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Found 719 clinical trials
Medico Economic Evaluation of Fluocinolone Acetonide Implant Versus Dexametheasone Implant in Resistant Diabetic Macular Oedema (EMMA)

Diabetic macular oedema (DME) is the main cause of visual impairment (or visual acuity) in patients with diabetic retinopathy, as it leads to progressive thickening of the retina, which in the

  • 17 May, 2022
  • 1 location
Multiple Dose Safety and Efficacy of LKA651 in Patients With Diabetic Macular Edema

To evaluate the safety and efficacy of LKA651 in patients with macular edema from diabetic macular edema (DME),

type 2 diabetes mellitus
spectral domain optical coherence tomography
  • 04 Jul, 2022
  • 2 locations
A Study to Investigate Faricimab Treatment Response in Treatment-Naive, Underrepresented Patients With Diabetic Macular Edema (ELEVATUM)

This Phase 4 study is designed to investigate treatment response in treatment-naïve underrepresented patients with diabetic macular edema (DME) who are treated with faricimab. The study

  • 11 Jul, 2022
  • 26 locations
The Effect of Manual Lymph Drainage in the Treatment of Breast Edema

Breast conserving surgery (BCS) is widely used in the treatment of breast cancer. Breast edema can be seen frequently after BCS and radiotherapy applications. Breast edema affects quality of

  • 15 Jun, 2022
  • 1 location
Changes in Inflammatory Biomarkers Including Soluble CD14 and Hyperreflective Foci in DME Patients Treated With Aflibercept (FORESIGHT)

This study evaluates the effect of aflibercept on the change of cytokines incluing sCD14, MCP-1, IL-6, and ICAM-1 in the aqueous humor of DME patients. Additionally, changes of visual acuity (ETDRS), optical coherence tomography parameters including hyperreflective foci and thickness of macula are also investigated.

optical coherence tomography
aflibercept injection
  • 25 Jan, 2021
  • 1 location
Clinical Study of the Safety and Efficacy of BAT5906 Injection

This study is a multi-center, open, multiple-dose phase Ib/IIa clinical study evaluating the efficacy and safety of BAT5906 injection in patients with diabetic macular edema. BAT5906's phase I

  • 07 Mar, 2021
  • 18 locations
Phase III Clinical Study to Evaluate the Efficacy and Safety of PRO-169 for Diabetic Macular Edema (PRO-169)

Phase III clinical study to evaluate the efficacy, expressed as improvement in visual acuity in patients suffering diabetic macular edema after one year of treatment with PRO-169, compared to

  • 11 Mar, 2022
  • 1 location
Study to Compare Efficacy and Safety of CT-P42 in Comparison With Eylea in Patients With Diabetic Macular Edema

This is a Randomized, Active-Controlled, Double-Masked, Parallel-Group, Phase 3 Study to Compare Efficacy and Safety of CT-P42 in comparison with Eylea in Patients with Diabetic Macular Edema

  • 10 Aug, 2021
  • 1 location
A Study of Intravitreal ILUVIEN® Implant as Baseline Therapy in Patients With Early Diabetic Macular Edema (DME) (NEW DAY)

This is a randomized, masked, active-controlled, parallel-group, multi-center study that will assess the efficacy of ILUVIEN as a baseline therapy in the treatment of Center Involving DME (CI-DME). The study will enroll patients who are either treatment naïve or have not received any DME treatments for the preceding 12 months …

corrected visual acuity
spectral domain optical coherence tomography
  • 24 Mar, 2022
  • 38 locations
Pilot and Phase 2 Study of the Efficacy of a Treatment Protocol With Dexamethasone Implant Loading Dose in Patients With Diabetic Macular Edema (LOADEX)

Nowadays, steroids and anti-VEGF are the first line treatment for diabetic macular edema. Ozurdex is the most frequently used steroid and has label for both first and second line treatment

  • 18 Apr, 2021
  • 20 locations