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Found 54 clinical trials
Thoracentesis to Alleviate Cardiac Pleural Effusion

The present study will examine the comparative effectiveness of two treatment strategies currently used in the treatment of patients with systolic heart failure presenting with pleural effusion. Patients will be randomized to standard medical treatment only or medical treatment and referral to thoracentesis. Study hypothesis: A strategy of referring patients …

ejection fraction
thoracentesis
heart failure
systolic heart failure
  • 6 views
  • 06 Oct, 2021
  • 11 locations
Comparing Different Sizes of Small-bore Chest Drains in Malignant Pleural Effusion

relieve dyspnea. Small bore chest tubes are recommended as the first line therapy for draining pleural effusions. However, there is no clinical data available to inform on the size of drains for better

Accepts healthy volunteers
  • 0 views
  • 24 May, 2022
  • 1 location
History of the KSHV Inflammatory Cytokine Syndrome (KICS)

Background KSHV inflammatory cytokine syndrome (KICS) is a newly recognized disease caused by Kaposi sarcoma-associated herpesvirus (KSHV). This virus can cause cancer. People with KICS can have severe symptoms. They include fever, weight loss, and fluid in the legs or abdomen. People with KICS may also be at risk of …

herpes
doxorubicin
cancer
zidovudine
fever
  • 81 views
  • 01 Jul, 2022
  • 1 location
Cervical Video Assisted Thoracoscopic Surgery (C-VATS) (CT0030)

Although thoracic NOTES may not be ready for human trials, a new minimally invasive technique to access the pleural cavity and perform pleural, pulmonary and mediastinal procedures would be possible. Cervical Video Assisted Thoracoscopic Surgery (C-VATS) is a technique that borrows from traditional VATS procedures, from cervical mediastinoscopy, and from …

thoracic surgery
  • 10 views
  • 22 Mar, 2022
  • 1 location
Study Designed to Evaluate the Effect of CimetrA in Patients Diagnosed With COVID-19 (CimetrA)

Multi-center multinational-controlled study in Israel, Brazil, Spain, and South-Africa. 240 adult patients who suffer from moderate COVID-19 infection. Safety will be assessed through collection and analysis of adverse events, blood and urine laboratory assessments and vital signs. After Screening visit, the study drug will be administrated twice a day morning …

  • 0 views
  • 29 Jun, 2022
  • 1 location
Methotrexate in the Treatment of Advanced Knee Osteoarthritis With Effusion-synovitis

This multicentre randomized placebo-controlled clinical trial aims to evaluate whether methotrexate (MTX) has effects of relieving symptoms and reducing inflammation on advanced knee osteoarthritis (OA) with inflammatory phenotype. Participants will be randomly allocated to either MTX group or placebo group receiving MTX or placebo once a week. The primary outcomes …

cavity
knee pain
methotrexate
osteoarthritis
tenderness
  • 14 views
  • 24 Feb, 2022
  • 3 locations
AMPLE-3: IPC Plus Talc vs VATS in Management of Malignant Pleural Effusion (AMPLE-3)

The purpose of this study is to determine if an indwelling catheter is more effective than surgical pleurodosis in treating malignant pleural effusion. Who is it for? You may be eligible for this study if you are an adult who is suffering from symptomatic proven pleural malignancy or an otherwise …

treatment regimen
drainage
cancer
cavity
indwelling catheter
  • 1 views
  • 02 Mar, 2022
  • 1 location
Pericardial Effusion From Acute Myocardial Infarction: Contributing Factors and Prognosis at One Year (EPERICARDIM)

This study aims to clarify, in patients with more or less abundant pericardial effusion in the acute phase of a myocardial infarction, the correlation between the existence of this effusion during the acute phase with clinical parameters, biological, angiographic, therapeutic and with transmurality, extent, microvascular obstruction and intra myocardial hemorrhage …

MRI
infarct
heart failure
myocardial infarction
  • 0 views
  • 13 Dec, 2021
  • 1 location
Autoinflation: Alternative in the Treatment of Otitis Media With Effusion (OME)

Otitis media with effusion is a common finding affecting children and the main cause of acquired hearing loss in the pediatric age. The main objective of this work is to develop a new standardized, inexpensive and simple device and evaluate the results of autoinflation, a non-invasive treatment, in improving hearing …

otoscopy
serous otitis media
hearing loss
Accepts healthy volunteers
audiogram
  • 0 views
  • 18 Apr, 2022
Does Topical Otic Drop Use at Time of Tympanostomy Tube Surgery Improve Outcomes When no Middle Ear Effusion is Present

To determine whether the use of topical otic drops intra-operative and post-operative during tympanostomy tube placement reduces the rate of tympanostomy tube occlusion and post-operative otorrhea (ear drainage) during the initial 4-week post-operative period in subjects with no middle ear effusion (fluid behind the ear drum) present at the time …

  • 0 views
  • 04 Feb, 2021
  • 1 location