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Found 719 clinical trials
Respiratory Variation of Superior Vena Cava in Transthoracic View as a Fluid Responsiveness Predictor

Fluid evaluation is relevant in critical care. Cardiac ultrasound is the first line of evaluation in hemodynamic characterization of patients in shock, to tailor therapy. Fluid responsiveness predictors allow to better decide when to administer fluids, and transesophagic view of superior vena cava is an effective one. Recently a transthoracic …

  • 05 Jun, 2022
  • 1 location
Evaluation of Nidus Occlusion After Gamma Knife Radiosurgery of Cerebral Arteriovenous Malformations Using Magnetic Resonance Imaging

Cerebral arteriovenous malformations (AVMs) are abnormal vessels, connecting cerebral arteries and veins. They form a bundle which is called nidus. Rupture of an AVM leads to intracranial hemorrhage often causing neurological impairment or even death. As treatment can be associated with high rates of morbidity and mortality, AVMs still remain …

intracranial hemorrhage
gamma knife radiosurgery
  • 12 Feb, 2022
  • 1 location
Multiparametric Cardiac MRI in Patients Under CAR T-cell Therapy

Recently chimeric antigen receptor (CAR) T-cell therapy, a new class of chemo therapy, has gained regulatory approval for the treatment of diseases such as B-cell lymphoma. Known side effects include cytokine release syndrome, which has been described to lead to myocarditis, but larger studies exploring this relationship are currently lacking. …

  • 20 Jun, 2022
  • 1 location
Prediction of Aortic Dilatation and Rupture

Aortic aneurysm is a very common incidental finding in the diagnostic imaging of the chest. It is especially common in middle aged men (up to 40 %). It is called as a silent killer, since it can lead to aortic dissection and rupture without pre-existing symptoms. Mortality of rupture can …

  • 10 Oct, 2021
  • 1 location
The Influence of Urate-lowering Therapy on Sperm Quality of Male Gouty Patients A Prospective Cohort Study

Gout is a kind of crystal-associated arthropathy caused by monosodium urate deposition, which is directly related to hyperuricemia caused by purine metabolic disorder and/or decreased uric acid excretion. It belongs to the category of metabolic rheumatism. Gout can be complicated with kidney disease. The severe cases can occur joint destruction, …

Uric Acid Test
gouty tophus
type 2 diabetes
  • 23 Sep, 2021
  • 1 location
PROSAIC-19 - Prospective Longitudinal Assessment in a COVID-19 Infected Cohort (PROSAIC-19)

DESIGN Longitudinal prospective observational multicentre study. Primary objective: Understand the immune mechanisms driving COVID-19 disease in patients with a history of lung disease

Accepts healthy volunteers
blood test
pulmonary disease
  • 09 Jun, 2022
  • 1 location
Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) in Ischaemic Inflammatory and Takotsubo Cardiomyopathy (MEMORY)

Manganese is a calcium analogue which actively enters viable cells with intact calcium-handling mechanisms and its uptake is evident by an increase in MRI-detectable T1 relaxivity of tissues. Mangafodipir is a novel manganese-based magnetic resonance imaging (MRI) contrast medium with unique biophysical properties that are ideal for application to cardiac …

cardiac mri
Accepts healthy volunteers
heart failure
  • 18 Oct, 2021
  • 1 location
TyrosIne Kinase Inhibitors in Chronic Myeloid Leukemia: Efficacy and Tolerability. The TIKlet Study (TIKlet)

Rationale The pharmacokinetics of imatinib and nilotinib, two BCR/Abl tyrosine-kinase inhibitors (TKI), is variable among patients suffering from chronic myeloid leukemia (CML). Transmembrane transporters may play a pivotal role in interindividual variability in TKI disposition. Furthermore, minimum plasma concentrations (Cmin) higher than 1 mg/L could be associated with a higher …

bcr-abl protein
  • 24 Mar, 2022
Predicting Relapse of Ulcerative Colitis With Gastrointestinal Ultrasound (PRELAPSE)

Rationale Ulcerative colitis (UC) is remitting disease with a variable course. Predicting disease relapse after remission is important for the adjustment of medical treatment. Ileocolonoscopy is the best tool for doing this, but due to its invasiveness should be replaced by a method better accepted by the patient. Gastrointestinal ultrasound …

  • 03 Mar, 2022
  • 2 locations