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Found 359 clinical trials
MRI to Predict Rejection and Failure in Transplant and Cardiomyopathy Patients

Overall Research Strategy of this protocol is to refine and validate noninvasive CMR imaging sequences with invasive hemodynamic and pathology results to create a comprehensive, noninvasive, radiation-reduced regimen for pediatric cardiomyopathy and cardiac transplant assessment. We were the first to perform MR-guided cardiac catheterization in US children, and have accumulated …

right heart catheterization
heart transplantation
radiation exposure
  • 13 Mar, 2021
  • 1 location
Results of Coronary Artery Bypass Grafting in Obese Patients

This study is planned to assess the effect of obesity (BMI over 30 kg / m2) on hospital outcomes of isolated coronary artery bypass grafting in patients with chronic ischemic heart disease.

  • 19 Jun, 2021
  • 1 location
Change in Brain Perfusion During Induction of General Anesthesia

Arterial hypotension during general anesthesia remains a factor of poor outcomes, increases the risk of myocardial infarction, acute kidney injury and 1-year mortality. Furthermore, arterial hypotension may also decrease cerebral perfusion contributing to worsen neurological outcome. It seems necessary to monitor cerebral perfusion during anesthesia and to define individual dynamic …

  • 07 Mar, 2021
  • 1 location
Diastolic dYsfunctioN AssessMent in critICally Ill Patients

The role of the left ventricular diastolic function (LVDD) in the weaning failure from mechanical ventilation in unclear. Specifically, is unclear whether the outcome of the weaning process could be affected by a pre-existing LVDD (before ICU admission), or by the worsening of a chronic pattern, or by a de-novo …

diastolic dysfunction
  • 27 Jun, 2021
  • 8 locations
Reaching the Frail Elderly for the Management of Atrial Fibrillation

The overall objective of the project is to develop a collaboration model between the patient, the patient's General Practitioner (GP) and the cardiologist at the hospital in a seamless collaborative model dubbed the "Cardio-relay model". The specific purpose of the pilot project is to ease performing heart rhythm monitoring with …

  • 16 Jul, 2021
  • 1 location
CGRP Inhibition Autonomic Function and Migraine

The purpose of this clinical study is to better understand the function of the autonomic nervous system in patients with migraine. We aim to understand whether the autonomic functions change depending on the migraine status (i.e. whether they are between or during attacks) and whether the CGRP monoclonal antibody (mAb) …

  • 26 Jan, 2021
  • 1 location
Pain Avoidance Behavior and Its Relation to Risk for Opioid Use in Chronic Pain Patients

This study is designed to find behavioral and neurophysiological correlates of pain avoidance behavior among chronic pain patients, controlling for risk for opioid use disorder. Further, traits and risk factors that contribute to pain avoidance behavior will be investigated. The knowledge gained will broaden the current understanding of mechanisms involved …

chronic pain
  • 30 Jan, 2021
  • 1 location
Non Invasive Use of Pressure-Volume Loop in the Operating Room

In patients under general anesthesia, the prevention of intraoperative hypotension to maintain blood pressure (BP) close to the initial blood pressure, i.e. before anesthesia, is essential to reduce the risk of death and improve surgical outcomes. Vasoactive agents are commonly used to correct this hypotension (Phenylephrine Ephedrine Noradrenaline). These three …

  • 11 Mar, 2021
  • 1 location
Predictors of Adverse Left Ventricular Remodeling and Final Infarct Size After Primary Percutaneous Coronary Intervention for ST Elevation Myocardial Infarction: A Strain Analysis Study Using Echocardiography and Feature Tracking Cardiac Magnetic Resonance

ST-segment elevation myocardial infarction (STEMI) is one of the most important causes of death and disability around the world. The main goal in the management of acute myocardial infarction (AMI) is early restoration of coronary artery flow in order to preserve viable myocardium. Primary percutaneous coronary intervention (PCI) has proven …

medical therapy
reperfusion therapy
  • 04 Aug, 2021
  • 1 location