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Found 44 clinical trials
Individualized Targeting and Neuromodulation of Late-Life Depression

An open-label, single-arm, clinical research study about how to make transcranial magnetic stimulation (TMS), an FDA-approved treatment, more effective for patients with late-life depression using fMRI.

  • 0 views
  • 30 Apr, 2021
  • 1 location
NRX-101 for Maintenance of Remission From Severe Bipolar Depression in Patients With Suicidal Ideation

NMDA antagonist drugs have increasingly been demonstrated to reduce symptoms of depression and suicidal ideation. NeuroRx has developed a sequential therapy consisting of IV NRX-100 (ketamine HCL) for rapid stabilization of symptoms of depression and suicidal ideation followed by oral NRX-101 (fixed dose combination of D-cycloserine and lurasidone) for maintenance …

depressive symptoms
hypnotics
electrocardiogram
suicidal
body mass index
  • 330 views
  • 26 Jan, 2021
  • 5 locations
ECT With Ketamine Anesthesia vs High Intensity Ketamine With ECT Rescue for Treatment-Resistant Depression

To determine if an high intensity ketamine with ECT rescue (HIKER) approach for treatment resistant depression will: 1) reduce patient suffering by hastening disease remission, 2) have fewer side effects, 3) reduce the need for ECT, and 4) be preferred by most patients. Half of participants will be randomized to …

anesthesia
remission
ketamine
electroconvulsive therapy
  • 814 views
  • 24 Jan, 2021
  • 1 location
Near Infrared Spectroscopy (NIRS) for Assessment of Depression

Develop a NIRSIT testing protocol that can be administered in the diagnostic setting and reliably distinguishes the symptoms and severity of depression, with the help of repeated measure (up to five visits per subject) comparison of patients being treated for Major Depressive Disorder with control, non-depressed subjects.

major depressive disorder
depression
depressed mood
  • 0 views
  • 24 Jan, 2021
  • 1 location
rTMS With and Without iCBT For the Treatment of Resistant Depression (TRD)

This is a prospective, two-arm randomized controlled trial. 100 patients diagnosed with resistant depression in psychiatric care clinic in Edmonton, Alberta, Canada will be randomized to one of two conditions: (1) enrolment in rTMS sessions alone (2) enrolment in the rTMS sessions plus iCBT. Patients in each group will complete …

antidepressants
benzodiazepines
transcranial magnetic stimulation
anticonvulsants
antipsychotics
  • 7 views
  • 26 Jan, 2021
  • 1 location
Noninvasive Brain Stimulation Training

Non-invasive cerebral stimulation techniques have shown potential in the treatment of neurological disorders such as chronic pain, Parkinson's disease, neglect, aphasia, memory, engine deficit and epilepsy In general, non-invasive cerebral stimulation techniques have been shown to be able to induce changes in cortical plasticity that may last even beyond the …

brain stimulation
neurosurgery
neurological injury
  • 116 views
  • 22 Jan, 2021
  • 1 location
French Observatory of ElectroConvulsive Therapy (ECT)

Since the 30s, ECT has been a psychiatric treatment mainly used for drug-resistant depressive illnesses. Clinical studies have shown its therapeutic efficiency compared to standard treatments also in other psychiatric illnesses. Although efficient, ECTs also induce side effects. In France, there is currently no consensus on providing the suitest medical …

psychiatric treatment
  • 0 views
  • 25 Jan, 2021
  • 2 locations
University of Iowa Interventional Psychiatry Service Patient Registry

The purpose of this study is to examine the effects of interventional/procedural therapies for treatment-resistant depression (TRD). These treatments include electroconvulsive therapy (ECT

major depressive disorder, single episode
electroconvulsive therapy
transcranial magnetic stimulation
ketamine
depressive episode
  • 0 views
  • 18 Apr, 2021
  • 1 location
The Danish Neuropsychological Study on the Adverse Effects of ECT

The main purpose of this study is to determine whether electroconvulsive therapy (ECT) causes any structural or functional brain changes and thus indicating its mechanism of action. The second

  • 0 views
  • 17 Feb, 2021
  • 1 location
Mechanism of Action of Electroconvulsive Therapy

This is an observational neuroimaging study assessing the effects of ECT on the brains of patients with unipolar and bipolar depression.

psychosis
depressive disorder
depression
electroconvulsive therapy
psychiatric treatment
  • 104 views
  • 11 Apr, 2021
  • 1 location