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Found 41 clinical trials
Short-course Antibiotic Treatment in Gram-positive Cocci Infective Endocarditis

Background: it is well known that most serious complications of infective endocarditis (IE) appear in the so-called "critical phase" of the disease, which are the first days after diagnosis

  • 0 views
  • 18 Feb, 2021
  • 1 location
Surgical Implantation of TRAnscatheter vaLve in Native Mitral Annular Calcification (SITRAL) Study (SITRAL)

The purpose of this study is to establish the safety and feasibility of the Edwards SAPIEN 3 valve in subjects with mitral annular calcification (MAC) associated with mitral stenosis (MS) and/or mitral regurgitation who are at high-risk for mitral valve surgery or deemed inoperable due to the extent of calcification.

  • 60 views
  • 16 Feb, 2022
  • 5 locations
Accelerated Treatment of Endocarditis

Existing guidelines recommend a duration of antibiotic treatment of endocarditis of 4-6 weeks one or more types of intravenously administered antibiotics. The long hospitalization increases

  • 0 views
  • 09 Dec, 2021
  • 2 locations
Accelerated Treatment of Endocarditis (POETII)

Existing guidelines recommend a duration of antibiotic treatment of endocarditis of 4-6 weeks with one or two types of intravenously administered antibiotics. The long hospitalization increases

  • 0 views
  • 26 Feb, 2022
  • 6 locations
Switch to Oral Antibiotics in Gram-negative Bacteremia (SOAB)

oral medication directly or through a feeding tube. Exclusions criteria include allergy to all in-vitro active antimicrobials which are available in oral formulations, pregnancy, infective endocarditis

  • 77 views
  • 18 Apr, 2022
  • 7 locations
Antibiotics vs Antibiotics and Surgical ThERapy for Infective Endocarditis

Infective endocarditis (IE) is a deadly disease and the incidence is increasing. An important initial assessment of patients with IE includes whether surgical treatment is indicated; yet

  • 0 views
  • 25 Nov, 2021
  • 1 location
64Cu-DOTATATE PET-CT-skanning and Infective Endocarditis.

The investigators hypothesize that the 64Cu-DOTATATE will show uptake in the infected vegetations on the prosthetic heart valves and increase the accuracy of the right diagnosis - thus increasing the sensitivity and specificity compared to 18F-FDG PET/CT

Accepts healthy volunteers
  • 0 views
  • 07 Jul, 2022
  • 1 location
Partial Oral Antimicrobials to Treat Infective Endocarditis in People Who Inject Drugs

Infective endocarditis (IE) is a serious infection associated with significant morbidity and mortality. Recent studies demonstrated an increased risk of infective endocarditis in people who

  • 0 views
  • 17 Jun, 2021
  • 2 locations
Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus

Infective endocarditis (IE) is a serious infection with a significant burden for patients and hospitals (in France, median length of hospital stay = 43 days), partly due to the long duration of

vancomycin
blood culture
netilmicin
antibiotic therapy
discomfort
  • 20 views
  • 23 Feb, 2022
  • 33 locations
Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus

Infective endocarditis (IE) is a serious infection with a significant burden for patients and hospitals (in France, median length of hospital stay = 43 days), partly due to the long duration of

antibiotic therapy
discomfort
antibiotics
vancomycin
blood culture
  • 44 views
  • 23 Feb, 2022
  • 31 locations