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Found 381 clinical trials
eMESH Struct. 2022-23 (eMESH)

A flexible energy metabolism matched with the contractile needs of the muscle is essential to a normal heart. Loss of metabolic flexibility and cardiac systolic efficiency coexist in Sepsis-induced Myocardial Dysfunction (SIMD), a phenomenon attributed to mitochondrial dysfunction and mishandling of energy substrates. Cardiac positron emission tomography (PET) could allow …

Accepts healthy volunteers
  • 0 views
  • 04 Oct, 2022
  • 1 location
IMPact of Donor Heart Function on Recipient Outcomes - a prospectiVE Study to Increase the Utilization of Donor HEARTs

Severe heart failure is a diagnosis with a very poor prognosis. Heart transplantation is the best treatment for terminal heart failure but this type of treatment is limited by the number of available organs. About 20-25% of possible donor hearts are not considered for transplantation because they have some form …

heart transplantation
heart failure
ejection fraction
heart transplant
  • 0 views
  • 18 May, 2022
  • 1 location
Total-body 13N-NH3 PET/CT to Study the Blood Perfusion in Whole Body

The aim of our study is to analyze and quantitate whole-body blood perfusion by total-body 13N-NH3 PET/CT(uEXPLORER), and evaluate the influence to other organs caused by the decreased EF value or aortic stenosis.

Accepts healthy volunteers
  • 0 views
  • 08 Oct, 2021
  • 1 location
Predicting the Development of Myocardial Depression in Acute Neurological Patients

The purpose of this study is to assess the levels of serum catecholamines associated with myocardial depression (MD) in patients with acute neurological injury.

  • 0 views
  • 05 Jun, 2022
  • 1 location
Right Ventricular Pressure Waveform Monitoring in Cardiac Surgery (PACEPORT)

RV dysfunction has been associated with increased mortality in the ICU and cardiac surgical patients. Thus, early identification of RV dysfunction at less severe stages will allow for earlier intervention and potentially better patient outcomes. However, so far, no studies have reported prospectively the prevalence of abnormal RV pressure waveform …

  • 0 views
  • 07 Oct, 2022
  • 1 location
Clinical Investigation of the ODOCOR II CCM™ Leads in Patients With Optimizer System Implant

The objective of the ODOCOR II CCM lead study is to evaluate the safety and useability of the ODOCOR II intra-cardiac lead specifically intended to deliver CCM as an accessory lead to the Optimizer IPG.

  • 0 views
  • 13 Oct, 2022
  • 37 locations
Evaluate Long Term Cardiovascular and Pulmonary Complications After COVID-19 With Point of Care Ultrasound

We hypothesize that recovered COVID-19 patients suffer long term cardiovascular and pulmonary complications, which can be detected by point of care ultrasound. The goal is to comprehensively delineate the long term cardiovascular and pulmonary ultrasound findings in recovered COVID-19 patients, identify risks factors for prolonged heart/lung injury, evaluate long term …

  • 0 views
  • 05 Aug, 2021
  • 1 location
Evaluating Mobile Health Tool Use for Capturing Patient-centered Outcomes Measures in HF Patients

The Food and Drug Administration (FDA) recognizes the importance of developing patient-centric endpoints that are relevant to patients beyond mortality and hospitalizations. Patients with HF have reduced function capacity and quality of life (QoL) and hence it is imperative to explore interventions that impact endpoints that directly measure how a …

heart failure
diuretics
  • 0 views
  • 04 Jun, 2022
  • 6 locations
Lifestyle Behaviours of Women Newly Diagnosed With Heart Failure

Heart Failure occurs when the heart's ability to pump blood is reduced. Heart failure can lead to symptoms of breathlessness, fatigue and ankle swelling, and result in health complications including damage to other organs (e.g. kidneys), reduced function and quality of life. Although the symptoms of heart failure are similar …

heart failure
  • 0 views
  • 03 Jul, 2022
  • 1 location
Investigating the Long-term Cardiac Sequelae of Trastuzumab Therapy

The introduction of trastuzumab for the treatment of patients with human epidermal growth factor receptor 2 (HER2) positive breast cancer has had a major impact upon cancer outcomes. However, cardiac toxicity remains a substantial concern. Conventionally, this toxicity has been considered as a transient and reversible phenomenon occurring in the …

trastuzumab
erbb2
HER2
her2/neu-positive breast cancer
  • 0 views
  • 30 Aug, 2021
  • 1 location