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Found 48 clinical trials
The Efficacy and Prediction of Deep Brain Stimulation for Treatment-resistant Depression

Several open-label trials have shown the therapeutic promise of deep brain stimulation (DBS) targeted to striatal and surrounding capsular areas in treatment-resistant depression (TRD). However, the results of placebo-controlled trials have been mixed, with one showing a large difference between active and sham DBS and another finding no difference. Main …

selective serotonin reuptake inhibitors
depressive episode
lithium
brain stimulation
major depressive disorder
  • 13 views
  • 03 Jun, 2022
  • 1 location
Transcranial Direct Current Stimulation (tDCS) Therapy in Major Depression

Noninvasive transcranial direct current stimulation (tDCS) is a low-intensity neuromodulation technique of minimal risk that has been used as an experimental procedure for reducing depressive symptoms and symptoms of other brain disorders. Though tDCS applied to prefrontal brain areas is shown to reduce symptoms in some people with major depressive …

selective serotonin reuptake inhibitors
depressive symptoms
antidepressants
major depressive disorder
norepinephrine
  • 0 views
  • 25 May, 2022
  • 1 location
ECT With Ketamine Anesthesia vs High Intensity Ketamine With ECT Rescue for Treatment-Resistant Depression

To determine if an high intensity ketamine with ECT rescue (HIKER) approach for treatment resistant depression will: 1) reduce patient suffering by hastening disease remission, 2) have fewer side effects, 3) reduce the need for ECT, and 4) be preferred by most patients. Half of participants will be randomized to …

ketamine
remission
electroconvulsive therapy
anesthesia
  • 816 views
  • 17 Aug, 2021
  • 1 location
TReAtment With Concurrent Exercise in Patients With Resistant Major Depression

The aim is to apply an exercise program to study symptomatic and physical changes, as well as to evaluate the improvement in functionality in a resistant depression unit. Sample: 20 patients with the resistant major depressive disorder who will undergo an exercise program. Before and after 12 weeks of intervention, …

  • 0 views
  • 03 Dec, 2021
  • 1 location
tDCS and Executive Function Training for Schizophrenia

Schizophrenia-spectrum disorders are the most persistent, debilitating, and economically burdensome mental illnesses worldwide. Cognitive remediation (CR) is a psychological intervention based on principles of learning and neuroplasticity to improve cognitive abilities. The investigators previously developed a novel CR intervention specifically targeting executive functions and aimed here to enhance its effect …

  • 0 views
  • 08 Jun, 2022
Noninvasive Brain Stimulation Training

Non-invasive cerebral stimulation techniques have shown potential in the treatment of neurological disorders such as chronic pain, Parkinson's disease, neglect, aphasia, memory, engine deficit and epilepsy In general, non-invasive cerebral stimulation techniques have been shown to be able to induce changes in cortical plasticity that may last even beyond the …

brain stimulation
neurosurgery
neurological injury
  • 116 views
  • 22 Jan, 2021
  • 1 location
French Observatory of ElectroConvulsive Therapy (ECT)

Since the 30s, ECT has been a psychiatric treatment mainly used for drug-resistant depressive illnesses. Clinical studies have shown its therapeutic efficiency compared to standard treatments also in other psychiatric illnesses. Although efficient, ECTs also induce side effects. In France, there is currently no consensus on providing the suitest medical …

psychiatric treatment
  • 0 views
  • 02 May, 2022
  • 2 locations
Acute Efficacy and 6 Months Follow up After Electroconvulsive Therapy

The overall aim of the current project is to assess the acute and long term outcome of ECT (both patient and clinician rated) in a non-selected patient cohort from ordinary clinical activity, and to seek out factors predicting response and remission, side effects and relapse.

  • 0 views
  • 05 Jun, 2022
  • 2 locations
University of Iowa Interventional Psychiatry Service Patient Registry

include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), racemic ketamine infusion and intranasal esketamine insufflation. The investigators will obtain various indicators, or

depressive disorder
antidepressants
depressive episode
bipolar disorder
depressed
  • 156 views
  • 06 May, 2022
  • 1 location
Prediction of the Cognitive Effects of Electroconvulsive Therapy Via Machine Learning and Neuroimaging (CoEffECT)

The study aims to use machine learning to predict the occurrence of episodic and autobiographical memory deficits as well as treatment response following a course of electroconvulsive therapy

hdrs
depressive disorder
depressive episode
memory impairment
major depressive disorder
  • 40 views
  • 06 Jun, 2022
  • 1 location