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Found 377 clinical trials
Mechanisms of Exercise Intolerance in Heart Failure With Preserved Ejection Fraction

The global objective of this study is to determine the mechanisms of exercise intolerance and dyspnea on exertion (DOE) in patients with HFpEF and based on this pathophysiology, test whether specific exercise training programs (whole body vs single leg) will result in improved exercise tolerance.

dyspnea
ejection fraction
heart failure with preserved ejection fraction
diastolic dysfunction
  • 0 views
  • 27 May, 2022
  • 1 location
Study of JK07 in Subjects With Heart Failure With Reduced Ejection Fraction (HFrEF)

This is a Phase 1, randomized, double-blind, placebo-controlled, single-ascending dose study to assess the safety, tolerability, immunogenicity, PK, and exploratory efficacy of JK07 in subjects 18 to 80 years of age with HFrEF ≤40%. Initially 5 cohorts are planned with the option to expand the study to a total of …

  • 11 views
  • 22 Apr, 2022
  • 7 locations
Metformin for Older Patients With Heart Failure With Preserved Ejection Fraction Pilot Study (Met-PEFpilot)

diversity, leaky gut, and systemic inflammation in patients with 80 older patients with heart failure with preserved ejection fraction (HFpEF).

  • 0 views
  • 23 Oct, 2022
  • 1 location
A Study of LY3461767 in Participants With Chronic Heart Failure With Reduced Ejection Fraction

it in participants with chronic heart failure with reduced ejection fraction (HFrEF). The study will last up to 3 months and may include 5 visits.

  • 24 views
  • 04 Oct, 2022
  • 7 locations
Safety and Tolerability Study of XXB750 in Heart Failure Participants With Reduced Ejection Fraction (HFrEF)

This is a multi-center, randomized, sponsor open-label, participant and investigator blinded, placebo-controlled, single dose study to investigate the safety and tolerability of a single subcutaneous dose of XXB750 in HFrEF.

  • 0 views
  • 04 Oct, 2022
  • 2 locations
Physiologic Accelerated Pacing as a Treatment in Patients With Heart Failure With Preserved Ejection Fraction (PACE HFpEF)

Part I: Week 0-12: Quantify the effects of lower heart rate (HR) elevation on symptoms and function in patients with heart failure with preserved ejection fraction (HFpEF). The

  • 0 views
  • 04 Oct, 2022
  • 1 location
Efficacy and Safety of Qishenyiqi Dripping Pills for Treating Chronic Heart Failure With Preserved Ejection Fraction

Main objective: To evaluate the efficacy, safety and clinical dose exploration of Qishen Yiqi dripping pills in the treatment of chronic heart failure with preserved ejection fraction.

  • 0 views
  • 24 Apr, 2022
  • 15 locations
Benefits of Ketogenic Diet in Patients With Heart Failure With Preserved Ejection Fraction: A Pilot Study

This study is being done to evaluate the effects of a low carbohydrate ketogenic diet on exercise tolerance in patients with Heart Failure with Preserved Ejection Fraction (HFpEF), also known as

body mass index
diastolic heart failure
medical therapy
  • 36 views
  • 23 Oct, 2022
  • 1 location
Multi-intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells in Heart Failure With Reduced Ejection Fraction PRIME-HFrEF Study

ejection fraction. The study was a 12 months single center, randomized, double-blind, placebo-controlled trial that included 12 weeks of treatment, and 9 months of follow-up.

  • 0 views
  • 24 Nov, 2021
  • 1 location
In-hospital Initiation of Empagliflozin for the Treatment of New-onset Acute Heart Failure Regardless of Ejection Fraction: A Pilot Study (EMPA)

randomized controlled trials to reduce the combined risk of cardiovascular death or HF hospitalization in HF patients with both reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF

  • 0 views
  • 21 Oct, 2022
  • 1 location