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Found 10 clinical trials
Determination of Adequate Tuberculosis Regimen in Patients Hospitalized With HIV-associated Severe Immune Suppression (DATURA)

DATURA trial is a phase III, multicenter, two-arm, open-label, randomized superiority trial to compare the efficacy and the safety of an intensified tuberculosis (TB) regimen versus standard TB treatment in HIV-infected adults and adolescents hospitalized for TB with CD4 ≤ 100 cells/μL over 48 weeks: Intensified TB treatment regimen: increased …

  • 0 views
  • 11 May, 2022
  • 1 location
ADORE: Efficacy of DORavirine in Adults Living With HIV Experiencing Virological Failure on First-line Efavirenz-based Antiretroviral Therapy With NNRTI Resistance (ADORE)

HIV-1 experiencing virological failure on first-line Efavirenz-based antiretroviral therapy with non-nucleoside reverse transcriptase inhibitor resistance

  • 0 views
  • 13 Jun, 2022
  • 1 location
HIV-1 Infected Patients Phase II Trial Dual Combination Doravirine/Raltegravir Open Label

The objective of antiretroviral therapy (ART) is the maintenance of HIV viral suppression, the optimal condition to prevent disease progression, to optimize immune restoration, to prevent the development of viral resistance and to reduce viral transmission. Antiretroviral therapy has to be maintained long life over decades in the absence of …

  • 1 views
  • 12 Feb, 2021
  • 1 location
Tuberculosis Clinical Trials Consortium Study 35

Hypotheses: Rifapentine (given as water-dispersible monolayer and/or fixed dose combination with isoniazid) dosing in HIV-infected and uninfected children 12 years of age with latent TB infection (LTBI) or with exposure to Mycobacterium tuberculosis (M. tuberculosis) will require higher mg/kg rifapentine dosing than adults to achieve adult- exposures which are correlated …

pulmonary tuberculosis
mycobacterium tuberculosis
hiv dna
rifapentine
isoniazid
  • 2 views
  • 24 Feb, 2022
  • 1 location
Efficacy and Safety of Ainuovirine Treating With AIDS Patients (ESATA)

safe and potent, it solves the problem from the first-generation NNRTIs such as Efavirenz with large side effects and the second-generation like Rilpivirine not suitable for high viral load, but there

  • 0 views
  • 01 Jul, 2022
  • 1 location
Assess Therapeutic Efficacy and Emergence of HIV Drug Resistance Following Initiation of TLD

taking anti-HIV medication that contains a nonnucleoside reverse transcriptase inhibitor (NNRTI) drug (such as Efavirenz or Nevirapine) (Group 1). People switching to TLD, after taking anti-HIV

  • 40 views
  • 10 Mar, 2022
  • 14 locations
Antiretroviral Pregnancy Registry (APR): Multi-sponsor Registry to Detect Any Major Teratogenic Effect Involving Any of the Registry Drugs When Administered to Pregnant Women. (APR)

The purpose of the Antiretroviral Pregnancy Registry (Registry) is to detect any major teratogenic effect involving any of the Registry drugs when administered to pregnant women. Registration is voluntary and confidential with information obtained from the health care provider. A Registry-assigned identifier allows for follow-up capability. Information on subjects is …

hepatitis
antiretroviral
HIV Vaccine
antiretrovirals
antiretroviral agents
  • 70 views
  • 04 May, 2022
  • 1 location
Same-Day Antiretroviral Therapy Initiation

Data from a total of 2,500 walk-in or referred individuals who have been confirmed (diagnosed) HIV positive and accessing care and treatment services at the hospitals targeted by this study will be examined. The starting period for this project is estimated to be the last quarter (Q4) of fiscal year …

antiretroviral
HIV Vaccine
antiretroviral therapy
antiretroviral agents
  • 61 views
  • 13 Feb, 2022
  • 11 locations
A Long-term Follow-up of the HIV-NAT Cohort

With HIV/AIDS increasingly considered a chronic disease, 24-, or 48-week data from antiretroviral studies are no longer sufficient. Only with long-term follow-up and outcome data will shed some much-needed light on the answers of questions that have stumped us for several years. Data from a large observational cohort of patients …

hiv viral load
antiretroviral
HIV Vaccine
antiretroviral therapy
antiretroviral agents
  • 2 views
  • 05 Apr, 2022
  • 1 location
Contributing Factors for Poor HIV Treatment Response in Children With TB/HIV Coinfection

Efavirenz (EFV)-based antiretroviral therapy (ART) remains the preferred regimen in human immunodeficiency virus (HIV)-infected children aged 3 years or older on rifampin-containing

immunodeficiency
efavirenz
antituberculous drugs
antiretroviral therapy
antiretroviral agents
  • 1 views
  • 13 Apr, 2022
  • 1 location