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Found 400 clinical trials
Children Affected by Rare Disease and Their Families Network

Families of children with rare diseases (i.e., not more than 5 out of 10.000 people are affected) are often highly burdened with fears, insecurities and concerns regarding the affected child and his/her siblings. The project at hand will test two innovative forms of care (CARE-FAM and WEP-CARE) at 17 sites …

  • 24 Jan, 2021
  • 30 locations
Study in Subjects With Relapsed/Refractory Follicular Lymphoma

This is a multicenter, double-blind, active-controlled, randomized, 3-stage, biomarker enrichment design featuring early futility stopping and sample-size re-estimation with safety run-in designed to evaluate the efficacy and safety of tazemetostat in combination with R2 in subjects with R/R FL, who have completed at least 1 prior systemic chemotherapy, immunotherapy, or …

  • 29 Jan, 2021
  • 54 locations
The Efficacy of Web-based Feedback After Depression Screening

The DISCOVER randomized controlled trial is designed to evaluate the effect of individual-targeted feedback after (positive) depression screening in the broader setting of the internet. A total of 1076 individuals reporting elevated levels of depression (PHQ-9 score 10) will be randomized into three groups who either receive a) an individually …

  • 01 Feb, 2021
  • 1 location
Smart Prostate Specific Antigen (PSA) Screening Study

This intervention includes the introduction of the Prostate Cancer Working Group (PCWG )Smart PSA Screening Guidelines and implementation of patient navigation/ care coordination for men with elevated PSA (>4.0 ng/mL). The guidelines include: What age to start? How often to repeat screening? What age to stop? What PSA threshold should …

  • 07 Mar, 2021
OCTA in Mild Cognitive Impairment and Alzheimer's Disease

This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography angiography (OCTA) to assess the structure and function of the retinal microvasculature in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD) or other neurodegenerative disease, multiple sclerosis, and Huntington's disease.

cognitive impairment
mild cognitive impairment
optical coherence tomography
huntington's disease
  • 26 Jan, 2021
  • 1 location
TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention

The aim of the project is to evaluate the risk-reducing salpingectomy with delayed oophorectomy as an alternative for risk-reducing salpingo-oophorectomy in high risk women with respect to ovarian cancer incidence.

fallopian tube
cancer of the ovary
  • 25 Jan, 2021
  • 2 locations
Heart Failure Events Reduction With Remote Monitoring and eHealth Support Investigator Initiated Trial

The primary objective of the study is to evaluate the efficacy of a telemedicine-based follow-up strategy compared with usual care in the management of patients with chronic heart failure (HF) at high risk of clinical events.

chronic heart failure
ejection fraction
heart failure
  • 25 Jan, 2021
  • 1 location
Screening for Occult Malignancy in Patients With Unprovoked Venous Thromboembolism

Venous thromboembolism (VTE) can be the earliest sign of cancer. Identifying occult cancers at the time of VTE diagnosis may lead to significant improvement of patients' care. This is also an upmost issue for patients who want to know if an underlying cancer might have triggered the VTE. An individual …

  • 26 Jan, 2021
  • 20 locations
A Study of Guselkumab in Participants With Active Lupus Nephritis

The purpose of this study is to evaluate the efficacy of guselkumab in participants with active lupus nephritis (LN).

antinuclear antibody
angiotensin receptor blockers
  • 25 Feb, 2021
  • 61 locations
Prevention of Obesity-related Cancers: Setting up of a Multi-Cancer Education and Prevention Program in Hong Kong

Obesity could increase the risk of many chronic diseases, including hypertension, cardiovascular diseases, high lipid level, diabetes, stroke, endometrial cancer and certain types of cancer which could benefit by secondary prevention through screening programs. The World Cancer Research Fund of the American Institute for Cancer Research has reviewed all the …

prostate specific antigen
cancer screening
weight control
chronic disease
  • 26 Jan, 2021
  • 1 location