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Found 10 clinical trials
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Evaluation of the Effect of Custom Compression Garments on Standing Static Balance in Ehlers Danlos Syndrome

Studies have shown the existence of a proprioceptive deficit in patients with Ehlers Danlos Syndrome (EDS) (genetic pathology of connective tissue with hypermobility, multifactor joint

  • 6 views
  • 29 Nov, 2021
  • 2 locations
None
Two Point Discrimination

SPECIFIC AIMS Pain in both youth and adults is a complex, subjective and personal experience, and remains poorly understood. One particularly perplexing dimension of some forms of pain is the tendency of pain to spread outside of an affected body site to adjacent location, and then to unaffected body sites. …

back pain
fibromyalgia
chronic pain
two-point discrimination
amplified musculoskeletal pain syndrome
  • 419 views
  • 24 Jan, 2021
  • 1 location
None
Complex Aortic Aneurysm Repair Using Physician Modified Endografts and Custom Made Devices

The purpose of this study is to evaluate the safety and efficacy of custom made devices, Zenith t-Branch devices and physician modification of FDA approved off-the-shelf endovascular grafts in the treatment of patients with complex abdominal aneurysms, aortoiliac aneurysms or thoracoabdominal aneurysms who (1) have anatomy not suitable for endovascular …

  • 11 views
  • 03 Feb, 2021
  • 1 location
None
Dyspnea in Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorder

Individuals with hypermobile Ehlers-Danlos Syndrome (hEDS) and Hypermobility Spectrum Disorders (HSD) often experience dyspnea. Inspiratory Muscle Training (IMT) has been shown to improve

  • 0 views
  • 01 Dec, 2021
  • 1 location
None
Motion Analysis in Sacroiliac Joint Dysfunction

Rationale: The sacroiliac joint (SIJ) is increasingly being recognized as a potential cause of chronic low back and buttock pain. The SIJ is affected in 14-22% in patients presenting with this pain. Conservative treatment options include oral analgesic use, physical therapy, radiofrequency denervation and intraarticular steroid injections. When non-surgical treatment …

  • 0 views
  • 09 Apr, 2021
  • 1 location
None
Pathogenetic Basis of Aortopathy and Aortic Valve Disease

The main purpose of this study is to define the complex genetic and pathogenic basis of thoracic aortic aneurysm (TAA) and other forms of aortopathy and/or aortic valve disease by identifying novel disease-causing genes and by identifying important genetic modifiers for aortic and aortic valve disease severity.

aortic dissection
genetic testing
aortic diseases
stenosis
computed tomography
  • 106 views
  • 23 Jan, 2021
  • 1 location
None
Genetics of Ehlers-Danlos Syndrome

We are planning to collected blood and saliva for DNA extraction to use for genetic testing of children and adults with EDS and their relatives. Medical records from other institutions and clinical notes for visits in Dr. Holick's clinic will be reviewed to obtain the following information: previous diagnosis at …

genetic testing
  • 479 views
  • 06 May, 2021
  • 1 location
None
Autonomic Small Fiber Neuropathy and Ehlers Danlos Syndromes - Prospective Study and Registry

We examine patients with different autonomic neuropathies and Ehlers Danlos syndromes compared to healthy controls at three different points over time (baseline, after 3 months and after 1.5 years) to gain knowledge about the course of this disease and understand its pathophysiology, with a focus on Small Fiber neuropathy.

ehlers-danlos syndrome
  • 20 views
  • 23 Jan, 2021
  • 1 location
None
Implementation and Evaluation of a Stepped-Care Mental Health Treatment Program for Patients With Chronic Pain

Transitional Pain Service and the GoodHope Ehlers-Danlos Syndrome Clinic at Toronto General Hospital have adapted gold standard treatments for mental health and substance use for the unique needs of

behavior therapy
anxiety
chronic pain
acceptance and commitment therapy
opioid
  • 0 views
  • 10 Oct, 2021
  • 1 location
None
Genetic Risks for Bicuspid Aortic Valve Disease

Bicuspid Aortic Valve (BAV) is the most common congenital heart malformation in adults, but very little is known about the genetic causes or risk factors for adverse outcomes. Currently, it is estimated that most cases of aortic stenosis in patients less than 65 years old are caused by BAVs. BAV …

  • 5 views
  • 27 Jan, 2021
  • 1 location