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Found 109 clinical trials
Cryoablation of Small Breast Tumors in Early Stage Breast Cancer (FROST)

This study examines the use of cryoablation as an alternative to surgery in the treatment of early stage invasive breast cancer. The hypothesis is that cryoablation will complete ablation and destroy the tumor in a selected population of women who may otherwise be adequately treated with surgery.

erbb2
breast carcinoma
endocrine therapy
carcinoma
invasive breast cancer
  • 112 views
  • 24 Jan, 2022
  • 12 locations
Weekly Single Fraction Hypofractionated Adjuvant Radiotherapy for Early Stage Breast Cancer

The current study is a prospective phase II study; Eligible patients will receive hypofractionated Irradiation at a total dose of 28.5Gy in 5 once-weekly fractions of 5.7Gy in 5 weeks to the Whole Breast or chest wall with or without peripheral lymphatic irradiation.

mastectomy
breast adenocarcinoma
breast surgery
breast cancer staging
  • 0 views
  • 25 Jan, 2021
  • 1 location
Neoadjuvant Endocrine Therapy in ER-positive, HER2-negative Early Stage Breast Cancer

The goal of this study is to access whether treatment of early state estrogen-rich breast cancers with neoadjuvant endocrine therapy will result in higher rates of margin negativity on lumpectomy specimen.

tamoxifen
erbb2
breast cancer
exemestane
estrogen
  • 0 views
  • 24 Mar, 2022
  • 1 location
Impact of Neoadjuvant Immunotherapy in Early Stage Breast Cancer Before Standard Therapy (BIS-Program)

The aim of this study is to determine, using immunohistochemistry (IHC) on biopsies and surgically removed tumor if short-treatment immunotherapy with atezolizumab monotherapy or in combination with other biologic agents (ipatasertib / Bevacizumab / Trastuzumab / Pertuzumab) is associated with increased levels of activated GzmB+ CD8+ T cells from baseline …

HER2
erbb2
estrogen
her2/neu-positive breast cancer
trastuzumab
  • 0 views
  • 14 Apr, 2022
  • 1 location
The EXCitE Study: Exercise During Chemotherapy in Older Women With Early-Stage Breast Cancer

This clinical trial evaluates the feasibility of exercise during chemotherapy in older women with stage I-III breast cancer. Previous studies have reported that exercise may reduce the chemotherapy-toxicity risk. This trial may help researchers learn if engaging in a physical activity program is feasible in patients receiving chemotherapy for breast …

  • 0 views
  • 15 Oct, 2022
  • 1 location
Phase II Protocol of Proton Therapy for Partial Breast Irradiation in Early Stage Breast Cancer

therapy will prove to be beneficial for women with early stage breast cancer. A clinical study is necessary to compare the results (good or bad) of proton radiation therapy.

HER2
erbb2
breast cancer
sentinel lymph node biopsy
ductal carcinoma
  • 27 views
  • 03 Nov, 2021
  • 8 locations
Acupuncture for Stiffness of Joint Related to Aromatase Inhibitors in Patients With Early-Stage Breast Cancer

RATIONALE: Acupuncture may help relieve joint stiffness related to aromatase inhibitors in patients with early-stage breast cancer. PURPOSE: This single arm clinical study aims to

exemestane
breast cancer staging
early-stage breast cancer
letrozole
anastrozole
  • 0 views
  • 17 Nov, 2021
  • 1 location
Avoiding Low-value Treatments in Older Women With Early-stage Breast Cancer: Piloting a Patient Decision Aid

The aim of this study is to learn whether participants find a patient guide to breast cancer treatment decisions acceptable and appropriate for use.

growth factor
erbb2
sentinel lymph node biopsy
epidermal growth factor
HER2
  • 0 views
  • 07 Oct, 2022
  • 1 location
BRE-04: Window of Opportunity Trial of Preoperative Low Dose Azacitidine in High-Risk Early Stage Breast Cancer (BRE-04)

To determine the effect of low dose azacitidine therapy on tumor infiltrating lymphocytes (TILs) in primary tumors from patients with high-risk early stage breast cancer, paired t-tests will be

  • 0 views
  • 10 May, 2022
  • 1 location
Effect of Low Intensity Vibration (LIV) on Aromatase Inhibitor- Induced Musculoskeletal Dysfunction in Early Stage Breast Cancer Survivors

measured by power generation on a stationary bicycle, among patients with early stage breast cancer planned to initiate aromatase inhibitor therapy who do not currently participate in regular exercise

tamoxifen
erbb2
aromatase inhibitor
trastuzumab
ductal carcinoma in situ
  • 15 views
  • 20 Oct, 2022
  • 1 location