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Found 16 clinical trials
Modality of Adjuvant Radiotherapy and Chemotherapy for Stage Endometrial Cancer

to determine the better modality of radiochemotherapy in stage III endometrial adenocarcinoma.

platelet count
cancer
endometrial carcinoma
carcinoma
neutrophil count
  • 0 views
  • 24 Jan, 2021
  • 1 location
Testing the Addition of the Immunotherapy Drug Pembrolizumab to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) in Stage III-IV or Recurrent Endometrial Cancer

This phase III trial studies how well the combination of pembrolizumab, paclitaxel and carboplatin works compared with paclitaxel and carboplatin alone in treating patients with endometrial cancer that is stage III or IV, or has come back (recurrent). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune …

monoclonal antibodies
replacement therapy
papillary serous adenocarcinoma
serous adenocarcinoma
brachytherapy
  • 198 views
  • 21 Jul, 2022
  • 182 locations
Evaluating Cancer Response to Treatment With Abemaciclib and Fulvestrant in Women With Recurrent Endometrial Cancer

The purpose of this study is to determine the effectiveness of the combination of abemaciclib and fulvestrant in treating this type of cancer and to determine the types and severity of side effects caused by treatment with abemaciclib and fulvestrant.

thromboplastin
papillary serous adenocarcinoma
alopecia
mucinous adenocarcinoma
neutrophil count
  • 17 views
  • 29 Jul, 2022
  • 7 locations
Abemaciclib and Letrozole in Treating Patients With Endometrial Cancer

This early phase I trial studies how well abemaciclib and letrozole work in treating patients with endometrial cancer and determines whether there are changes in patients' cancer cell biomarkers (a genetic feature or specific protein) for cell growth before and after treatment. Antihormone therapy with aromatase inhibitors, such as letrozole, …

  • 2 views
  • 15 Feb, 2022
  • 1 location
[SENTRY] Sentinel Lymph Node Biopsy Predictive Value in Endometrial Cancer of Low and Intermediate Risk

Lymphadenectomy performed for endometrial cancer influences the decision on adjuvant therapy. The aim of this study is to evaluate the rate of change in postoperative treatment based on the result of sentinel lymph node biopsy (SLNB).

laparoscopy
metastasis
cancer
indocyanine green
lymphadenectomy
  • 0 views
  • 27 Oct, 2021
  • 1 location
De-escalated Conformal Radiation Expedited Sequentially With Chemotherapy for Endometrial Cancer (DeCRESCEndo)

The goal of this study is to evaluate short course radiation in the post-operative female pelvis after hysterectomy in stage III-IVA endometrial adenocarcinoma patients, or any stage patients

neutrophil count
adenocarcinoma
carcinosarcoma
cancer
endometrial adenocarcinoma
  • 0 views
  • 11 Mar, 2022
  • 1 location
Testing Nivolumab With or Without Ipilimumab in Deficient Mismatch Repair System (dMMR) Recurrent Endometrial Carcinoma

This phase II trial tests whether the combination of nivolumab and ipilimumab is better than nivolumab alone to shrink tumors in patients with deficient mismatch repair system (dMMR) endometrial carcinoma that has come back after a period of time during which the cancer could not be detected (recurrent). Deoxyribonucleic acid …

  • 0 views
  • 10 Jul, 2022
  • 3 locations
Metformin With the Levonorgestrel-Releasing Intrauterine Device for the Treatment of Complex Atypical Hyperplasia (CAH) and Endometrial Cancer (EC) in Non-surgical Patients

-surgical patients with either complex atypical hyperplasia (CAH; n=15) or grade 1 endometrial adenocarcinoma (EC; n=15). Participants:Women, over the age of 18 years, with biopsy-proven CAH/EC who

adenocarcinoma
levonorgestrel
hyperplasia
cancer
endometrial adenocarcinoma
  • 195 views
  • 13 Oct, 2021
  • 2 locations
Onapristone and Anastrozole for the Treatment of Refractory Hormone Receptor Positive Endometrial Cancer

This phase II trial studies the effect of onapristone and anastrozole in treating patients with hormone receptor positive endometrial cancer that has not responded to previous treatment (refractory). Progesterone and estrogen are hormones that can cause the growth of endometrial cancer cells. Onapristone blocks the use of progesterone by the …

metastasis
serous adenocarcinoma
anticoagulant
endocrine therapy
neutrophil count
  • 5 views
  • 24 Jul, 2022
  • 2 locations
Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to the Usual Radiation Treatment for Newly Diagnosed Early Stage High Intermediate Risk Endometrial Cancer

This phase III trial compares whether the addition of pembrolizumab to radiation therapy is more effective than radiation therapy alone in reducing the risk of cancer coming back (recurrence) in patients with newly diagnosed stage I-II endometrial cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune …

  • 1 views
  • 27 Jul, 2022
  • 175 locations