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Found 112 clinical trials
A Randomized Trial Evaluating Personalized vs Guideline-based Well Follow-up Strategies for Patients With Early-stage Breast Cancer (REaCT-Wellness)

investigators propose a randomized trial evaluating personalized vs guideline-based well follow-up strategies for patients with early-stage breast cancer.

  • 0 views
  • 13 Oct, 2022
  • 1 location
A Phase I Dose Escalation Study of Single Fraction Pre-operative Stereotactic Partial Breast Irradiation (S-PBI) for Early Stage Breast Cancer

The purpose of this phase I trial is to evaluate dose-limiting toxicity while dose escalating single-fraction preoperative S-PBI to a presumed radioablative dose over 3 cohorts, starting with 30Gy in 1 fraction and advancing to 34Gy and 38Gy in 1 fraction.

mammogram
progesterone receptor
progesterone
estrogen
breast cancer staging
  • 55 views
  • 07 Oct, 2022
  • 1 location
NOVEMBER (Novem- (9), BrEast Radiation), A Phase II Trial of a 9 Day Course of Whole Breast Radiotherapy for Early Stage Breast Cancer (NOVEMBER)

This phase II trial studies how well hypofractionated radiation therapy works in treating patients with stage 0-IIB breast cancer. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells and have fewer side effects.

beta-human chorionic gonadotropin
invasive carcinoma
carcinoma in situ
oophorectomy
hysterectomy
  • 32 views
  • 23 Oct, 2022
  • 1 location
RAD 1802: Pilot Trial of LINAC Based Stereotactic Body Radiotherapy for Early Stage Breast Cancer Patients Eligible for Post-Operative Accelerated Partial Breast Irradiation (APBI)

This study offers single fraction radiation treatment through partial breast irradiation in patients with early stage breast cancer after having a lumpectomy.

breast-conserving surgery
invasive breast cancer
invasive carcinoma
sentinel node
carcinoma in situ
  • 0 views
  • 12 Feb, 2022
  • 1 location
12-week Exercise Intervention Program Versus Observation in Early Stage Breast Cancer Patients on the Impact on Mental Health, Quality of Life and Immune Markers

survivorship, the investigators propose to perform a phase III randomized controlled trial of a 12-week exercise intervention program versus usual care in early stage breast cancer patients, and will follow up

cancer surgery
adjuvant chemotherapy
immunostimulant
carcinoma
breast carcinoma
  • 49 views
  • 03 Mar, 2022
  • 3 locations
A Randomized Study of Oral Vitamin B12 for the Treatment of Aromatase Inhibitors (AI)-Associated Musculoskeletal Symptoms (AIMSS) in Women With Early Stage Breast Cancer

Treatment of hormone receptor (HR)-positive breast cancer with Aromatase Inhibitors (AIs) can lead to associated musculoskeletal pain and may cause patients to discontinue important treatment. This is a randomized controlled trial assessing the affect of Vitamin B12 on AI-associated joint pain and other outcomes. Participants will be randomly assigned 1:1 …

  • 0 views
  • 23 Oct, 2022
  • 1 location
Evaluating 6-months of HER2-targeted Therapy in Patients With HER2 Positive Early-stage Breast Cancer That Achieve a Pathological Complete Response to Neoadjuvant Systemic Therapy

The activity of trastuzumab in early-stage, HER2-positive breast cancer, has been demonstrated in many studies, with meta-analyses showing that in combination with a variety of chemotherapy backbones, trastuzumab reduces the risk of recurrence by nearly half, and death by a third. However, treatment with trastuzumab can result in cardiotoxicity, including …

trastuzumab
epidermal growth factor
HER2
growth factor
breast cancer staging
  • 0 views
  • 13 May, 2022
  • 1 location
Pilot Study to Evaluate the Impact of the Use of Alternative and Complementary Therapies on Therapeutic Adherence in Patients Treated With taMoxifen for Early Stage Breast Cancer (EUTACAM)

This is a pilot, prospective, interventional, monocentric study designed to evaluate, in a real-life situation, adherence to tamoxifen treatment as a function of the taking of alternative and complementary therapies in patients with localized hormone-dependent breast cancer. 200 patients will be included in the study. Each patient will be followed …

hormone therapy
breast cancer staging
tamoxifen
  • 0 views
  • 16 Oct, 2022
  • 1 location
Intratumoral TriMix Injections in Early Breast Cancer Patients (TMBA)

Patients with early breast cancer and accessible tumor lesions (1.00 to 10 ml volume) that are eligible to either surgical removal of their tumor or neoadjuvant chemotherapy will be injected with the IMP. Patients will be either treated with placebo (buffer alone, 12 patients) or with TriMix mRNA at three …

adjuvant therapy
buffer
prothrombin
cancer
breast cancer
  • 0 views
  • 07 Jun, 2022
  • 1 location
Efficacy of IORT With CT-Guided HDR Brachytherapy for Treatment of Breast Cancer

The purpose of this study is to evaluate an investigational way to provide radiation therapy to treat early-stage breast cancer at the time of surgery.

breast-conserving surgery
breast cancer staging
early-stage breast cancer
  • 0 views
  • 23 Jan, 2021
  • 3 locations