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Found 112 clinical trials
Enhancing Shared Decision-Making in Breast Cancer

(delayed delivery of standard-of-care TPs) to determine impact on SDM. The intervention will be piloted in a RCT with 140 early stage breast cancer (EBC) and 140 metastatic breast cancer (MBC) patients to

  • 8 views
  • 11 May, 2022
  • 1 location
Caloric Restriction and Exercise for Protection From Anthracycline Toxic Effects (CREATE)

heart, aorta (largest artery leaving the heart), and skeletal muscle, and reduce treatment symptoms. Fifty-six early stage breast cancer patients who will receive anthracycline treatment will be

doxorubicin
breast cancer staging
anthracyclines
breast cancer
cancer
  • 143 views
  • 04 Oct, 2022
  • 1 location
SBRT in Early Breast Cancer in Elderly Women

Surgical treatment represents the standard of local therapy in patients with early breast cancer, however in women over75, the comorbidities related to aging reduce the possibility of candidates for surgical treatment. In the United Kingdom it is estimated that over 40% of elderly women do not receive surgery for their …

  • 0 views
  • 16 Oct, 2021
  • 1 location
Hypofractionated Partial Breast Irradiation in Treating Patients With Early Stage Breast Cancer

This phase II trial studies how well hypofractionated partial breast irradiation works in treating patients with early stage breast cancer. Hypofractionated radiation therapy delivers higher

ductal carcinoma in situ
estrogen
estrogen receptor
cancer
breast cancer stage
  • 122 views
  • 25 Feb, 2022
  • 12 locations
Addition of Cisplatin to Adjuvant Chemotherapy for Early Stage Breast Cancer in High-Risk Women

The investigators hypotheses that paclitaxel combined with cisplatin in a weekly-based regimen as adjuvant chemotherapy is more effective for high risk, HER2 negative breast cancer .

paclitaxel
cancer
immunohistochemistry
adjuvant chemotherapy
stage breast cancer
  • 0 views
  • 30 Sep, 2021
  • 1 location
ExclUsive endocRine Therapy Or Partial Breast Irradiation for Women Aged 70 Years Early Stage Breast Cancer

Rationale and relevance for patients and the scientific community. In low risk early stage patients 70 years, exclusive Partial Breast Irradiation (PBI) as radiation therapy (RT) approach might be superior in terms of Health-Related Quality of Life (HRQoL), when compared to exclusive endocrine therapy (ET) following breast-conserving surgery (BCS). Assuming …

  • 0 views
  • 16 Apr, 2021
  • 1 location
A Phase 3 Open-label Trial of Neoadjuvant Trastuzumab Deruxtecan (T-DXd) Monotherapy or T-DXd Followed by THP Compared to ddAC-THP in Participants With High-risk HER2-positive Early-stage Breast Cancer (DESTINY-Breast11)

This study will look at the efficacy and safety of trastuzumab deruxtecan (T-DXd) in a neoadjuvant setting, in high-risk, HER2-positive early non-metastatic breast cancer.

inflammatory breast cancer
trastuzumab
paclitaxel
pertuzumab
cyclophosphamide
  • 5 views
  • 21 Oct, 2022
  • 83 locations
Axillary Management in Breast Cancer Patients With Needle Biopsy Proven Nodal Metastases After Neoadjuvant Chemotherapy (ATNEC)

The aim of this study is to assess whether, omitting further axillary treatment (ALND and ART) for patients with early stage breast cancer and axillary nodal metastases on needle biopsy, who

axillary lymph node dissection
progesterone
estrogen
estrogen receptor
progesterone receptor
  • 839 views
  • 04 Oct, 2022
  • 49 locations
Intraoperative Radiation Therapy in Treating Patients With Breast Cancer Undergoing Breast-Conserving Surgery

patients with early stage breast cancer.

tumor cells
cancer
breast cancer staging
  • 101 views
  • 04 Oct, 2022
  • 27 locations
I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer (I-SPY)

The purpose of this study is to further advance the ability to practice personalized medicine by learning which new drug agents are most effective with which types of breast cancer tumors and by learning more about which early indicators of response (tumor analysis prior to surgery via magnetic resonance imaging …

neutrophil count
trastuzumab
cancer
carboplatin
ejection fraction
  • 87 views
  • 03 Jul, 2022
  • 26 locations