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Found 375 clinical trials
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Obstructive Sleep Apnea Endotypes and Impact on Phenotypes of People Living With HIV

The investigators seek to understand how the different underlying causes of OSA affect the way people living with HIV (PLWH) experience OSA. The investigators also want to understand how symptoms of obstructive sleep apnea improve with treatment, and if this too, is affected by the underlying cause of OSA in …

HIV Vaccine
  • 41 views
  • 26 Jan, 2021
  • 1 location
None
Change in Brain Perfusion During Induction of General Anesthesia

Arterial hypotension during general anesthesia remains a factor of poor outcomes, increases the risk of myocardial infarction, acute kidney injury and 1-year mortality. Furthermore, arterial hypotension may also decrease cerebral perfusion contributing to worsen neurological outcome. It seems necessary to monitor cerebral perfusion during anesthesia and to define individual dynamic …

  • 0 views
  • 07 Mar, 2021
  • 1 location
None
Individualized Diagnosis of Endocarditis and Its Therapy With a Focus on Infected Prosthetic materiAL

Infective endocarditis (IE) is a frequent and serious complication of implanted intracardiac prosthetic material, with a high morbidity and mortality. Therefore, this study aims to improve outcome of IE, with a focus on patients with intracardiac prosthetic material. In this study the investigators deal with research questions about both the …

  • 9 views
  • 24 Jan, 2021
  • 1 location
None
Ablation of Unresectable Locally Advanced Pancreatic Cancer With Irreversible Electroporation (IRE) System

Patients with pancreatic ductal adenocarcinoma will be screened by pancreatic protocol cross-sectional imaging to see if they have locally advanced unresectable pancreatic ductal adenocarcinoma. Patients with unresectable disease will undergo at least four cycles of standard of care chemotherapy before being re-evaluated for treatment with irreversibe electroporation (i.e., Nanoknife). If …

pancreatic neoplasm
metastasis
biliary obstruction
probe
tumor markers
  • 14 views
  • 24 Feb, 2021
  • 1 location
None
Pacing to Maintain Physiologic Ventricular Activation

Right ventricular pacing causes ventricular dyssynchrony and may be associated with impaired outcome. In the last decade, several approaches for more physiological pacing became available and were implemented in the latest guidelines. However, compared to conventional device implantation, cardiac resynchronization, His bundle pacing and left bundle area pacing remain demanding …

cardiac resynchronization therapy
  • 2 views
  • 24 Jan, 2021
  • 1 location
None
MRI to Predict Rejection and Failure in Transplant and Cardiomyopathy Patients

Overall Research Strategy of this protocol is to refine and validate noninvasive CMR imaging sequences with invasive hemodynamic and pathology results to create a comprehensive, noninvasive, radiation-reduced regimen for pediatric cardiomyopathy and cardiac transplant assessment. We were the first to perform MR-guided cardiac catheterization in US children, and have accumulated …

fibrosis
right heart catheterization
MRI
radiation exposure
heart transplantation
  • 0 views
  • 13 Mar, 2021
  • 1 location
None
Diastolic dYsfunctioN AssessMent in critICally Ill Patients

The role of the left ventricular diastolic function (LVDD) in the weaning failure from mechanical ventilation in unclear. Specifically, is unclear whether the outcome of the weaning process could be affected by a pre-existing LVDD (before ICU admission), or by the worsening of a chronic pattern, or by a de-novo …

diastolic dysfunction
  • 0 views
  • 27 Jun, 2021
  • 8 locations
None
CGRP Inhibition Autonomic Function and Migraine

The purpose of this clinical study is to better understand the function of the autonomic nervous system in patients with migraine. We aim to understand whether the autonomic functions change depending on the migraine status (i.e. whether they are between or during attacks) and whether the CGRP monoclonal antibody (mAb) …

  • 0 views
  • 26 Jan, 2021
  • 1 location
None
Pain Avoidance Behavior and Its Relation to Risk for Opioid Use in Chronic Pain Patients

This study is designed to find behavioral and neurophysiological correlates of pain avoidance behavior among chronic pain patients, controlling for risk for opioid use disorder. Further, traits and risk factors that contribute to pain avoidance behavior will be investigated. The knowledge gained will broaden the current understanding of mechanisms involved …

anxiety
opioid
chronic pain
  • 0 views
  • 30 Jan, 2021
  • 1 location
None
Non Invasive Use of Pressure-Volume Loop in the Operating Room

In patients under general anesthesia, the prevention of intraoperative hypotension to maintain blood pressure (BP) close to the initial blood pressure, i.e. before anesthesia, is essential to reduce the risk of death and improve surgical outcomes. Vasoactive agents are commonly used to correct this hypotension (Phenylephrine Ephedrine Noradrenaline). These three …

  • 0 views
  • 11 Mar, 2021
  • 1 location