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Found 716 clinical trials
A Study of Intravitreal ILUVIEN® Implant as Baseline Therapy in Patients With Early Diabetic Macular Edema (DME) (NEW DAY)

This is a randomized, masked, active-controlled, parallel-group, multi-center study that will assess the efficacy of ILUVIEN as a baseline therapy in the treatment of Center Involving DME (CI-DME). The study will enroll patients who are either treatment naïve or have not received any DME treatments for the preceding 12 months …

corrected visual acuity
spectral domain optical coherence tomography
  • 24 Mar, 2022
  • 38 locations
Pilot and Phase 2 Study of the Efficacy of a Treatment Protocol With Dexamethasone Implant Loading Dose in Patients With Diabetic Macular Edema (LOADEX)

Nowadays, steroids and anti-VEGF are the first line treatment for diabetic macular edema. Ozurdex is the most frequently used steroid and has label for both first and second line treatment

  • 18 Apr, 2021
  • 20 locations
Combination of Ranibizumab and Targeted Laser Photocoagulation (CoRaLaII)

Intravitreal injections of Ranibizumab will be applied in all patients according to treatment guidelines. The experimental group will receive additional targeted laser photocoagulation of the peripheral areas of capillary non-perfusion (up to 4 laser treatments within 1st year of the study). Based on the long-term observation after CoRaLa I study …

  • 24 May, 2022
  • 2 locations
Comparative Multicenter Randomized Study of Aflibercept Versus Placebo in Macular Telangiectasia Type 1 (TELeMAC)

manifestations of Coats' disease. It can be complicated by macular edema due to leakage from microvascular ectasia. When associated with visual loss, macular edema can be treated with different strategies

  • 15 Feb, 2022
  • 1 location
Dexamethasone for Cerebral Toxoplasmosis

with proper treatment and 80% without it. The fatality mainly due to the brain edema resulted from the mass effect lesion. In addition of anti toxoplasmosis given, adjunctive therapy such as steroid is

  • 15 May, 2021
  • 1 location
Adverse Radiation Effects After Gamma Knife Radio Surgery and Hyperbaric Oxygen Therapy (GKSHBO)

Evaluation of clinical improvement and the reduction of edema lesion documented by magnetic resonance imaging (MRI) in patients with cerebral radiation necrosis post gamma knife surgery (GKS) by

  • 24 Feb, 2022
  • 1 location
Inhibition of Bradykinin in COVID-19 Infection With Icatibant (ICASARS)

There is excess accumulation of bradykinin during symptomatic SARS CoV-2 lung infection. Bradykinin causes oedema in the lung, with reduced oxygen. It also causes vasodilation, hypotension and

  • 19 Jun, 2022
Study of Subcutaneous Interstitial Pressure During Sepsis (PISEP)

edema which is not clinically detectable below 4 litres but which becomes visible after a few days. The edema accumulates mainly at the subcutaneous level due to the high compliance of this tissue

  • 09 Feb, 2022
  • 2 locations
Osteopathic Consultation in the Emergency Department for Fresh Lateral Ligament Sprain

The study consists in recruiting patients with ankle sprains who visit the emergency department (ED). Each patient will be tested by an osteopath who we will measure pain, swelling and/or

  • 21 Dec, 2021
  • 1 location
Dexamethasone Implant for Retinal Detachment in Uveal Melanoma

with UM. Ozurdex has been approved by the Food and Drug Administration (FDA) to treat certain ocular conditions such as macular edema, non-infectious uveitis, and diabetic macular edema but it is not

  • 27 Feb, 2022