variant or variant of uncertain significance (VUS) in an inherited …

cancer
Accepts healthy volunteers
  • 0 views
  • 22 Oct, 2022
  • 1 location
A Phase II, Multicentre, Open-label, Master Protocol to Evaluate the Efficacy and Safety of Datopotamab Deruxtecan (Dato-DXd) as Monotherapy and in Combination With Anticancer Agents in Patients With Advanced/Metastatic Solid Tumours (TROPION-PanTumor03)

TROPION-PanTumor03 will investigate the safety, tolerability, and anti-tumour activity of Datopotamab Deruxtecan (Dato-DXd) as Monotherapy and in Combination with Anticancer Agents in Patients with Advanced/Metastatic Solid Tumours.

leucovorin
fluorouracil
capecitabine
durvalumab
cancer
  • 0 views
  • 17 Oct, 2022
  • 3 locations
GEN1046 Safety Trial in Patients With Malignant Solid Tumors

The purpose of the trial is to evaluate the safety of GEN1046 as monotherapy and in combination therapies in patients with malignant solid tumors

renal function
solid tumour
docetaxel
pembrolizumab
cancer
  • 95 views
  • 26 Mar, 2022
  • 41 locations
Phase 1 Study of CK-301 (Cosibelimab) as a Single Agent in Subjects With Advanced Cancers

CK-301 (cosibelimab) is a fully human monoclonal antibody of IgG1 subtype that directly binds to Programmed Death-Ligand 1 (PD-L1) and blocks its interactions with the Programmed Death-1 (PD-1) and B7.1 receptors. The primary objectives of this study are to assess the safety, tolerability and efficacy of CK-301 when administered intravenously …

programmed cell death 1 ligand 1
merkel cell carcinoma
metastatic melanoma
cancer
squamous cell carcinoma of the head and neck
  • 2181 views
  • 10 Mar, 2022
  • 26 locations
Fluorescence for Sentinel Lymph Node Identification in Cancer Surgery (GASVERT)

This is a single-center prospective clinical trial to evaluate non-inferiority of indocyanine green guided sentinel lymph node biopsy compared with the gold standard Technecium99 guided sentinel lymph node biopsy in patients with cancers and subjected to surgery. The diagnostic performance and the tolerance of indocyanine green (ICG) to the radio-isotope …

sentinel node
cancer surgery
cancer
sentinel lymph node biopsy
mammogram
  • 34 views
  • 27 Apr, 2022
  • 1 location
Methods for Increasing Genetic Testing Uptake in Michigan (MiGHT)

The primary purpose of this study is to compare three interventions, two experimental and one standard of care (usual care), to see if the experimental interventions will increase the likelihood of a participant obtaining guideline-concordant genetic testing. Eligible participants will be randomized (assigned) to one of the following interventions: 1) …

triple negative breast cancer
breast cancer
cancer
ovarian cancer
cancer of the ovary
  • 0 views
  • 16 Jun, 2022
  • 1 location
Adapting Multiple Behavior Interventions That Effectively Improve Cancer Survivor Health Cancer Survivor Health (AMPLIFY)

This research study will test the efficacy of interactive, web-based interventions that improve diet, physical activity and weight management changes among early stage survivors of breast, prostate, colorectal, endometrial, renal, thyroid, and ovarian cancers, as well as multiple myeloma and non-Hodgkin Lymphoma. Overarching outcomes also include physical function and performance, …

carcinoma in situ
body mass index
chemotherapy regimen
carcinoma
multiple myeloma
  • 68 views
  • 12 Mar, 2022
  • 2 locations
A Phase 1 Study of SGN-STNV in Advanced Solid Tumors

This trial will look at a drug called SGN-STNV to find out whether it is safe for patients with solid tumors. It will study SGN-STNV to find out what its side effects are. A side effect is anything the drug does besides treating cancer. It will also study how well …

erbb2
cancer
lung carcinoma
cancer of the ovary
human chorionic gonadotropin
  • 0 views
  • 28 Oct, 2022
  • 18 locations