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Found 21 clinical trials
Testing the Addition of the Immunotherapy Drug Pembrolizumab to the Usual Radiation Treatment for Newly Diagnosed Early Stage High Intermediate Risk Endometrial Cancer

This phase III trial compares whether the addition of pembrolizumab to radiation therapy is more effective than radiation therapy alone in reducing the risk of cancer coming back (recurrence) in patients with newly diagnosed stage I-II endometrial cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune …

  • 1 views
  • 19 Sep, 2021
  • 146 locations
VSV-hIFNbeta-NIS With or Without Ruxolitinib Phosphate in Treating Patients With Stage IV or Recurrent Endometrial Cancer

This phase I trial studies the side effects and best dose of vesicular stomatitis virus-human interferon beta-sodium iodide symporter (VSV-hIFNbeta-NIS) with or without ruxolitinib phosphate in treating patients with stage IV endometrial cancer or endometrial cancer that has come back. The study virus, VSV-hIFNbeta-NIS, has been changed so that it …

undifferentiated carcinoma
carcinosarcoma
tumor cells
serous adenocarcinoma
measurable disease
  • 15 views
  • 05 Aug, 2021
  • 2 locations
Niraparib and Copanlisib in Treating Patients With Recurrent Endometrial Ovarian Primary Peritoneal or Fallopian Tube Cancer

This phase Ib trial studies the best dose and side effects of niraparib and copanlisib in treating patients with endometrial, ovarian, primary peritoneal, or fallopian tube cancer that has come back. Niraparib and copanlisib may stop the growth of tumor cells by blocking some of the enzymes needed for cell …

replacement therapy
pleural effusion
international normalized ratio
maintenance therapy
hysterectomy
  • 21 views
  • 24 Jan, 2021
  • 1 location
Short Course Vaginal Cuff Brachytherapy in Treating Patients With Stage I-II Endometrial Cancer

This randomized phase III trial studies short course vaginal cuff brachytherapy to see how well it works compared with standard of care vaginal cuff brachytherapy in treating patients with stage I-II endometrial cancer. Short course vaginal cuff brachytherapy, also known as internal radiation therapy, uses (over a shorter period) radioactive …

tumor cells
endometrial carcinoma
carcinosarcoma
hysterectomy
brachytherapy
  • 19 views
  • 27 Jan, 2021
  • 3 locations
A Prospective Study Comparing Three Injection Sites to Detect Sentinel Lymph Nodes in Endometrial Cancer

Uterine cancer is the most common gynecologic malignancy in developed countries. Adenocarcinoma of the endometrium is the most common histologic type of uterine cancer. Endometrial cancer is the

  • 0 views
  • 05 Feb, 2021
  • 1 location
PEN-866 in Patients With Advanced Solid Malignancies

Protocol PEN-866-001 is an open-label, multi-center, first-in-human Phase 1/2a study evaluating PEN-866 in patients with advanced solid malignancies whose disease has progressed after treatment with previous anticancer therapies.

pancreatic adenocarcinoma
cancer
immunomodulators
immunostimulants
pdac
  • 272 views
  • 23 Jul, 2021
  • 14 locations
Nab-Paclitaxel and Bevacizumab in Treating Patients With Unresectable Stage IV Melanoma or Gynecological Cancers

This phase I trial studies the side effects and best dose of nab-paclitaxel and bevacizumab in treating patients with stage IV melanoma that cannot be removed by surgery (unresectable), cancer of the cervix, endometrium, ovary, fallopian tube or peritoneal cavity. Drugs used in chemotherapy, such as nab-paclitaxel, work in different …

bevacizumab
pet/ct scan
cervical carcinoma
tumor cells
cancer
  • 7 views
  • 08 Sep, 2021
  • 4 locations
A Study to Evaluate ELU001 in Patients With Solid Tumors That Overexpress Folate Receptor Alpha (FR )

This study, ELU- FR-1, is focused on adult subjects who have advanced, recurrent or refractory folate receptor alpha (FR) overexpressing tumors considered to be topoisomerase 1 inhibitor-sensitive based on scientific literature, and, in the opinion of the Investigator, have no other meaningful life-prolonging therapy options available. ELU001 is a new …

gastric cancer
breast cancer
cancer
folic acid
ovarian cancer
  • 0 views
  • 15 Sep, 2021
Evaluation of Mirvetuximab Soravtansine (IMGN853) in Women With Folate Receptor- Positive Endometrial Cancer

The purpose of this study is to evaluate the activity and safety profile of mirvetuximab soravtansine (IMGN853) in patients with type II endometrial cancers that overexpress folate receptor alpha (FR).

mirvetuximab soravtansine
adenocarcinoma
carcinosarcoma
cancer
folic acid
  • 0 views
  • 16 Aug, 2021
  • 1 location
The Role of Functional MRI and Doppler Sonography in Assessing Blood Vessel Formation Within the Tumors of Endometrial Cancer Patients

Adenocarcinoma of the endometrium is the fourth most frequent cancer in women. Surgery is the treatment of choice in patients with noninvasive or locally advanced disease. The surgical

adenocarcinoma
lymphadenectomy
metastasis
cancer
vegf
  • 10 views
  • 07 Nov, 2020
  • 1 location