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Found 346 clinical trials
Clinical Trials of Multivalent Opioid Vaccine Components

Currently, abuse of prescription opioid analgesics and heroin is a serious problem in the U.S. Although several medications, including methadone, buprenorphine, and naltrexone, are available and effective in treating opioid use disorder (OUD), long-term relapse rates remain high. The current study is designed to examine a new approach to treating …

Accepts healthy volunteers
  • 31 views
  • 24 Jul, 2022
KETOMIGRAINE: Ketogenic Diet in Drug-resistant Chronic Migraineurs

Our protocol, named "KETOMIGRAINE", is based on the prescription of a Ketogenic Diet (KD) to twenty subjects with diagnosis of Chronic Migraine (CM), resistant to oral preventive treatments and non-responders to monoclonal antibodies targeting the CGRP pathway. The trial starts with one month of baseline during which are verified inclusion/exclusion …

  • 0 views
  • 27 Apr, 2022
  • 1 location
Study to Assess Safety and Efficacy of Engensis in Painful Diabetic Peripheral Neuropathy (REGAiN-1A)

The purpose of this study is to evaluate the efficacy and safety of intramuscular (IM) administration of Engensis on pain in participants with painful diabetic peripheral neuropathy (DPN) in the feet and lower legs, as compared to Placebo, as a second Phase 3, well controlled study, sufficient in supporting the …

hemoglobin a1c
glycosylated hemoglobin
diabetes
diabetic peripheral neuropathy
peripheral neuropathy
  • 738 views
  • 20 Jul, 2022
  • 20 locations
Importance of Blood Volume and Its Interaction With Cardiovascular Adaptations

The present project aims to investigate the interaction between training-induced blood volume expansion (plasma- and red blood cell volume responses), central as well as peripheral cardio-vascular adaptations. We will investigate cardiovascular responses through one year of training in recreationally active men and women as well as endurance athletes undertaking shorter …

Accepts healthy volunteers
  • 0 views
  • 04 Jun, 2022
  • 2 locations
Selinexor Treatment for Multiple Myeloma Patients Who Are Refractory to Lenalidomide-containing Therapy.

This is a pilot study evaluating the safety and efficacy of selinexor among multiple myeloma (MM) patients that are refractory to lenalidomide-containing regimens with or without steroids.

  • 0 views
  • 06 May, 2022
  • 1 location
CLOSE Versus High Density Mapping Guided Catheter Ablation of Paroxysmal Atrial Fibrillation

The aim of this study is to compare two methods of catheter ablation for treatment of paroxysmal atrial fibrillation (AF). The first method being a modified CLOSE protocol used for the control group and the second high density mapping guided isolation of pulmonary veins used for the interventional group. Comparison …

  • 0 views
  • 09 Mar, 2021
  • 1 location
Adjuvant CAPECITABINE in High Risk PSEUDOMYXOMA PERITONEI Patients (ACAPP)

This is a phase II, mono institutional, non comparative study, evaluating adjuvant capecitabine in patients affected by KRAS mutated Pseudomyxoma peritonei treated with cytoreductive surgery and HIPEC. Patient will be treated with 8 cycles of the study regimen that include: Capecitabine 1250 mg/m2 PO BID day 1-14 q21 days

  • 0 views
  • 27 Apr, 2022
  • 1 location
Pain Management After Total Knee Replacement

Aim of this study is to compare post-operative analgesic efficacy of continuous epidural analgesia versus ultrasound guided continuous femoral nerve block and adductor nerve block after unilateral total knee replacement using 0.125% bupivacaine.

  • 0 views
  • 20 Jul, 2022
  • 1 location
Radiofrequency Perineural Injection Idiopathic Carpal Tunnel Syndrome

Aim of the study The aim of the study is to evaluate the role of pulsed radiofrequency versus platelet rich plasma injection in treatment of idiopathic mild to moderate carpal tunnel syndrome Patients will be classified into three equal groups using randomized closed envelop method into three groups. Control Group …

paresthesia
Accepts healthy volunteers
bupivacaine
nerve conduction
conservative management
  • 1 views
  • 06 Oct, 2021
  • 1 location
Effect of DIRECT Transfer to ANGIOsuite on Functional Outcome in Severe Acute Stroke (DIRECTANGIO)

Rationale: Acute large-vessel strokes, requiring endovascular treatment, are currently being managed through radiology department before being transferred to the angiography room. However, patients with severe neurological deficit have demonstrated even greater benefits from recanalization as the symptom onset-to-reperfusion time is shortened to less than 1 hour. Recent pilot study have …

  • 0 views
  • 26 Mar, 2022